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Metals
Special Issues
Nanoparticles for Biomedical and Cosmetic Applications
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Nanoparticles for Biomedical and Cosmetic Applications

A special issue of Metals (ISSN 2075-4701). This special issue belongs to the section "Biobased and Biodegradable Metals".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 10922

Special Issue Editor

Dr. Alexander Tsouknidas

E-Mail Website
Guest Editor
Laboratory for Biomaterials and Computational Mechanics, Department of Mechanical Engineering, University of Western Macedonia, 50100 Kozani, Greece
Interests: materials; finite element modeling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanotechnology has, over the past decades, emerged as a key-enabling technology in the quest for novel diagnostics and therapeutic agents, in multiple biomedical applications. Driven by the unique characteristics of these minuscule materials that allow selective treatment at low dosages while restricting their function to the targeted anatomical site, nanoparticles have found their way from research to commercialization. As the ecosystem of bio-oriented nanotechnology continues to grow, nanomaterials have rapidly migrated from medical to cosmetic applications, with the commercialization of the latter significantly outpacing the former. Despite this, the challenges the scientific community faces are quite similar for both, questioning whether analytical methods are suitable to decode their toxicological profile and whether they account for the complex physico-chemical properties and their bio-physical interactions.

This Special Issue is intended as a platform for the publication of new developments concerning metallic nanomaterials in the field of personal/health care and welcomes the following contributions: original research, communications, methodologies, and reviews.

Dr. Alexander Tsouknidas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Synthesis and Fabrication of Nanomaterials and Scalability Thereof
  • Nanomaterials Characterization Techniques
  • Metallic Nano-Materials, -Composites and Hybrids
  • Nanostructured Surfaces
  • Bioavailability
  • Biocompatibility/Biotoxicity
  • Tissue Engineering and Nano-Enhanced Scaffolds

Published Papers (4 papers)

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Research

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15 pages, 6545 KiB  
Article
Influence of Pr3+ and CO32− Ions Coupled Substitution on Structural, Optical and Antibacterial Properties of Fluorapatite Nanopowders Obtained by Precipitation
by Dušan V. Milojkov, Miroslav Sokić, Ana Radosavljević-Mihajlović, Vojislav Dj. Stanić, Vaso Manojlović, Dragosav R. Mutavdžić and Marija Milanović
Metals 2021, 11(9), 1384; https://doi.org/10.3390/met11091384 - 31 Aug 2021
Cited by 5 | Viewed by 1581
Abstract
Coupled substitution of fluorapatite (FAP) crystal lattice plays an important role in the engineering of optically active nanomaterials. Uniform fluorapatite nanopowders doped with praseodymium (Pr3+) and carbonate (CO32−) ions have been successfully synthesized by precipitation method under room [...] Read more.
Coupled substitution of fluorapatite (FAP) crystal lattice plays an important role in the engineering of optically active nanomaterials. Uniform fluorapatite nanopowders doped with praseodymium (Pr3+) and carbonate (CO32−) ions have been successfully synthesized by precipitation method under room temperature (25 °C). The structural, morphological, chemical and optical properties of monophase material were characterized by X-ray diffraction (XRD), Fourier Transform Infrared and Far Infrared Spectroscopy (FTIR and FIR, respectively), Scanning Electron Microscopy with Energy Dispersive Spectroscopy (SEM/EDS), Transmission Electron Microscopy (TEM) and Photoluminescence Spectroscopy (PL). Coupled substitution of FAP crystal lattice with Pr3+ and CO32− reduces the crystallite size with a constant c/a ratio of 1.72. FTIR study showed that synthesized nanopowders were AB-type CO32− substitution, and FIR study revealed new Pr–O vibrations. TEM analysis was found that synthesized nanopowders were composed of irregular spheres in the nanometer range. The fluorescence of FAP nanoparticles was in the violet-blue region of the visible part of the spectrum. When Pr3+ was doped in a lattice, the violet-blue emission becomes sharper due to reabsorption. MCR–ALS analyses of fluorescence spectra indicated the shift of the maximum to the blue color with the increase in the concentration of Pr3+ ions. Additionally, luminescent nanopowders demonstrated significant antibacterial activity against Escherichia coli. As the obtained nanoparticles showed a good absorption of ultraviolet A light and reabsorption of blue-green luminescence, they are suitable for further development of optically active nanomaterials for light filtering. Optically active PrCFAP nanopowders with antibacterial properties may be promising additives for the development of multifunctional cosmetic and health care products. Full article
(This article belongs to the Special Issue Nanoparticles for Biomedical and Cosmetic Applications)
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Review

