Peripheral Artery Disease in Diabetes: Prevention, Diagnosis and New Therapeutic Paradigms

Dear Colleagues,

Peripheral artery disease (PAD) in individuals with diabetes presents a multifaceted challenge that demands comprehensive prevention, early diagnosis and innovative therapeutic approaches. Diabetes is a major risk factor for PAD, characterized by progressive artery stenosis, particularly in limbs, leading to a reduced blood flow and the potential complications such as pain, ulcers and even amputation.

Prevention is pivotal in mitigating the impact of PAD in diabetic patients. Tight glycemic control, alongside lifestyle modifications including regular exercise and smoking cessation, plays a central role in averting the progression of arterial disease. Moreover, reducing cardiovascular risk is mandatory for these patients. Early detection through non-invasive diagnostic methods like ankle-brachial index (ABI) is crucial, enabling the timely intervention to impede the advancement of PAD. Furthermore, the emerging diagnostic technologies, such as advanced imaging modalities and artificial intelligence, promise an enhanced precision in identifying vascular atherosclerotic lesions.

In the realm of therapeutics, a paradigm shift is underway. Targeted pharmacological interventions and innovative revascularization techniques, including angioplasty and stent placement, offer new avenues for managing PAD in diabetes. Additionally, research into regenerative medicine and gene therapies holds promise for novel approaches to restore vascular health.

This Special Issue aims to attract original research and review articles interested in describing the complex interplay between diabetes and PAD, focusing on the importance of new strategies for cardiovascular risk control, emerging diagnostic tools and innovative therapeutic paradigms.

Dr. Giuseppe Miceli
Prof. Dr. Antonino Tuttolomondo
Guest Editors

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• peripheral artery disease
• diabetes
• atherosclerosis
• cardiovascular risk
• diabetic foot
• antithrombotic therapy
• oral hypoglycemic agents
• regenerative medicine
• artificial intelligence

1.  Current opinion on diagnosis of peripheral artery disease in diabetic patients

2. Effectiveness and Safety of Antidiabetic Drugs in Patients with Type 2 Diabetes and Peripheral Artery Disease: Systematic Review

3. Peripheral artery disease, platelets and diabetes: what link?