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Biomaterials Performance in Clinical Cases and Failure Analysis of Implants
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Biomaterials Performance in Clinical Cases and Failure Analysis of Implants

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 13657

Special Issue Editors

Prof. Dr. Iulian Vasile Antoniac

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Guest Editor
Faculty of Material Science and Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, Romania
Interests: biodegradable metallic biomaterials; medical devices; surface modification; tissue–biomaterials interaction; bioceramics; biocomposites; biointerfaces; tissue engineering; bone regeneration; retrieval and failure analysis of orthopedic and dental implants
Special Issues, Collections and Topics in MDPI journals
Assoc. Prof. Costache Victor Sebastian

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Guest Editor
University Lucian Blaga Sibiu, Faculty of Medicine
Interests: cardiovascular surgery; endovascular aortic repair; implants; clinical application of biomaterials

Special Issue Information

Dear colleagues,

The goal of this Special Issue is to provide material scientists and clinicians from various clinical specializations with more information and data about biomaterials analysis from an engineering point of view, as well as their clinical performance in medicine.

There is a wide range of biomaterials used for different clinical applications in medicine, from metallic alloys to ceramics and from polymers to hybrid composites. Functional properties play an important role in discussions about their clinical applications and in the evaluation of clinical performance for different implants and prostheses. This Special Issue also focuses on the current strategies for human tissue repair and regeneration. Based on the requirements of modern biomedical technology, novel research strategies in biomaterials field are today directed toward biomaterials endowed with surface properties, controlled adhesion, and for the controlled release of active principles, especially against infections.

On the other hand, the continuous analysis and monitoring of the clinical results obtained after the use of implants and prosthesis clearly represent a good way to establish new research directions and develop new solutions for future biomaterials. In this view, several research groups and clinicians from various medical specializations have been invited to contribute to this Special Issue with their original research papers that could stimulate efforts of comprehensive knowledge of new biomaterials and technology for medicine.

This Special Issue of Materials will collect original high-quality research papers covering the most recent advances and comprehensive reviews addressing state-of-the-art topics related to the biomaterials performance in clinical cases and failure analysis of implants.

Prof. Habil. Antoniac Iulian
Assoc. Prof. Costache Victor Sebastian
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biomaterials
  • Failure analysis
  • Clinical application of biomaterials
  • Surface analysis
  • Clinical studies
  • Biomaterials–tissue interface

Published Papers (5 papers)

