Special Issue "The Tiny Wonders in Drug Discovery: A Small Step for Microbes, One Giant Leap for Mankind"

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Microbiology".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 176

Special Issue Editors

Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Kuala Lumpur, Malaysia
Interests: bioactive microbes; natural product; microbiome; cancer treatment; multidrug-resistant organisms
Biofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Subang Jaya, Malaysia
Interests: natural products; microbial drug discovery; molecular oncology; ethnopharmacology
Special Issues, Collections and Topics in MDPI journals
1. Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
2. Hospital Pharmacy, Azienda Ospedaliero Universitaria di Sassari, 07100 Sassari, Italy
Interests: antimicrobial resistance in nosocomial clinical microorganisms; infection; antimicrobial activity; essential oils; biofilm; biomaterials; ocular infections; orthopeadics infections
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Although tiny, microorganisms are living things that are ubiquitous in different environments and essential to supporting other life forms on Earth. The search for bioactive compounds developed from microorganisms including yeast, fungi and bacteria has yielded great success throughout human history. In fact, these “mini-factories” offer the sustainable production of bioactive compounds at a relatively cost-effective manner. Accompanied by the advancement in molecular techniques and pharmaceutical technology, researchers can now decipher the genetic codes of various microorganisms and perform genome mining to hunt for biosynthetic genes that could be exploited for the production and isolation of valuable pharmaceutical products. These innovations further hasten the drug discovery process and development of therapeutic drugs to treat various human ailments. On the same note, trillions of microbes are living inside and out of the human body, forming what researchers called the human microbiome. Apart from supporting the digestive systems of humans via the production of useful enzymes, microbes in the human body play critical role(s) in immune system development and protect the host from pathogens. A dysbiosis or imbalance in the human microbiome is associated with the development of human diseases, including metabolic diseases, cancer, allergies and so on. In the view of these aspects, researchers are also now venturing into the development of microbiome-based therapeutics via the introduction of beneficial microbes or probiotics with the aim of restoring the host to a healthy state via reverting balance and diversity in the microbiome.

This Special Issue aims to gather recent developments in the search of bioactive microbes derived from different habitats (i.e., terrestrial, ocean, mangrove forests), particularly the mechanisms by which these microbes confer beneficial effects in mankind. We especially seek manuscript submissions in original research reports and critical narrative or systematic reviews.

Dr. Hooi-Leng Ser
Dr. Bey-Hing Goh
Dr. Matthew Donadu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • beneficial microbes
  • drug discovery
  • natural product
  • microbiome

Published Papers

This special issue is now open for submission.
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