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Metabolites
Special Issues
Metabolome and Fluxomics
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Metabolome and Fluxomics

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Integrative Metabolomics".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 5455

Special Issue Editor

Prof. Josep J. Centelles

E-Mail Website1 Website2 Website3
Guest Editor
Departament de Bioquímica I Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Avda. Diagonal 643, 08028-Barcelona, Catalonia, Spain
Interests: metabolism; enzyme kinetics; receptors; transporters

Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to this Special Issue on metabolomics and fluxomics, with a special focus on energetic pathways and secondary metabolism. The main interest of the issue is related to the pathway’s controlling steps. For enzymes, it is crucial to know methods to analyze the activity of controlling enzymes, and their kinetic parameters (including maximal velocity, which is related to fluxomic of the complete metabolic pathway). Nevertheless, controlling steps include not only enzymes, but also transporters and receptors. Considering that controlling steps regulate metabolic pathways, inhibitors of those enzymes would reduce the flux of the step and therefore flux in the complete pathway. You are welcome to chare your recent results in this monographic issue.

Prof. Josep J. Centelles
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Metabolism
  • Enzymes
  • Receptors
  • Transporters
  • Inhibitors
  • Kinetic parameters
  • Metabolic pathways

Published Papers (1 paper)

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Research

20 pages, 12555 KiB  
Article
Using Community Science to Reveal the Global Chemogeography of River Metabolomes
by Vanessa A. Garayburu-Caruso, Robert E. Danczak, James C. Stegen, Lupita Renteria, Marcy Mccall, Amy E. Goldman, Rosalie K. Chu, Jason Toyoda, Charles T. Resch, Joshua M. Torgeson, Jacqueline Wells, Sarah Fansler, Swatantar Kumar and Emily B. Graham
Metabolites 2020, 10(12), 518; https://doi.org/10.3390/metabo10120518 - 20 Dec 2020
Cited by 21 | Viewed by 4945
Abstract
River corridor metabolomes reflect organic matter (OM) processing that drives aquatic biogeochemical cycles. Recent work highlights the power of ultrahigh-resolution mass spectrometry for understanding metabolome composition and river corridor metabolism. However, there have been no studies on the global chemogeography of surface water [...] Read more.
River corridor metabolomes reflect organic matter (OM) processing that drives aquatic biogeochemical cycles. Recent work highlights the power of ultrahigh-resolution mass spectrometry for understanding metabolome composition and river corridor metabolism. However, there have been no studies on the global chemogeography of surface water and sediment metabolomes using ultrahigh-resolution techniques. Here, we describe a community science effort from the Worldwide Hydrobiogeochemistry Observation Network for Dynamic River Systems (WHONDRS) consortium to characterize global metabolomes in surface water and sediment that span multiple stream orders and biomes. We describe the distribution of key aspects of metabolomes including elemental groups, chemical classes, indices, and inferred biochemical transformations. We show that metabolomes significantly differ across surface water and sediment and that surface water metabolomes are more rich and variable. We also use inferred biochemical transformations to identify core metabolic processes shared among surface water and sediment. Finally, we observe significant spatial variation in sediment metabolites between rivers in the eastern and western portions of the contiguous United States. Our work not only provides a basis for understanding global patterns in river corridor biogeochemical cycles but also demonstrates that community science endeavors can enable global research projects that are unfeasible with traditional research models. Full article
(This article belongs to the Special Issue Metabolome and Fluxomics)
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