Neurodegenerative Disorders and Metabolism of the Aging Brain
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 6642
Special Issue Editor
Special Issue Information
Dear Colleagues,
Recent findings suggest the existence of a single pathomechanism of neurodegeneration—the disrupted neuronal metabolism mainly due to deficient energy homeostasis. Activity-dependent metabolic rate adjustment is a fundamental mechanism of cellular and tissue physiology that gets disabled, and vital neuronal processes and activities are progressively extinguished. The energy deficit promotes proteinopathies, which in turn conquer the cellular metabolism due to the accumulation of misfolded proteins accompanied by changes in the intracellular environment. We have just started to interpret neurodegenerative diseases as initiated by metabolic age-related dysfunction. The dysfunction appears to be preprogrammed, and the age-related crisis strikes the weakest and the most sensitive points of the nervous system. Without doubt, the present search for new effective therapies should focus on brain metabolism. The rationale for the search strongly is supported by a comprehensive concept that connects neuronal energy metabolism to the control of aging and longevity of the human brain. For instance, several studies have demonstrated the therapeutic potential of supplementing intermediates of nicotinamide adenine dinucleotide, such as nicotinamide riboside, providing a proof of concept for the development of an effective intervention. In this Special Issue, we aim to summarize our up-to-date knowledge of the pathological processes occurring in the aging brain and to open up a new perspective in the struggle with neurodegenerative disorders.
Prof. Janusz Błaszczyk
Guest Editor
Manuscript Submission Information
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Keywords
- Brain metabolism
- Aging processes in the brain
- Neurodegeneration
- Neuronal death
- Neurodegenerative disorders
- Therapeutic strategies
- Protective strategies