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Research

18 pages, 10970 KiB  
Article
Adhesive-Ceramic Interface Behavior in Dental Restorations. FEM Study and SEM Investigation
by Otilia Chirca, Cornelia Biclesanu, Anamaria Florescu, Dan Ioan Stoia, Anna Maria Pangica, Alexandru Burcea, Marius Vasilescu and Iulian Vasile Antoniac
Materials 2021, 14(17), 5048; https://doi.org/10.3390/ma14175048 - 3 Sep 2021
Cited by 5 | Viewed by 2156
Abstract
The purpose of this study is to identify the stress levels that act in inlay and onlay restorations, according to the direction and value of the external force applied. The study was conducted using the Finite Element Method (FEM) of three types of [...] Read more.
The purpose of this study is to identify the stress levels that act in inlay and onlay restorations, according to the direction and value of the external force applied. The study was conducted using the Finite Element Method (FEM) of three types of ceramics: pressed lithium disilicate and monolith, zirconia, and three different adhesive systems: self-adhesive, universal, and dual-cure cements. In addition to FEM, the inlay/onlay-dental structure interface analysis was performed by means of Scanning Electron Microscopy (SEM). The geometric models were reconstructed based on computer tomography images of an undamaged molar followed by geometrical procedures of inducing the inlay and onlay reconstructions. The two functional models were then simulated for different orientations of external force and different material properties, according to the considered adhesives and ceramics. The Scanning Electron Microscopy (SEM) was conducted on 30 extracted teeth, divided into three groups according to the adhesive cement type. Both FEM simulation and SEM investigations reveal very good mechanical behavior of the adhesive-dental structure and adhesive-ceramic interfaces for inlay and onlay reconstructions. All results lead to the conclusion that a physiological mastication force applied, regardless of direction, cannot produce a mechanical failure of either inlay or onlay reconstructions. The adhesive bond between the restorations and the dental structure can stabilize the ceramic restorations, resulting in a higher strength to the action of external forces. Full article
(This article belongs to the Special Issue Biomaterials Performance in Clinical Cases and Failure Analysis of Implants)
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14 pages, 2183 KiB  
Article
Influence of the Printing Angle and Load Direction on Flexure Strength in 3D Printed Materials for Provisional Dental Restorations
by Paula Derban, Romeo Negrea, Mihai Rominu and Liviu Marsavina
Materials 2021, 14(12), 3376; https://doi.org/10.3390/ma14123376 - 18 Jun 2021
Cited by 25 | Viewed by 2411
Abstract
The CAD/CAM techniques, especially additive manufacturing such as 3D printing, constitute an ever-growing part of obtaining different dental appliances and restorations. Of these, provisional restorations are of frequent use in daily dental practice and are the object of this study. Masticatory and parafunctional [...] Read more.
The CAD/CAM techniques, especially additive manufacturing such as 3D printing, constitute an ever-growing part of obtaining different dental appliances and restorations. Of these, provisional restorations are of frequent use in daily dental practice and are the object of this study. Masticatory and parafunctional forces determine flexure on these prostheses. This study investigates the influence of the printing angle and loading direction of the applied force on the flexure strength of two commercially available printable resins—Detax Freeprint Temp and Nextdent MFH Vertex dental. Ten rectangular beam specimens printed at the angle of 0, 45 and 90 degrees were fabricated of each of these materials, with an addition of 10 at 0 degrees for the investigation of the load direction. Three-point bending tests were performed in a universal testing machine. Flexure strength, strain at break and Young’s modulus were determined and a statistical analysis was performed on the obtained data. According to the statistical analysis, the flexural strength has a significance dependence with respect to degrees of orientation, for both investigated materials. Full article
(This article belongs to the Special Issue Biomaterials Performance in Clinical Cases and Failure Analysis of Implants)
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20 pages, 10035 KiB  
Article
Comparative Assessment of In Vitro and In Vivo Biodegradation of Mg-1Ca Magnesium Alloys for Orthopedic Applications
by Iulian Antoniac, Răzvan Adam, Ana Biță, Marian Miculescu, Octavian Trante, Ionuț Mircea Petrescu and Mark Pogărășteanu
Materials 2021, 14(1), 84; https://doi.org/10.3390/ma14010084 - 26 Dec 2020
Cited by 36 | Viewed by 2633
Abstract
Use of magnesium implants is a new trend in orthopedic research because it has several important properties that recommend it as an excellent resorbable biomaterial for implants. In this study, the corrosion rate and behavior of magnesium alloys during the biodegradation process were [...] Read more.
Use of magnesium implants is a new trend in orthopedic research because it has several important properties that recommend it as an excellent resorbable biomaterial for implants. In this study, the corrosion rate and behavior of magnesium alloys during the biodegradation process were determined by in vitro assays, evolution of hydrogen release, and weight loss, and further by in vivo assays (implantation in rabbits’ bone and muscle tissue). In these tests, we also used imaging assessments and histological examination of different tissue types near explants. In our study, we analyzed the Mg-1Ca alloy and all the hypotheses regarding the toxic effects found in in vitro studies from the literature and those from this in vitro study were rejected by the data obtained by the in vivo study. Thus, the Mg-1Ca alloy represents a promising solution for orthopedic surgery at the present time, being able to find applicability in the small bones: hand or foot. Full article
