Metabolomics Study in Women Health

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 3520

Special Issue Editors


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Guest Editor
Oakland University William Beaumont School of Medicine, Rochester, MI, USA
Interests: prenatal prediction; Alzheimer’s disease; Parkinson’s disease; metabolism
Department of Obstetrics and Gynecology, Oakland University-William Beaumont School of Medicine, Royal Oak, MI 48309, USA
Interests: metabolomics; lipidomics; mass spectrometry; nuclear magnetic resonance
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Special Issue Information

Dear Colleagues,

In the last decade metabolomics has emerged as a powerful analytical tool for elucidating disease pathogenesis. Further, it has proven particularly useful in generating biomarkers for the early stage of diseases. The combination of knowledge of disease pathogenesis and early and accurate biomarkers are pivotal to advancing the objectives of Precision Medicine and lays the groundwork for the development of novel therapies.

Unlike most compound-specific analyses of traditional clinical chemistry, metabolomics permits global and unbiased probing of the metabolome, and offers deeper insights into biological processes in normal and disease states. Unfortunately, Women’s Health has historically been a late beneficiary of breakthroughs in the sciences. Given the fact that women constitute roughly half of the population and more importantly influence the health and well-being of all fetuses and well into adulthood-  this is a doubly unfortunate reality which requires urgent redress!  Pregnancy disorders are characterized by enormous pathogenic complexity. This makes them ideally suited for metabolomic interrogation! The same can be said of other disorders of women such as gynecologic cancers. The deployment of metabolomic tools to address the challenges of Women’s Health must therefore be urgently encouraged.  Common disorders in pregnant and non-pregnant women such as premature cervical shortening, fetal growth restriction, Miscarriage, ectopic pregnancy, prematurity, preeclampsia, gestational diabetes, Cervical Cancer, Endometrial Cancer, Ovarian Cancer, Breast Cancer, PID, and Pelvic disorders are ripe for investigation using this powerful platform.

In this special issue entitled “Metabolomics in Women’s Health” the journal ‘Metabololites’ issues a call for manuscripts that uses metabolomic approaches to probe and answer pressing questions in Women’s Health. It is hoped that responses will span the spectrum from mechanistic insights into model systems to translational and clinical studies. Reviews and perspectives as well as original data are welcome. We hope this special issue will build on preexisting pioneering work in this consequential scientific area and serve to heighten interest and energize both new and established researchers working in the field Women’s Health.

Dr. Ray Bahado-Singh
Dr. Ali Yilmaz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biomarker
  • Women’s Health
  • Obstetric disorders
  • Pathophysiology
  • Geriatric Cancers

Published Papers (1 paper)

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Research

22 pages, 2107 KiB  
Article
Diabetes Leads to Alterations in Normal Metabolic Transitions of Pregnancy as Revealed by Time-Course Metabolomics
by Jacquelyn M. Walejko, Anushka Chelliah, Maureen Keller-Wood, Clive Wasserfall, Mark Atkinson, Anthony Gregg and Arthur S. Edison
Metabolites 2020, 10(9), 350; https://doi.org/10.3390/metabo10090350 - 27 Aug 2020
Cited by 20 | Viewed by 3117
Abstract
Women with diabetes during pregnancy are at increased risk of poor maternal and neonatal outcomes. Despite this, the effects of pre-gestational (PGDM) or gestational diabetes (GDM) on metabolism during pregnancy are not well understood. In this study, we utilized metabolomics to identify serum [...] Read more.
Women with diabetes during pregnancy are at increased risk of poor maternal and neonatal outcomes. Despite this, the effects of pre-gestational (PGDM) or gestational diabetes (GDM) on metabolism during pregnancy are not well understood. In this study, we utilized metabolomics to identify serum metabolic changes in women with and without diabetes during pregnancy and the cord blood at birth. We observed elevations in tricarboxylic acid (TCA) cycle intermediates, carbohydrates, ketones, and lipids, and a decrease in amino acids across gestation in all individuals. In early gestation, PGDM had elevations in branched-chain amino acids and sugars compared to controls, whereas GDM had increased lipids and decreased amino acids during pregnancy. In both GDM and PGDM, carbohydrate and amino acid pathways were altered, but in PGDM, hemoglobin A1c and isoleucine were significantly increased compared to GDM. Cord blood from GDM and PGDM newborns had similar increases in carbohydrates and choline metabolism compared to controls, and these alterations were not maternal in origin. Our results revealed that PGDM and GDM have distinct metabolic changes during pregnancy. A better understanding of diabetic metabolism during pregnancy can assist in improved management and development of therapeutics and help mitigate poor outcomes in both the mother and newborn. Full article
(This article belongs to the Special Issue Metabolomics Study in Women Health)
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