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Metabolites
Special Issues
Mitochondria in the Lipid Metabolism
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Mitochondria in the Lipid Metabolism

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 2022

Special Issue Editors

Dr. Jing Tian

E-Mail Website
Guest Editor
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
Interests: lifespan; metabolism; Caenorhabditis elegans
Prof. Dr. Zebo Huang

E-Mail Website
Guest Editor
School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China
Interests: food nutrition and health; active polysaccharides and peptides; aging and related diseases

Special Issue Information

Dear Colleagues,

Mitochondrion is a central actor in the maintenance of energy conversion homeostasis that are altered in adipose formation and obestiy. Multiple mechanisms regarding the communication of mitochondrial fitness and the cellular functions or dysregulations have been reported in the process of lipid metabolism. The need for a better understanding of the molecular and microenviromental cues that defines the role of mitochondria in those process is highlighted while the controdicted evidences were accumulated.

The Special Issue of Mitochondria in the Lipid Metabolism will publish reviews and original articles covering the lastest findings of mitochondrial metabolic strategies contributing to the maintainance of lipid metabolism homeostasis. In addtion, new measurement methods, bioinformatical tools and data analysis concepts are welcome.

Dr. Jing Tian
Prof. Dr. Zebo Huang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mitochondria
  • lipid metabolism
  • metabolites
  • metabolic analysis

Published Papers (1 paper)

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Research

17 pages, 4341 KiB  
Article
GLP-1 Receptor Agonist Improves Mitochondrial Energy Status and Attenuates Nephrotoxicity In Vivo and In Vitro
by Linxi Wang, Zhou Chen, Xiaoying Liu, Lijing Wang, Yu Zhou, Jingze Huang, Zhiqing Liu, Donghai Lin and Libin Liu
Metabolites 2023, 13(11), 1121; https://doi.org/10.3390/metabo13111121 - 01 Nov 2023
Viewed by 1557
Abstract
High-sugar and high-fat diets cause significant harm to health, especially via metabolic diseases. In this study, the protective effects of the antidiabetic drug exenatide (synthetic exendin-4), a glucagon-like peptide 1 (GLP-1) receptor agonist, on high-fat and high-glucose (HFHG)-induced renal injuries were investigated in [...] Read more.
High-sugar and high-fat diets cause significant harm to health, especially via metabolic diseases. In this study, the protective effects of the antidiabetic drug exenatide (synthetic exendin-4), a glucagon-like peptide 1 (GLP-1) receptor agonist, on high-fat and high-glucose (HFHG)-induced renal injuries were investigated in vivo and in vitro. In vivo and in vitro renal injury models were established. Metabolomic analysis based on 1H-nuclear magnetic resonance was performed to examine whether exenatide treatment exerts a protective effect against kidney injury in diabetic rats and to explore its potential molecular mechanism. In vivo, 8 weeks of exenatide treatment resulted in the regulation of most metabolites in the diabetes mellitus group. In vitro results showed that exendin-4 restored the mitochondrial functions of mesangial cells, which were perturbed by HFHG. The effects of exendin-4 included the improved antioxidant capacity of mesangial cells, increased the Bcl-2/Bax ratio, and reduced protein expression of cyt-c and caspase-3 activation. In addition, exendin-4 restored mesangial cell energy metabolism by increasing succinate dehydrogenase and phosphofructokinase activities and glucose consumption while inhibiting pyruvate dehydrogenase E1 activity. In conclusion, GLP-1 agonists improve renal injury in diabetic rats by ameliorating metabolic disorders. This mechanism could be partially related to mitochondrial functions and energy metabolism. Full article
(This article belongs to the Special Issue Mitochondria in the Lipid Metabolism)
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