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Metabolites
Special Issues
The Link between Metabolism and Neurological Disorders
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The Link between Metabolism and Neurological Disorders

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 5066

Special Issue Editor

Dr. Lionel Carneiro

E-Mail Website
Guest Editor
Research group: Physiopathology of the gut brain axis, Digestive health research institute (IRSD), Inserm U1220, 31024 Toulouse, France
Interests: nutrition; brain; metabolism; gut-brain axis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Modern societies are characterized by aging populations. With aging, numerous disorders are also showing a quick expansion, including neurological disorders especially neurodegenerative diseases. Noteworthily, metabolic disorders have been associated with an increased risk of numerous neurological disorders. However, the clear link between both metabolic and brain disorders is yet to be elucidated. Indeed, although an increasing number of research articles describe the interplay between energy homeostasis and brain function, the mechanisms at play are still hypothetical.

In this special issue, we aim to assemble articles and reviews addressing this particular relationship linking metabolism and neurological disorders. In addition, to provide a recent picture of the state of the art we are also aiming to present new concepts and mechanisms identified, as well as future tracks to follow to improve the understanding of this special topic.

Specific areas include but are not limited to Nutrient sensing, gut brain axis, brain energetics, brain control of energy homeostasis, obesity and diabetes, neurological disorders, and nutrition.

Dr. Lionel Carneiro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • brain
  • aging
  • neurodegenerative disorders
  • brain disorders
  • nutrient sensing
  • gut brain axis
  • obesity
  • diabetes

Published Papers (2 papers)

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12 pages, 6431 KiB  
Article
Expression of Transferrin Protein and Messenger RNA in Neural Cells from Mouse and Human Brain Tissue
by Eriko Abe, Takashi J. Fuwa, Kyoka Hoshi, Takashi Saito, Takenobu Murakami, Masakazu Miyajima, Norihiro Ogawa, Hiroyasu Akatsu, Yoshio Hashizume, Yasuhiro Hashimoto and Takashi Honda
Metabolites 2022, 12(7), 594; https://doi.org/10.3390/metabo12070594 - 26 Jun 2022
Cited by 2 | Viewed by 1631
Abstract
Iron is an essential nutrient in the body. However, iron generates oxidative stress and hence needs to be bound to carrier proteins such as the glycoprotein transferrin (Tf) in body fluids. We previously reported that cerebrospinal fluid contains Tf glycan-isoforms that are derived [...] Read more.
Iron is an essential nutrient in the body. However, iron generates oxidative stress and hence needs to be bound to carrier proteins such as the glycoprotein transferrin (Tf) in body fluids. We previously reported that cerebrospinal fluid contains Tf glycan-isoforms that are derived from the brain, but their origins at the cellular level in the brain have not yet been elucidated. In the present report, we described the localization of Tf protein and mRNA in mouse and human brain tissue. In situ hybridization of mouse brain tissue revealed that Tf mRNA is expressed by different cell types such as epithelial cells in the choroid plexus, oligodendrocyte-like cells in the medulla, and neurons in the cortex, hippocampus, and basal ganglia. In contrast, Tf protein was barely detected by immunohistochemistry in hippocampal and some cortical neurons, but it was detected in other types of cells such as oligodendrocyte-like cells and choroid plexus epithelial cells. The results showed that Tf mRNA is expressed by neural cells, while Tf protein is expressed in different brain regions, though at very low levels in hippocampal neurons. Low Tf level in the hippocampus may increases susceptibility to iron-induced oxidative stress, and account for neuron death in neurodegenerative diseases. Full article
(This article belongs to the Special Issue The Link between Metabolism and Neurological Disorders)
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16 pages, 1733 KiB  
Article
Camu-Camu Reduces Obesity and Improves Diabetic Profiles of Obese and Diabetic Mice: A Dose-Ranging Study
by Anne Abot, Amandine Brochot, Nicolas Pomié, Eve Wemelle, Céline Druart, Marion Régnier, Nathalie M. Delzenne, Willem M. de Vos, Claude Knauf and Patrice D. Cani
Metabolites 2022, 12(4), 301; https://doi.org/10.3390/metabo12040301 - 29 Mar 2022
Cited by 7 | Viewed by 2655
Abstract
Overweight, obesity, and their comorbidities are currently considered a major public health concern. Today considerable efforts are still needed to develop efficient strategies able to attenuate the burden of these diseases. Nutritional interventions, some with plant extracts, present promising health benefits. In this [...] Read more.
Overweight, obesity, and their comorbidities are currently considered a major public health concern. Today considerable efforts are still needed to develop efficient strategies able to attenuate the burden of these diseases. Nutritional interventions, some with plant extracts, present promising health benefits. In this study, we evaluated the action of Camu-Camu (Myrciaria dubia), an Amazonian fruit rich in polyphenols and vitamin C, on the prevention of obesity and associated disorders in mice and the abundance of Akkermansia muciniphila in both cecum and feces. Methods: We investigated the dose-response effects of Camu-Camu extract (CCE) in the context of high-fat-diet (HFD)-induced obesity. After 5 weeks of supplementation, we demonstrated that the two doses of CCE differently improved glucose and lipid homeostasis. The lowest CCE dose (62.5 mg/kg) preferentially decreased non-HDL cholesterol and free fatty acids (FFA) and increased the abundance of A. muciniphila without affecting liver metabolism, while only the highest dose of CCE (200 mg/kg) prevented excessive body weight gain, fat mass gain, and hepatic steatosis. Both doses decreased fasting hyperglycemia induced by HFD. In conclusion, the use of plant extracts, and particularly CCE, may represent an additional option in the support of weight management strategies and glucose homeostasis alteration by mechanisms likely independent from the modulation of A. muciniphila abundance. Full article
(This article belongs to the Special Issue The Link between Metabolism and Neurological Disorders)
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