Antifungal Resistance: Current Trends and Future Strategies

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Fungal Pathogens".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 2448

Special Issue Editors


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Guest Editor
1. Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
2. Hospital Pharmacy, Azienda Ospedaliero Universitaria di Sassari, 07100 Sassari, Italy
Interests: antimicrobial resistance in nosocomial clinical microorganisms; infection; antimicrobial activity; essential oils; biofilm; biomaterials; ocular infections; orthopeadics infections
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Co-Guest Editor
Department of Biochemistry and Microbiology, Faculty of Pharmacy, Syrian Private University (SPU), Daraa International Highway, Daraa, Syria
Interests: clinical microbiology; antimicrobial resistance; sexually transmitted infections; pathogenic; virulence; bacteriology; mycology

Special Issue Information

Dear Colleagues,

For decades, fungal infections have been a difficult health condition to treat. This can be attributed to the narrow spectrum and high toxicity of clinically used antifungals, the long duration of treatment, and the high emergence of resistance towards available agents. The severity of fungal infections was brought to light during the unfortunate COVID-19 pandemic, in the form of life-threatening secondary infections in intensive care units. Candida, Cryptococcus, and Aspergillus are the most common causative organisms of life-threatening human fungal infections. Candida auris is a multidrug resistant fungus. Lomentospora prolificans has intrinsic resistance to all clinically used antifungals. Aspergillus fumigatus is becoming more resistant to treatment, making it more difficult to treat aspergillosis, with the mortality rate reaching 100% in some cases. Early diagnosis and treatment of fungal meningitis and chronic pulmonary aspergillosis can save millions of lives worldwide. Fungal infections have become a silent crisis, and immediate efforts are needed before it is too late. In this Special Issue, we will highlight current cutting-edge developments in the antifungal pipeline.

For this Special Issue, we invite you to submit original or review articles on new antifungal molecules, formulations, resistances, or studies.

Dr. Matthew Donadu
Dr. Basem Battah
Guest Editors

Manuscript Submission Information

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Keywords

  • antifungal
  • resistance
  • anti-biofilm
  • new molecules
  • molecular resistance

Published Papers (1 paper)

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Review

17 pages, 1632 KiB  
Review
Nanotechnology-Based Strategies to Combat Multidrug-Resistant Candida auris Infections
by Helal F. Hetta, Yasmin N. Ramadan, Israa M. S. Al-Kadmy, Noura H. Abd Ellah, Lama Shbibe and Basem Battah
Pathogens 2023, 12(8), 1033; https://doi.org/10.3390/pathogens12081033 - 13 Aug 2023
Cited by 2 | Viewed by 2134
Abstract
An emerging multidrug-resistant pathogenic yeast called Candida auris has a high potential to spread quickly among hospitalized patients and immunodeficient patients causing nosocomial outbreaks. It has the potential to cause pandemic outbreaks in about 45 nations with high mortality rates. Additionally, the fungus [...] Read more.
An emerging multidrug-resistant pathogenic yeast called Candida auris has a high potential to spread quickly among hospitalized patients and immunodeficient patients causing nosocomial outbreaks. It has the potential to cause pandemic outbreaks in about 45 nations with high mortality rates. Additionally, the fungus has become resistant to decontamination techniques and can survive for weeks in a hospital environment. Nanoparticles might be a good substitute to treat illnesses brought on by this newly discovered pathogen. Nanoparticles have become a trend and hot topic in recent years to combat this fatal fungus. This review gives a general insight into the epidemiology of C. auris and infection. It discusses the current conventional therapy and mechanism of resistance development. Furthermore, it focuses on nanoparticles, their different types, and up-to-date trials to evaluate the promising efficacy of nanoparticles with respect to C. auris. Full article
(This article belongs to the Special Issue Antifungal Resistance: Current Trends and Future Strategies)
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