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Special Issue "Biotechnological Applications of Bacteriophages and Enteric Viruses"

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A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbial Biotechnology".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 2375

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Prof. Dr. Gislaine Fongaro

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Guest Editor

Laboratory of Applied Virology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina (UFSC), Florianópolis 88034-000, SC, Brazil
Interests: biotechnological applications of bacteriophages and enteric viruses – environmental; one health; virology

Prof. Dr. David Rodríguez-Lázaro

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Guest Editor

1. Microbiology Division, Faculty of Sciences, University of Burgos, Burgos, Spain
2. Centre for Emerging Pathogens and Global Health, University of Burgos, Burgos, Spain
Interests: food safety; food microbiology; one health; veterinary microbiology; antimicrobial resistance
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Special Issue Information

Dear Colleagues,

Studies of enteric viruses and bacteriophages have attracted interest worldwide for tge purposes of sanitary control and biotechnological uses in the face of global challenges in One Health.

This Special Issue is focused on publishing reviews and research articles on the bioprospecting of bacteriophages and enteric viruses as health biomarkers, food and environmental contaminants (water, soil, sewage, and air), and viral monitoring and microbial control based on scientifically observed phages in the topic of virology applied to One Health.

Prof. Dr. Gislaine Fongaro
Prof. Dr. David Rodríguez-Lázaro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Research

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Open AccessArticle

Molecular Characterization of Salmonella Phage Wara Isolated from River Water in Brazil

Danitza Xiomara Romero-Calle

Francisnei Pedrosa-Silva

Luiz Marcelo Ribeiro Tomé

Vagner Fonseca

Raquel Guimarães Benevides

Leila Thaise Santana de Oliveira Santos

Tulio de Oliveira

Mateus Matiuzzi da Costa

Luiz Carlos Junior Alcantara

Vasco Ariston de Carvalho Azevedo

Bertram Brenig

Thiago M. Venancio

Craig Billington

and

Aristóteles Góes-Neto

Microorganisms 2023, 11(7), 1837; https://doi.org/10.3390/microorganisms11071837 - 19 Jul 2023

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Abstract

Antimicrobial resistance is increasing despite new treatments being employed, so novel strategies are required to ensure that bacterial infections remain treatable. Bacteriophages (phages; bacteria viruses) have the potential to be used as natural antimicrobial methods to control bacterial pathogens such as Salmonella spp. A Salmonella phage, Wara, was isolated from environmental water samples at the Subaé River Basin, Salvador de Bahia, Brazil. The basin has environmental impacts in its main watercourses arising from the dumping of domestic and industrial effluents and agricultural and anthropological activities. The phage genome sequence was determined by Oxford Nanopore Technologies (ONT) MinION and Illumina HiSeq sequencing, and assembly was carried out by Racon (MinION) and Unicycler (Illumina, Illumina + MinION). The genome was annotated and compared to other Salmonella phages using various bioinformatics approaches. MinION DNA sequencing combined with Racon assembly gave the best complete genome sequence. Phylogenetic analysis revealed that Wara is a member of the Tequintavirus genus. A lack of lysogeny genes, antimicrobial resistance, and virulence genes indicated that Wara has therapeutic and biocontrol potential against Salmonella species in healthcare and agriculture. Full article

(This article belongs to the Special Issue Biotechnological Applications of Bacteriophages and Enteric Viruses)

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Open AccessArticle

Isolation and Characterization of Jumbo Coliphage vB_EcoM_Lh1B as a Promising Therapeutic Agent against Chicken Colibacillosis

Pavel Alexyuk

Andrey Bogoyavlenskiy

and

Microorganisms 2023, 11(6), 1524; https://doi.org/10.3390/microorganisms11061524 - 08 Jun 2023

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Abstract

Colibacillosis in chickens can cause the death of young stock, decrease weight gain and lead to significant economic losses. Currently, antibiotic therapy is the main method of treatment of infected animals, but unchecked use of antibiotics has led to widespread antibiotic resistance among microorganisms. Therefore, it is necessary to develop alternative methods of treating bacterial infections that are fully consistent with the One Health concept and introduce them into practice. Phage therapy meets the specified requirements perfectly. This study describes the isolation and characterization of the lytic jumbo phage vB_EcoM_Lh1B and evaluates its potential use in controlling antibiotic-resistant E. coli infection in poultry. The complete phage genome is 240,200 bp long. Open reading frame (ORF) prediction shows that the phage genome does not contain genes encoding antibiotic resistance and lysogeny factors. Based on phylogenetic and electron microscopic analysis, vB_EcoM_Lh1B belongs to the group of myoviruses of the Seoulvirus genus of the Caudoviricetes class. The bacteriophage has good resistance to a wide range of pH and temperatures and has the ability to suppress 19 out of 30 studied pathogenic E. coli strains. The biological and lytic properties of the isolated vB_EcoM_Lh1B phage make it a promising target of further study as a therapeutic agent against E. coli infections in poultry. Full article

(This article belongs to the Special Issue Biotechnological Applications of Bacteriophages and Enteric Viruses)

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Review

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Open AccessReview

Bacteriophages as Potential Clinical Immune Modulators

Estêvão Brasiliense de Souza

Aguinaldo Roberto Pinto

and

Gislaine Fongaro

Microorganisms 2023, 11(9), 2222; https://doi.org/10.3390/microorganisms11092222 - 01 Sep 2023

Viewed by 492

Abstract

Bacteriophages (phages for short) are bacteria-specific viruses that have been drawing attention when it comes to countering the ever-growing antibiotic bacterial resistance, and are being seen as one of the most promising technologies against multi-antibiotic-resistant bacteria. Although bacteriophages are commonly regarded only as anti-bacterial objects unable to directly interact with eukaryotic cell metabolism, an increasing quantity of evidence has indicated that bacteriophages can directly affect cells bacteria in both in vitro and in vivo applications, influencing the behavior of tissues and immune systems. In sight of this new range of applications, several authors have expressed enthusiasm in phage therapy as direct modulators of eukaryotic cells for clinical usage, highlighting the need for further investigations covering the pharmacology of these new “eukaryotic-viruses”, as even harmful interactions with eukaryotic cells were detected after phage therapy. The present review aims to cover and highlight mechanisms through which bacteriophages may interact with immune cells, analyzing potential clinical applications and obstacles presented in the use of bacteriophages as anti-inflammatory tools. Full article

(This article belongs to the Special Issue Biotechnological Applications of Bacteriophages and Enteric Viruses)

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