Frontiers in Vascular Biology-Volume II

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (25 December 2022) | Viewed by 1747

Special Issue Editors


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Guest Editor
Department of Microbiology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
Interests: vascular biology; diabetes; oxidative stress; inflammation; autophagy; atherosclerosis; artificial vessels; mitochondria
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul 156-755, Republic of Korea
Interests: insulin signaling; diabetes; cardiovascular disease; endothelium; heart
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The first volume of Special Issue has been successfully completed. We are planning to publish a second volume, so we invite you to publish your research.

The main goal of this Special Issue is to share the latest knowledge in the field of vascular biology, and to share strategies, prospects and expectations for the treatment of vascular diseases.

The vascular endothelium is composed of a monolayer of cells and is an important organ for controlling vascular functions. The endothelium has multiple functions, including regulation of vascular growth and remodeling, modulation of immune and thrombotic responses, and control of homeostasis and angiogenesis through interactions between the vessel wall and immune cells. Impairment of endothelial function is implicated in most cardiovascular diseases, including diabetes, atherosclerosis, coronary artery disease, and hypertension. For this Special Issue, we invite investigators to contribute original research articles and review articles as well as clinical studies that will stimulate efforts contributing to enhancing our understanding of vascular biology.

The first volume of this Special Issue was a great success. Now, we invite you to publish in the second volume (https://www.mdpi.com/journal/life/special_issues/Vascular_Biology).

Prof. Dr. Yongseek Park
Prof. Dr. Jaetaek Kim
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular diseases
  • vascular dysfunction
  • thrombosis
  • angiogenesis

Published Papers (1 paper)

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Research

11 pages, 1588 KiB  
Article
Challenges and Pitfalls in CT-Angiography Evaluation of Carotid Bulb Stenosis: Is It Time for a Reappraisal?
by Antonio Pierro, Pietro Modugno, Roberto Iezzi and Savino Cilla
Life 2022, 12(11), 1678; https://doi.org/10.3390/life12111678 - 22 Oct 2022
Viewed by 1440
Abstract
We aimed to perform an anatomical evaluation of the carotid bulb using CT-angiography, implement a new reliable index for carotid stenosis quantification and to assess the accuracy of relationship between NASCET and ECST methods in a large adult population. The cross-sectional areas of [...] Read more.
We aimed to perform an anatomical evaluation of the carotid bulb using CT-angiography, implement a new reliable index for carotid stenosis quantification and to assess the accuracy of relationship between NASCET and ECST methods in a large adult population. The cross-sectional areas of the healthy carotid at five levels were measured by two experienced radiologists. A regression analysis was performed in order to quantify the relationship between the areas of the carotid bulb at different carotid bulbar level. A new index (Regression indeX, RegX) for carotid stenosis quantification was proposed. Five different stenoses with different grade in three bulbar locations were simulated for all patients for a total of 1365 stenoses and were used for a direct comparison of the RegX, NASCET, and ECST methods. The results of this study demonstrated that the RegX index provided a consistent and accurate measure of carotid stenosis through the application of the ECST method, avoiding the limitations of NASCET method. Furthermore, our results strongly depart from the consolidated relationships between NASCET and ECST values used in clinical practice and reported in extensive medical literature. In particular, we highlighted that a major misdiagnosis in patient selection for CEA could be introduced because of the large underestimation of real stenosis degree provided by the NASCET method. A reappraisal of carotid stenosis patients’ work-up is evoked by the effectiveness of state-of-the-art noninvasive contemporary carotid imaging. Full article
(This article belongs to the Special Issue Frontiers in Vascular Biology-Volume II)
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