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20 pages, 5307 KiB  
Review
Review on Grain Refinement of Metallic Materials to Regulate Cellular Behavior
by Yingjian Gu, Run Huang and Yufei Hao
Metals 2022, 12(5), 829; https://doi.org/10.3390/met12050829 - 11 May 2022
Cited by 2 | Viewed by 2134
Abstract
Metallic materials have been widely used as orthopedic implants in clinics for their good mechanical, physical, and chemical properties, but their slow osseointegration rate is still one of the main issues causing implantation failure. Grain refinement has recently attracted wide attention for its [...] Read more.
Metallic materials have been widely used as orthopedic implants in clinics for their good mechanical, physical, and chemical properties, but their slow osseointegration rate is still one of the main issues causing implantation failure. Grain refinement has recently attracted wide attention for its effective improvement of cell–material interaction for biometals. In this review, the surface and bulk grain refinement mode and the influence of grain size reduction of various metallic materials including titanium, stainless steel, magnesium, zirconium, tantalum, and their alloys as well as NiTi shape memory alloys on the cell responses is summarized in detail. It is hoped that this review could help biomaterials-related researchers to understand the grain refinement of metallic materials in a timely manner, thus boosting the development of biomedical metals for clinical use. Full article
(This article belongs to the Special Issue Nanoparticles for Biomedical and Cosmetic Applications)
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22 pages, 2271 KiB  
Review
An Overview of the Production of Magnetic Core-Shell Nanoparticles and Their Biomedical Applications
by Dimitris Tsamos, Athina Krestou, Maria Papagiannaki and Stergios Maropoulos
Metals 2022, 12(4), 605; https://doi.org/10.3390/met12040605 - 31 Mar 2022
Cited by 11 | Viewed by 3412
Abstract
Several developments have recently emerged for core-shell magnetic nanomaterials, indicating that they are suitable materials for biomedical applications. Their usage in hyperthermia and drug delivery applications has escalated since the use of shell materials and has several beneficial effects for the treatment in [...] Read more.
Several developments have recently emerged for core-shell magnetic nanomaterials, indicating that they are suitable materials for biomedical applications. Their usage in hyperthermia and drug delivery applications has escalated since the use of shell materials and has several beneficial effects for the treatment in question. The shell can protect the magnetic core from oxidation and provide biocompatibility for many materials. Yet, the synthesis of the core-shell materials is a multifaceted challenge as it involves several steps and parallel processes. Although reviews on magnetic core-shell nanoparticles exist, there is a lack of literature that compares the size and shape of magnetic core-shell nanomaterials synthesized via various methods. Therefore, this review outlines the primary synthetic routes for magnetic core-shell nanoparticles, along with the recent advances in magnetic core-shell nanomaterials. As core-shell nanoparticles have been proposed among others as therapeutic nanocarriers, their potential applications in hyperthermia drug delivery are discussed. Full article
(This article belongs to the Special Issue Nanoparticles for Biomedical and Cosmetic Applications)
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15 pages, 837 KiB  
Review
A Review of the EU’s Regulatory Framework for the Production of Nano-Enhanced Cosmetics
by Theodora Karamanidou, Vasileios Bourganis, Glykeria Gatzogianni and Alexander Tsouknidas
Metals 2021, 11(3), 455; https://doi.org/10.3390/met11030455 - 10 Mar 2021
Cited by 12 | Viewed by 2830
Abstract
Literature has suggested metallic nanomaterials (NMs) for a multitude of applications in cosmetic products, either as active ingredients or excipients. Alike most high-paced industrial sectors, cosmetology continues to capitalize on its unique properties/functions (e.g., as UV-filters, colorants, etc.), adding value to a wide [...] Read more.
Literature has suggested metallic nanomaterials (NMs) for a multitude of applications in cosmetic products, either as active ingredients or excipients. Alike most high-paced industrial sectors, cosmetology continues to capitalize on its unique properties/functions (e.g., as UV-filters, colorants, etc.), adding value to a wide range of products. However, as a result of their nano-scale, NMs do not always conform with the handling guidelines of their bulk counterparts, nor do conventional analytical methods account for their complex physicochemical and biological interactions. Among others, metallic nanoparticles have attracted the interest of many over the years due to their unique features, but possible precautions should be considered because of their bio-persistent nature. As a result, it is prevalent to consider a nano-specific framework, to regulate the use of NMs and the production of nano-enhanced cosmetics. To address this, we provide insight into the NMs that are currently used in the EU market, with a focus on metallic NMs, while analyzing the underlying legislation and relevant Opinions of the Scientific Committee on Consumer Safety (SCCS), from a scientific and commercial perspective. Even though the current Cosmetics Regulation (EU Regulation No 1223/2009) already entails specific provisions on NMs, cosmetic products incorporating unauthorized NMs have been repeatedly commercialized in the European Union. Considering the potential risks of NMs if they are mishandled, we provide an analysis of the risk assessment, as stated in Article 16 of the Cosmetics Regulation, to serve as a guideline for the future growth of nano-enhanced products. Based on the limited integration of metallic NMs along with multiple non-metallic NPs into cosmetic products, the attention of the community is directed towards coordinating efforts on the integration of metallic NMs into cosmetics. Full article
(This article belongs to the Special Issue Nanoparticles for Biomedical and Cosmetic Applications)
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