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Metabolites
Special Issues
Circadian Clock Affects Lipid Metabolism and Cardiovascular Disease
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Circadian Clock Affects Lipid Metabolism and Cardiovascular Disease

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".

Deadline for manuscript submissions: closed (24 December 2022) | Viewed by 2068

Special Issue Editor

Dr. Xiaoyue Pan

E-Mail Website
Guest Editor
1. Department of Foundations of Medicine, New York University Long Island School of Medicine, Mineola, New York, NY 11501, USA
2. Diabetes and Obesity Research Center, NYU Winthrop Hospital, Mineola, New York, NY 11501, USA
Interests: circadian clock; lipid metabolism; glucose transport

Special Issue Information

Dear Colleagues,

Circadian clock genes are classes of functionally important circadian rhythm genes that regulate multiple tissues and cellular processes, including cell membrane organization, transport, migration, proliferation, and inflammatory as well as lipid-signaling pathways. Imbalances in circadian clock genes or circadian-clock-controlled genes result in dysregulated cellular processes in different tissues and lead to the development and progression of multiple disorders, including cardiovascular disease. This Special Issue will describe the regulation of lipid metabolism pathways of circadian clocks with a focus on the evidence linking circadian clock genes with the regulation of lipid metabolism, obesity, diabetes, metabolic syndrome diseases, and/or heart diseases. We will collect papers regarding molecular mechanisms of circadian clock dysregulation and their impact on lipid metabolism. We will further focus on how the modulation of circadian clock genes can be translated into new approaches for the treatment of cardiovascular disease and describe current clinical studies and basic studies that focus on circadian clock regulation in cardiovascular disease.

Dr. Xiaoyue Pan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • circadian clock
  • lipid metabolism
  • cells
  • tissue
  • lipoprotein
  • apolipoprotein
  • obesity
  • metabolic disease
  • diabetes
  • glucose
  • restricted feeding
  • nutrient
  • adipose tissue
  • shift-work
  • plasma lipidome
  • insulin sensitivity

Published Papers (1 paper)

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Research

13 pages, 1789 KiB  
Article
Differential Effect of Fructose in the Presence or Absence of Fatty Acids on Circadian Metabolism in Hepatocytes
by Shani Tsameret, Nava Chapnik and Oren Froy
Metabolites 2023, 13(2), 138; https://doi.org/10.3390/metabo13020138 - 17 Jan 2023
Viewed by 1693
Abstract
We aimed to explore whether fructose in the absence or presence of fatty acids modulates circadian metabolism in AML-12 hepatocytes. Fructose treatment under steatosis conditions (FruFA) led to fat synthesis resulting in increased triglycerides and cholesterol content. Fructose led to reduced activity of [...] Read more.
We aimed to explore whether fructose in the absence or presence of fatty acids modulates circadian metabolism in AML-12 hepatocytes. Fructose treatment under steatosis conditions (FruFA) led to fat synthesis resulting in increased triglycerides and cholesterol content. Fructose led to reduced activity of the AMPK and mTOR-signaling pathway. However, FruFA treatment led to inhibition of the AMPK signaling pathway but activation of the mTOR pathway. Fructose also increased the expression of inflammatory markers, whereas the addition of fatty acids dampened their circadian expression. At the clock level, fructose or FruFA altered the expression of the core clock. More specifically, fructose led to altered expression of the BMAL1-RORα-REV-ERBα axis, together with reduced phosphorylated BMAL1 levels. In conclusion, our results show that hepatocytes treated with fructose respond differently if fatty acids are present, leading to a differential effect on metabolism and circadian rhythms. This is achieved by modulating BMAL1 activity and expression. Full article
(This article belongs to the Special Issue Circadian Clock Affects Lipid Metabolism and Cardiovascular Disease)
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