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Pharmaceutics
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Polysaccharides-Based Delivery Systems as a Technological Tool to Target Drugs...
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Polysaccharides-Based Delivery Systems as a Technological Tool to Target Drugs to the Colon

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (10 August 2021) | Viewed by 3387

Special Issue Editors

Dr. Marlus Chorilli

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Guest Editor
Department of Drugs and Medicines, São Paulo State University—UNESP, Rodovia Araraquara Jaú, Km 1, Araraquara 14800-903, SP, Brazil
Interests: lipid-based carriers; drug delivery systems; in vivo assays; clinical assays
Special Issues, Collections and Topics in MDPI journals
Dr. Andreía Bagliotti Meneguin

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Guest Editor
Department of Drugs and Pharmaceutics, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Araraquara 14800-903, Sao Paulo, Brazil
Interests: oral drug delivery; colon-specific delivery; microencapsulation; spray-drying; film coating; pharmaceutical analysis; biopharmacy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The colon has been explored as a drug delivery site for the treatment of local and systemic pathologies. Unstable or unabsorbed drugs in the upper gastrointestinal tract (GIT), drugs used to treat colonic pathologies, and drugs for which a prolongation in absorption is necessary from a therapeutic point of view are among the drugs classes targeted to the colon. Colon-specific drug delivery systems (CSDDS) can be developed by exploiting physiological differences between the colon and the upper GIT. Given the wide variety of physicochemical properties of natural polysaccharides, specific behaviors can be achieved in colonic systems obtained from these compounds. The high reactivity of their functional groups allows a series of chemical modifications and also functionalization to increase the selectivity of drugs for the colon. This Special Issue serves to highlight the advances and challenges found in the last few years on the development of CSDDS exploiting the unique properties of natural polysaccharides.

Prof. Dr. Marlus Chorilli
Dr. Andreía Meneguin
Guest Editors

Keywords

  • colon-specific delivery systems
  • oral drug delivery
  • polysaccharides
  • tablets
  • film coating
  • microparticles
  • nanoparticles
  • oral protein delivery
  • intestinal bowel disease

Published Papers (1 paper)

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20 pages, 5215 KiB  
Article
Cellulose Nanofibers Improve the Performance of Retrograded Starch/Pectin Microparticles for Colon-Specific Delivery of 5-ASA
by Andréia Bagliotti Meneguin, Rafael Miguel Sábio, Maurício Palmeira Chaves de Souza, Richard Perosa Fernandes, Anselmo Gomes de Oliveira and Marlus Chorilli
Pharmaceutics 2021, 13(9), 1515; https://doi.org/10.3390/pharmaceutics13091515 - 19 Sep 2021
Cited by 12 | Viewed by 2812
Abstract
Cellulose nanofibers (CNF) were employed as the nanoreinforcement of a retrograded starch/pectin (RS/P) excipient to optimize its colon-specific properties. Although starch retrogradation ranged from 32 to 73%, CNF addition discretely disfavored the RS yield. This result agrees with the finding that in situ [...] Read more.
Cellulose nanofibers (CNF) were employed as the nanoreinforcement of a retrograded starch/pectin (RS/P) excipient to optimize its colon-specific properties. Although starch retrogradation ranged from 32 to 73%, CNF addition discretely disfavored the RS yield. This result agrees with the finding that in situ CNF reduces the presence of the RS crystallinity pattern. A thermal analysis revealed that the contribution of pectin improves the thermal stability of the RS/CNF mixture. Through a complete factorial design, it was possible to optimize the spray-drying conditions to obtain powders with high yield (57%) and low moisture content (1.2%). The powders observed by Field Emission Gum Scanning Electron Microscopy (FEG-SEM) had 1–10 µm and a circular shape. The developed methodology allowed us to obtain 5-aminosalicilic acid-loaded microparticles with high encapsulation efficiency (16–98%) and drug loading (1.97–26.63%). The presence of CNF in RS/P samples was responsible for decreasing the burst effect of release in simulated gastric and duodenal media, allowing the greatest mass of drug to be targeted to the colon. Considering that spray-drying is a scalable process, widely used by the pharmaceutical industry, the results obtained indicate the potential of these microparticles as raw material for obtaining other dosage forms to deliver 5-ASA to the distal parts of gastrointestinal tract, affected by inflammatory bowel disease. Full article
(This article belongs to the Special Issue Polysaccharides-Based Delivery Systems as a Technological Tool to Target Drugs to the Colon)
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