Targeting the Gut/Brain Axis in Inflammatory Disorders
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".
Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 8840
Special Issue Editors
Interests: enteric glia, colitis, gut-brain axis, neuroinflammation
Special Issues, Collections and Topics in MDPI journals
Interests: blood–brain barrier; neuroinflammation; neurodegeneration; astrocytes, microglia
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent years, new findings have revealed that intestinal neural circuits within the enteric nervous system are endowed with molecular mechanisms that monitor and integrate luminal factors, such as diet and microbiota, to regulate most aspects of intestinal physiology, including motility and neurotransmission. Their dysregulation occurs in intestinal diseases with an active inflammatory component, such as inflammatory bowel disease (IBD), diseases that involve neuroplasticity, such as irritable bowel disease (IBS), as well as extragastrointestinal disorders, such as Parkinson's disease and obesity. Changes in the enteric environment and neuronal function are, therefore, considered important in the development of gastrointestinal pathologies and gut–brain signaling disorders. The latter of these are preceded by alterations in the intestinal barrier integrity and enteric glia activation that reverberate to the central nervous system via the gut–brain axis, mirroring similar alterations in the blood–brain barrier properties and central glial activation.
This Special Issue, edited by Dr. Luisa Seguella and Dr. Simona Spampinato, will focus on the current concepts regarding mechanisms by which the brain may perceive intestinal environment changes, how enteric and central neural circuits are influenced by intestinal luminal factors, and the functional roles of the gut–brain axis in the neuronal pathophysiology of GI and extra-GI diseases. Drugs or therapies that specifically target any aspect of this complex scenario are increasingly attractive, and we encourage colleagues within the field of neuroscience to join this Special Issue to highlight the most innovative and effective therapeutic approaches to treat gut–brain axis disorders.
Dr. Luisa Seguella
Dr. Simona Federica Spampinato
Guest Editors
Manuscript Submission Information
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Keywords
- gut–brain disorders
- neuroplasticity
- pharmacology
- neuroinflammation
- reactive gliosis
- blood–brain barrier
