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Metabolites
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Muscle Metabolic Response and Adaptation to Exercise, Diet, and Environment
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Muscle Metabolic Response and Adaptation to Exercise, Diet, and Environment

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Animal Metabolism".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 2862

Special Issue Editor

Dr. Susumu Muroya

E-Mail Website
Guest Editor
NARO Institute of Livestock and Grassland Science, Tsukuba, Ibaraki, Japan
Interests: muscle biology; meat biochemistry; epigenetics; metabolomics; animal science

Special Issue Information

Dear Colleagues,

Skeletal muscle plays a crucial role as a locomotor organ and as a modulator of systemic energy homeostasis in animals. Dysregulation of muscle metabolism in humans leads to the development of serious diseases such as diabetes and sarcopenia. In farm animals, excessive pursuit of productivity sometimes causes disruption of energy homeostasis as exhibited in undesirable products such as abnormal chicken meat quality derived from disturbed mitophagy and/or redox metabolism. The optimized muscle metabolism is important for an increase in muscle mass during animal development and growth. Therefore, a better understanding of mechanisms underlying developmental regulation of metabolisms and adaptation of skeletal muscle metabolism to various inputs including diet, exercise, and environment stress contributes to further improvement of human health, animal welfare and productivity, and meat quality.

Recent metabolomics technologies, in combination with the development of bioinformatics and imaging mass spectrometry, has provided great benefits in the approach to unexplored muscle metabolisms. With these backgrounds, this Special Issue aims to share and discuss research topics focusing on molecular mechanisms of the metabolic response of skeletal muscle tissue and cells in the view of genes, transcripts, proteins, metabolites, and epigenetic factors, when exposed to various nutritional conditions and physiological stress-inducing environments. Papers addressing mechanisms of metabolic adaptation and disturbance, especially in terms of mitochondria, energy homeostasis, lipid metabolism, and redox metabolism, including cell culture studies, could be the desired topics in this issue. Meanwhile, other studies regarding skeletal muscle growth, maturation, aging, disease, and farm animal intramuscular fat and postmortem muscle aging are also welcome. Most of these studies may be conducted by use of metabolomics and integrative multi-omics approaches, but also cutting-edge studies targeting a specific key metabolite and inter-organ crosstalk around muscle in the above-mentioned fields are also acceptable.

Dr. Susumu Muroya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skeletal muscle
  • metabolomics
  • mitochondria
  • energy metabolism
  • lipid metabolism
  • nutrition
  • feeding
  • environment
  • exercise
  • stress

Published Papers (2 papers)

