Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
3.4
Journals
Materials
Special Issues
Polymer Biomaterials for Bone Regeneration
materials-logo
Submit to Materials Review for Materials Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Polymer Biomaterials for Bone Regeneration

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 6874

Special Issue Editor

Prof. Dr. Takahiro Kanno

E-Mail Website
Guest Editor
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Shimane University, Shimane, Japan
Interests: oral and maxillofacial surgery; maxillofacial regeneration; biomaterial; maxillofacial reconstruction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymer-based biomaterials such as bioresorbable and biodegradable osteosynthetic fixation systems or boney reconstruction implant materials have recently been considered effective bone regenerative reconstruction systems that offer several advantages over conventional metal, titanium osteosynthetic fixation and bone reconstruction systems, including the absence of corrosion and of accumulation of metal in tissues and of the need to remove the implants after osseous healing in addition to radiolucency, decreased pain, and reduced stress-shielding as the implants initially bear a smaller load and gradually transfer this load as they degrade. The first study on the use of polymer-based biodegradable implants was published in 1966. Polymer-based biomaterials for boney osteosynthetic applications are currently becoming more common. These materials are safe, effective, and sufficiently flexible for use at many boney surgical sites. Furthermore, novel polymer-based biomaterial products and feasible modified systems have been widely introduced for clinical applications.

For this Special Issues, I would like to feature any original research from clinical studies as well as in vitro and in vivo studies, reviews, short reports, or opinion pieces from researchers interested in these research topics of “Polymer Biomaterials for Bone Regeneration”.

Prof. Dr. Takahiro Kanno
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral and maxillofacial surgery
  • bone regeneration
  • reconstruction
  • dentistry
  • biomaterial

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

21 pages, 14994 KiB  
Article
Bioactive Regeneration Potential of the Newly Developed Uncalcined/Unsintered Hydroxyapatite and Poly-l-Lactide-Co-Glycolide Biomaterial in Maxillofacial Reconstructive Surgery: An In Vivo Preliminary Study
by Shinji Ishizuka, Quang Ngoc Dong, Huy Xuan Ngo, Yunpeng Bai, Jingjing Sha, Erina Toda, Tatsuo Okui and Takahiro Kanno
Materials 2021, 14(9), 2461; https://doi.org/10.3390/ma14092461 - 10 May 2021
Cited by 4 | Viewed by 2123
Abstract
Uncalcined/unsintered hydroxyapatite (HA) and poly-l-lactide-co-glycolide (u-HA/PLLA/PGA) are novel bioresorbable bioactive materials with bone regeneration characteristics and have been used to treat mandibular defects in a rat model. However, the bone regenerative interaction with the periosteum, the inflammatory response, and the degradation [...] Read more.
Uncalcined/unsintered hydroxyapatite (HA) and poly-l-lactide-co-glycolide (u-HA/PLLA/PGA) are novel bioresorbable bioactive materials with bone regeneration characteristics and have been used to treat mandibular defects in a rat model. However, the bone regenerative interaction with the periosteum, the inflammatory response, and the degradation of this material have not been examined. In this study, we used a rat mandible model to compare the above features in u-HA/PLLA/PGA and uncalcined/unsintered HA and poly-l-lactic acid (u-HA/PLLA). We divided 11 male Sprague–Dawley rats into 3- and 16-week groups. In each group, we assessed the characteristics of a u-HA/PLLA/PGA sheet covering the right mandibular angle and a u-HA/PLLA sheet covering the left mandibular angle in three rats each, and one rat was used as a sham control. The remaining three rats in the 16-week group were used for a degradation assessment and received both sheets of material as in the material assessment subgroup. At 3 and 16 weeks after surgery, the rats were sacrificed, and mandible specimens were subjected to micro-computed tomography, histological analysis, and immunohistochemical staining. The results indicated that the interaction between the periosteum and u-HA/PLLA/PGA material produced significantly more new bone regeneration with a lower inflammatory response and a faster resorption rate compared to u-HA/PLLA alone. These findings may indicate that this new biomaterial has ideal potential in treating maxillofacial defects of the midface and orbital regions. Full article
(This article belongs to the Special Issue Polymer Biomaterials for Bone Regeneration)
►▼ Show Figures

