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Materials for Bioengineering and Biotechnology 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 940

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Laboratory for Biomaterials and Computational Mechanics, Department of Mechanical Engineering, University of Western Macedonia, 50100 Kozani, Greece
Interests: materials; finite element modeling
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Special Issue Information

Dear Colleagues,

Biomaterials, whether of biological or synthetic origin, have evolved into an integral part of medical devices and material systems deployed for healthcare applications. Over the past two decades, biomaterials have advanced from traditional applications (orthopedic, dental, etc.) to vehicles for drug delivery, implantable biosensors, and templates to host cells and have guided their growth. The unprecedented growth of both implantable and extracorporeal material-based therapeutics was driven in part by our capacity to functionalize their surface properties along with recent advances facilitating the manipulation of matter on the nanoscale.

As a result, multifunctional biomaterials have attracted immense interest within the materials community, providing biomedical engineers, physicians, and other medical and biotechnology professionals with novel therapeutic approaches.

This new Special Issue aims to serve as a platform for peer-reviewed articles in the field of biomaterials, including but not limited to the synthesis and characterization of biomaterials, development/modification of nano-particulate systems (whether synthesized or naturally derived/isolated), applications thereof in targeted therapeutics and biomedical imaging, and interactions of biomaterial with biological systems on the cellular, tissue, and organ level. We invite original research, review articles, and communications covering one or more of the aforementioned fields. Our aim is to bring together a collection of up-to-date research and reviews from leading experts and distinguished groups within the scientific community.

Dr. Alexander Tsouknidas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • biomaterials
  • nanomaterials
  • nanocarriers
  • extracellular vesicles
  • intercellular communication
  • tissue engineering
  • scaffolds

Published Papers (1 paper)

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18 pages, 2529 KiB  
Biocompatibility of Synechococcus sp. PCC 7002 with Human Dermal Cells In Vitro
by Benedikt Fuchs, Sinan Mert, Constanze Kuhlmann, Sara Taha, Alexandra Birt, Jörg Nickelsen, Thilo Ludwig Schenck, Riccardo Enzo Giunta, Paul Severin Wiggenhauser and Nicholas Moellhoff
Int. J. Mol. Sci. 2024, 25(7), 3922; https://doi.org/10.3390/ijms25073922 - 31 Mar 2024
Viewed by 682
Being the green gold of the future, cyanobacteria have recently attracted considerable interest worldwide. This study investigates the adaptability and biocompatibility of the cyanobacterial strain Synechococcus sp. PCC 7002 with human dermal cells, focusing on its potential application in biomedical contexts. First, we [...] Read more.
Being the green gold of the future, cyanobacteria have recently attracted considerable interest worldwide. This study investigates the adaptability and biocompatibility of the cyanobacterial strain Synechococcus sp. PCC 7002 with human dermal cells, focusing on its potential application in biomedical contexts. First, we investigated the adaptability of Synechococcus PCC 7002 bacteria to human cell culture conditions. Next, we evaluated the biocompatibility of cyanobacteria with common dermal cells, like 3T3 fibroblasts and HaCaT keratinocytes. Therefore, cells were directly and indirectly cocultured with the corresponding cells, and we measured metabolic activity (AlamarBlue assay) and proliferation (cell count and PicoGreen assay). The lactate dehydrogenase (LDH) assay was performed to determine the cytotoxic effect of cyanobacteria and their nutrition medium on human dermal cells. The cyanobacteria exhibited exponential growth under conventional human cell culture conditions, with the temperature and medium composition not affecting their viability. In addition, the effect of illumination on the proliferation capacity was investigated, showing a significant impact of light exposure on bacterial growth. The measured oxygen production under hypoxic conditions demonstrated a sufficient oxygen supply for further tissue engineering approaches depending on the number of bacteria. There were no significant adverse effects on human cell viability and growth under coculture conditions, whereas the LDH assay assessed signs of cytotoxicity regarding 3T3 fibroblasts after 2 days of coculturing. These negative effects were dismissed after 4 days. The findings highlight the potential of Synechococcus sp. PCC 7002 for integration into biomedical approaches. We found no cytotoxicity of cyanobacteria on 3T3 fibroblasts and HaCaT keratinocytes, thus paving the way for further in vivo studies to assess long-term effects and systemic reactions. Full article
(This article belongs to the Special Issue Materials for Bioengineering and Biotechnology 2.0)
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