Bioprocessing with Membranes: Filtration and Chromatography
Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 25674
Interests: bioprocess engineering; biopharmaceuticals; bioseparations; bioreactors; membrane processes
Special Issues, Collections and Topics in MDPI journals
Membrane filtration has been widely considered a useful separation technique, mainly due to the advantages it presents when compared to other separation techniques, both economically and regarding the quality of the recovered products. Applications can be found in a wide variety of industries, such as wastewater treatment or water production/reclamation, biorefineries, food and beverage, and biopharmaceutical sectors. The main purposes are removal of dispersions, pollutants or impurities, concentration of target products and recovery of byproducts from process streams, and retention of cells or other biocatalysts in continuous or perfused bioreactors. Major concerns in membrane filtration processes are still the impact of membrane fouling on the process performance, the implications of not selecting the best operation conditions or sequence of processes, and the energy and membrane cost requirements for processing. Which innovative strategies are thought to overcome these difficulties?
Chromatography is a fine-tuning separation method important for many bioprocesses, in which specific physical–chemical and affinity properties of the target products and of the respective impurities are addressed to meet effective separation and high purity in a final product when required. Membranes have been used as chromatographic solid matrices (e.g., adsorbers), particularly for the purification and polishing steps of large biomolecules, such as biopharmaceuticals. Which new membrane adsorbers are being developed or need development? Which novelties are proposed for membrane module design? Modeling and applications of continuous chromatography operation and the outputs of membrane column arrangements would probably be very insightful.
This Special Issue aims to cover the latest developments and innovations regarding membrane filtration and membrane chromatography operation and their systems for bioprocessing. Potential topics include but are not limited to the following:
- Fundamentals and applications—new approaches
- Batch and continuous processing strategies
- Up- and downstream process integration
- Membrane improvement for fouling control
- Development of membrane adsorbers
- Depth filtration with membranes
- Comparative performance of membrane materials/structures
- Membrane bioreactors
- Scale-up studies and scale-down devices
- Module design
- Process economics
- Modeling of membrane performance and membrane systems
Dr. Marília Mateus
Manuscript Submission Information
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