(This article belongs to the Special Issue Biomaterials Performance in Clinical Cases and Failure Analysis of Implants)
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12 pages, 1362 KiB  
Article
Geometric Analysis of Type B Aortic Dissections Shows Aortic Remodeling After Intervention Using Multilayer Stents
by Victor S. Costache, Jorn P. Meekel, Andreea Costache, Tatiana Melnic, Crina Solomon, Anca M. Chitic, Cristian Bucurenciu, Horatiu Moldovan, Iulian Antoniac, Gabriela Candea and Kak K. Yeung
Materials 2020, 13(10), 2274; https://doi.org/10.3390/ma13102274 - 15 May 2020
Cited by 8 | Viewed by 2229
Abstract
Recently, multilayer stents for type B aortic dissections (TBAD) have been proposed to decrease false lumen flow, increase and streamline true lumen flow, and retain branch vessel patency. We aimed to provide a protocol with standardized techniques to investigate aortic remodeling of TBAD [...] Read more.
Recently, multilayer stents for type B aortic dissections (TBAD) have been proposed to decrease false lumen flow, increase and streamline true lumen flow, and retain branch vessel patency. We aimed to provide a protocol with standardized techniques to investigate aortic remodeling of TBAD by multilayer flow modulators (MFM) in static geometric and hemodynamic analyses. Combining existing literature and new insights, a standardized protocol was designed. Using pre- and postoperative CT scans, geometric models were constructed, lumen dimensions were calculated, computational fluid dynamics (CFD) models were composed, and velocity and pressures were calculated. Sixteen TBAD cases treated with MFM were included for analysis. For each case, aortic remodeling was analyzed using post-processing medical imaging software. After 3D models were created, geometrical anatomical measurements were performed, and meshes for finite element analysis were generated. MFM cases were compared pre- and postoperatively; true lumen volumes increased (p < 0.001), false lumen volumes decreased (p = 0.001), true lumen diameter at the plane of maximum compression (PMC) increased (p < 0.001), and false lumen index decreased (p = 0.008). True lumen flow was streamlined, and the overall fluid velocity and pressures decreased (p < 0.001 and p = 0.006, respectively). This protocol provided a standardized method to evaluate the effects of MFM treatments in TBAD on geometric analyses, PMC, and CFD outcomes. Full article
(This article belongs to the Special Issue Biomaterials Performance in Clinical Cases and Failure Analysis of Implants)
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20 pages, 9620 KiB  
Article
Novel Hybrid Composites Based on PVA/SeTiO2 Nanoparticles and Natural Hydroxyapatite for Orthopedic Applications: Correlations between Structural, Morphological and Biocompatibility Properties
by Simona Cavalu, Luminita Fritea, Marcel Brocks, Katia Barbaro, Gelu Murvai, Traian Octavian Costea, Iulian Antoniac, Claudio Verona, Martina Romani, Alessandro Latini, Romano Zilli and Julietta V. Rau
Materials 2020, 13(9), 2077; https://doi.org/10.3390/ma13092077 - 1 May 2020
Cited by 33 | Viewed by 3163
Abstract
The properties of poly(vinyl alcohol) (PVA)-based composites recommend this material as a good candidate for the replacement of damaged cartilage, subchondral bone, meniscus, humeral joint and other orthopedic applications. The manufacturing process can be manipulated to generate the desired biomechanical properties. However, the [...] Read more.
The properties of poly(vinyl alcohol) (PVA)-based composites recommend this material as a good candidate for the replacement of damaged cartilage, subchondral bone, meniscus, humeral joint and other orthopedic applications. The manufacturing process can be manipulated to generate the desired biomechanical properties. However, the main shortcomings of PVA hydrogels are related to poor strength and bioactivity. To overcome this situation, reinforcing elements are added to the PVA matrix. The aim of our work was to develop and characterize a novel composition based on PVA reinforced with Se-doped TiO2 nanoparticles and natural hydroxyapatite (HA), for possible orthopedic applications. The PVA/Se-doped TiO2 composites with and without HA were structurally investigated by FTIR and XRD, in order to confirm the incorporation of the inorganic phase in the polymeric structure, and by SEM and XRF, to evidence the ultrastructural details and dispersion of nanoparticles in the PVA matrix. Both the mechanical and structural properties of the composites demonstrated a synergic reinforcing effect of HA and Se-doped TiO2 nanoparticles. Moreover, the tailorable properties of the composites were proved by the viability and differentiation potential of the bone marrow mesenchymal stem cells (BMMSC) to osteogenic, chondrogenic and adipogenic lineages. The novel hybrid PVA composites show suitable structural, mechanical and biological features to be considered as a promising biomaterial for articular cartilage and subchondral bone repair. Full article
(This article belongs to the Special Issue Biomaterials Performance in Clinical Cases and Failure Analysis of Implants)
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