CMOS Biosensor and Bioelectronic

Dear Colleagues,

The rapid advancements in complementary metal–oxide–semiconductor (CMOS) processes have facilitated the integration of the analog sensing front end into an IC chip, making it a viable option. This cutting-edge integrated circuit boasts massive and dense sensing arrays, consisting of tens of thousands of transducers and actuators, specifically tailored for advanced biomedical applications. The notable features of high spatiotemporal-resolution (sub)cellular interfacing and molecular screening allow for label-free and non-invasive quantification of multiple live-cell biology parameters simultaneously. CMOS technology presents an array of advantageous characteristics, including consistent performance, high-volume production capabilities, ease of manufacturability, lower power consumption, enhanced integration, and reduced chip size. Consequently, it has emerged as the predominant choice for manufacturing next-generation custom microdevices. The advancement of CMOS high-density microelectrode arrays has significantly streamlined the closed-loop System-on-Chip (SoC) recording of electrical signals from larger areas and entire cell populations. In this configuration, multiple electrodes are strategically distributed across a substantial area, enabling simultaneous recording of functions from thousands of cells. This versatile capability finds utility in both in vivo implantation and in vitro cell cultures and tissue preparations, broadening its potential applications in both academic research and industrial domains.

For this Special Issue, our primary objective is to comprehensively cover the latest advances and progress in CMOS bioelectronics and its various applications. This unifying theme fosters the convergence of diverse perspectives and encourages the cross-disciplinary exchange of ideas. We anticipate a diverse array of CMOS biotechnologies contributions from various fields including:

• Actuation circuits/sensing circuits
• IC chip post-processing
• System packing
• Chemicals and bio-molecular sensing
• (sub)cellular functions mapping / extracellular recording
• Implanted biodevices
• Electrochemical biosensors
• Bio-compatible materials and interfaces
• Flexible electronics

High-quality research articles, communications, and reviews are welcome for submission.

Dr. Fuze Jiang
Prof. Dr. Ha-Duong Ngo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• actuation circuits/sensing circuits
• IC chip post-processing
• system packing
• chemicals and bio-molecular sensing
• (sub)cellular functions mapping/extracellular recording
• implanted biodevices
• electrochemical biosensors
• bio-compatible materials and interfaces
• flexible electronics