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Research

18 pages, 5035 KiB  
Article
Depth of Interbreed Difference in Postmortem Bovine Muscle Determined by CE-FT/MS and LC-FT/MS Metabolomics
by Susumu Muroya, Yuta Horiuchi, Kazuki Iguchi, Takuma Higuchi, Shuji Sakamoto, Koichi Ojima and Kazutsugu Matsukawa
Metabolites 2024, 14(5), 261; https://doi.org/10.3390/metabo14050261 - 01 May 2024
Viewed by 275
Abstract
Japanese Brown (JBR) cattle have moderately marbled beef compared to the highly marbled beef of Japanese Black (JBL) cattle; however, their skeletal muscle properties remain poorly characterized. To unveil interbreed metabolic differences over the previous results, we explored the metabolome network changes before [...] Read more.
Japanese Brown (JBR) cattle have moderately marbled beef compared to the highly marbled beef of Japanese Black (JBL) cattle; however, their skeletal muscle properties remain poorly characterized. To unveil interbreed metabolic differences over the previous results, we explored the metabolome network changes before and after postmortem 7-day aging in the trapezius muscle of the two cattle breeds by employing a deep and high-coverage metabolomics approach. Using both capillary electrophoresis (CE) and ultra-high-performance liquid chromatography (UHPLC)–Fourier transform mass spectrometry (FT/MS), we detected 522 and 384 annotated peaks, respectively, across all muscle samples. The CE-based results showed that the cattle were clearly separated by breed and postmortem age in multivariate analyses. The metabolism related to glutathione, glycolysis, vitamin K, taurine, and arachidonic acid was enriched with differentially abundant metabolites in aged muscles, in addition to amino acid (AA) metabolisms. The LC-based results showed that the levels of bile-acid-related metabolites, such as tauroursodeoxycholic acid (TUDCA), were high in fresh JBR muscle and that acylcarnitines were enriched in aged JBR muscle, compared to JBL muscle. Postmortem aging resulted in an increase in fatty acids and a decrease in acylcarnitine in the muscles of both cattle breeds. In addition, metabolite set enrichment analysis revealed that JBR muscle was distinctive in metabolisms related to pyruvate, glycerolipid, cardiolipin, and mitochondrial energy production, whereas the metabolisms related to phosphatidylethanolamine, nucleotide triphosphate, and AAs were characteristic of JBL. This suggests that the interbreed differences in postmortem trapezius muscle are associated with carnitine/acylcarnitine transport, β-oxidation, tricarboxylic acid cycle, and mitochondrial membrane stability, in addition to energy substrate and AA metabolisms. These interbreed differences may characterize beef quality traits such as the flavor intensity and oxidative stability. Full article
(This article belongs to the Special Issue Muscle Metabolic Response and Adaptation to Exercise, Diet, and Environment)
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15 pages, 3475 KiB  
Article
Moderate Effects of Hypoxic Training at Low and Supramaximal Intensities on Skeletal Muscle Metabolic Gene Expression in Mice
by Svitlana Drozdovska, Nadège Zanou, Jessica Lavier, Lucia Mazzolai, Grégoire P. Millet and Maxime Pellegrin
Metabolites 2023, 13(10), 1103; https://doi.org/10.3390/metabo13101103 - 21 Oct 2023
Viewed by 2178
Abstract
The muscle molecular adaptations to different exercise intensities in combination with hypoxia are not well understood. This study investigated the effect of low- and supramaximal-intensity hypoxic training on muscle metabolic gene expression in mice. C57BL/6 mice were divided into two groups: sedentary and [...] Read more.
The muscle molecular adaptations to different exercise intensities in combination with hypoxia are not well understood. This study investigated the effect of low- and supramaximal-intensity hypoxic training on muscle metabolic gene expression in mice. C57BL/6 mice were divided into two groups: sedentary and training. Training consisted of 4 weeks at low or supramaximal intensity, either in normoxia or hypoxia (FiO2 = 0.13). The expression levels of genes involved in the hypoxia signaling pathway (Hif1a and Vegfa), the metabolism of glucose (Gys1, Glut4, Hk2, Pfk, and Pkm1), lactate (Ldha, Mct1, Mct4, Pdh, and Pdk4) and lipid (Cd36, Fabp3, Ucp2, Hsl, and Mcad), and mitochondrial energy metabolism and biogenesis (mtNd1, mtNd6, CytC, CytB, Pgc1a, Pgc1β, Nrf1, Tfam, and Cs) were determined in the gastrocnemius muscle. No physical performance improvement was observed between groups. In normoxia, supramaximal intensity training caused upregulation of major genes involved in the transport of glucose and lactate, fatty acid oxidation, and mitochondrial biogenesis, while low intensity training had a minor effect. The exposure to hypoxia changed the expression of some genes in the sedentary mice but had a moderate effect in trained mice compared to respective normoxic mice. In hypoxic groups, low-intensity training increased the mRNA levels of Mcad and Cs, while supramaximal intensity training decreased the mRNA levels of Mct1 and Mct4. The results indicate that hypoxic training, regardless of exercise intensity, has a moderate effect on muscle metabolic gene expression in healthy mice. Full article
(This article belongs to the Special Issue Muscle Metabolic Response and Adaptation to Exercise, Diet, and Environment)
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