Figure 1

9 pages, 1977 KiB  
Article
Bone Coverage around Hydroxyapatite/Poly(L-Lactide) Composite Is Determined According to Depth from Cortical Bone Surface in Rabbits
by Kazuaki Morizane, Koji Goto, Toshiyuki Kawai, Shunsuke Fujibayashi, Bungo Otsuki, Takayoshi Shimizu and Shuichi Matsuda
Materials 2021, 14(6), 1458; https://doi.org/10.3390/ma14061458 - 17 Mar 2021
Cited by 1 | Viewed by 1519
Abstract
Composites of unsintered hydroxyapatite (HA) and poly(L-lactide) (PLLA) reinforced by compression forging are biodegradable, bioactive, and have ultrahigh strength. However, foreign body reactions to PLLA and physical irritation can occur when not covered by bone. We aimed to confirm the relationships [...] Read more.
Composites of unsintered hydroxyapatite (HA) and poly(L-lactide) (PLLA) reinforced by compression forging are biodegradable, bioactive, and have ultrahigh strength. However, foreign body reactions to PLLA and physical irritation can occur when not covered by bone. We aimed to confirm the relationships between the depth of the implanted HA-PLLA threaded pins and the new bone formation. We inserted HA-PLLA composite threaded pins (diameter: 2.0 or 4.5 mm) into the femoral and tibial bones of 32 mature male Japanese white rabbits (weight 3.0–3.5 kg) with the pin head 1 or 0 mm below or protruding 1 or 2 mm above surrounding cortical bone. Eight euthanized rabbits were radiologically and histologically assessed at various intervals after implantation. Bone bridging was complete over pins of both diameters at ~12 weeks, when inserted 1 mm below the surface, but the coverage of the pins inserted at 0 mm varied. Bone was not formed when the pins protruded >1 mm from the bone surface. No inflammation developed around the pins by 25 weeks. However, foreign body reactions might develop if composites are fixed above the bone surface, and intraosseous fixation would be desirable using double-threaded screws or a countersink to avoid screw head protrusion. Full article
(This article belongs to the Special Issue Polymer Biomaterials for Bone Regeneration)
►▼ Show Figures

Figure 1

12 pages, 3397 KiB  
Article
Biomechanical Loading Comparison between Titanium and Bioactive Resorbable Screw Systems for Fixation of Intracapsular Condylar Head Fractures
by Shintaro Sukegawa, Norio Yamamoto, Keisuke Nakano, Kiyofumi Takabatake, Hotaka Kawai, Takahiro Kanno, Hitoshi Nagatsuka and Yoshihiko Furuki
Materials 2020, 13(14), 3153; https://doi.org/10.3390/ma13143153 - 15 Jul 2020
Cited by 6 | Viewed by 2667
Abstract
Osteosynthesis resorbable materials made of uncalcined and unsintered hydroxyapatite (u-HA) particles, poly-L-lactide (PLLA), are bioresorbable, and these materials have feasible bioactive/osteoconductive capacities. However, their strength and stability for fixation in mandibular condylar head fractures remain unclear. This in vitro study aimed to assess [...] Read more.
Osteosynthesis resorbable materials made of uncalcined and unsintered hydroxyapatite (u-HA) particles, poly-L-lactide (PLLA), are bioresorbable, and these materials have feasible bioactive/osteoconductive capacities. However, their strength and stability for fixation in mandibular condylar head fractures remain unclear. This in vitro study aimed to assess the biomechanical strength of u-HA/PLLA screws after the internal fixation of condylar head fractures. To evaluate their biomechanical behavior, 32 hemimandible replicas were divided into eight groups, each consisting of single-screw and double-screw fixations with titanium or u-HA/PLLA screws. A linear load was applied as vertical and horizontal load to each group to simulate the muscular forces in condylar head fractures. Samples were examined for 0.5, 1, 2, and 3-mm displacement loads. Two screws were needed for stable fixation of the mandibular condylar head fracture during biomechanical evaluation. After screw fixation for condylar head fractures, the titanium screws model was slightly more resistant to vertical and horizontal movement with a load for a small displacement than the u-HA/PLLA screws model. There was no statistically significant difference with load for large displacements. The u-HA/PLLA screw has a low mechanical resistance under small displacement loading compared with titanium within the limits of the mandibular head fracture model study. Full article
(This article belongs to the Special Issue Polymer Biomaterials for Bone Regeneration)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop