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Metabolites
Special Issues
Immunometabolism 2019
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Immunometabolism 2019

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (31 May 2020) | Viewed by 5627

Special Issue Editor

Dr. Ujjwal Neogi

E-Mail Website
Guest Editor
Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, 14186 Stockholm, Sweden
Interests: multi-omics; healthy-aging; data integration; infectious diseases; HIV/AIDS

Special Issue Information

Dear Colleagues,

Systems biology approaches are increasingly implemented in biomedical research, and scientific disciplines are getting more and more diversified. Over the past decade, the improvement and development of new omics technologies have notably improved personalized medicine, in prevention or treatment settings, by providing a broad range of information ranging from genetics to metabolites. Immunometabolism has revolutionized the translational research. The immune response is regulated by host metabolites, metabolites derived from the microbiota, and infectious agents. Discoveries of the crosstalk between the metabolite and immune cells are paving the way for novel therapies for chronic inflammatory and autoimmune diseases, as well as for cancer immunotherapies. This Special Issue of Metabolites, entitled "Immunometabolism," will be focused, but not restricted to, the latest development and discoveries of immunometabolism studies in chronic infection, autoimmune diseases, and cancer. We encourage the submission of papers that include multidisciplinary approaches and techniques focusing on basic and translation research about the mechanisms and regulation of metabolism.

Dr. Ujjwal Neogi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Immunometabolism
  • Multi-omics
  • Chronic infection and cancer
  • Translational research

Published Papers (1 paper)

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Research

16 pages, 4720 KiB  
Article
Plasma Metabolic Signature and Abnormalities in HIV-Infected Individuals on Long-Term Successful Antiretroviral Therapy
by Hemalatha Babu, Maike Sperk, Anoop T. Ambikan, Gladys Rachel, Vinod Kumar Viswanathan, Srikanth P. Tripathy, Piotr Nowak, Luke Elizabeth Hanna and Ujjwal Neogi
Metabolites 2019, 9(10), 210; https://doi.org/10.3390/metabo9100210 - 30 Sep 2019
Cited by 40 | Viewed by 5075
Abstract
Targeted metabolomics studies reported metabolic abnormalities in both treated and untreated people living with human immunodeficiency virus (HIV) (PLHIV). The present study aimed to understand the plasma metabolomic changes and predicted the risk of accelerated aging in PLHIV on long-term suppressive antiretroviral therapy [...] Read more.
Targeted metabolomics studies reported metabolic abnormalities in both treated and untreated people living with human immunodeficiency virus (HIV) (PLHIV). The present study aimed to understand the plasma metabolomic changes and predicted the risk of accelerated aging in PLHIV on long-term suppressive antiretroviral therapy (ART) in a case-control study setting and its association with the plasma proteomics biomarkers of inflammation and neurological defects. Plasma samples were obtained from PLHIV on successful long-term ART for more than five years (n = 22) and matched HIV-negative healthy individuals (n = 22, HC herein). Untargeted metabolite profiling was carried out using ultra-high-performance liquid chromatography/mass spectrometry/mass spectrometry (UHPLC/MS/MS). Plasma proteomics profiling was performed using proximity extension assay targeting 184 plasma proteins. A total of 250 metabolites differed significantly (p < 0.05, q < 0.1) between PLHIV and HC. Plasma levels of several essential amino acids except for histidine, branched-chain amino acids, and aromatic amino acids (phenylalanine, tyrosine, tryptophan) were significantly lower in PLHIV compared to HC. Machine-learning prediction of metabolite changes indicated a higher risk of inflammatory and neurological diseases in PLHIV. Metabolic abnormalities were observed in amino-acid levels, energetics, and phospholipids and complex lipids, which may reflect known differences in lipoprotein levels in PLHIV that can resemble metabolic syndrome (MetS). Full article
(This article belongs to the Special Issue Immunometabolism 2019)
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