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Special Issue "The Materno-Fetal Outcome of Pregnancies in Chronic Diseases"

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A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Epidemiology".

Deadline for manuscript submissions: closed (25 December 2022) | Viewed by 5116

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Special Issue Editors

Dr. Anca Emanuela Mușetescu

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Guest Editor

Department of Rheumatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Interests: rheumatic diseases; musculoskeletal ultrasound; capillaroscopy

Dr. Anca Pantea Stoian

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Guest Editor

Department of Diabetes, Nutrition and Metabolic Diseases, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
Interests: diabetes; nutrition; metabolic diseases; chronic kidney disease
Special Issues, Collections and Topics in MDPI journals

Dr. Anca Bobircă

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Guest Editor

Department of Rheumatology and Internal Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
Interests: autoimmune and inflammatory rheumatic diseases; pregnancy in rheumatic diseases; inheritance of rheumatic diseases

Special Issue Information

Dear Colleagues,

At their reproductive age, patients with chronic conditions have a higher risk of pregnancy complications, both maternal and fetal. Chronic illnesses and risk factors have been associated over time with maternal complications, gestational diabetes and pre-eclampsia (the latter being the most prevalent). Nevertheless, the extent of chronic diseases is vast, ranging from cardiovascular, endocrine, nutritional, neurologic, rheumatic, hematologic, nephrology, to ophthalmologic and even dermatologic conditions. The study of maternal and fetal outcomes of pregnancy in chronic diseases is of great importance in order to help our patients plan a pregnancy, better define medication compatibility, to have a favorable maternal and fetal outcome and also better understand the long-term effects on children. Familial aggregation represents the Achilles’ heel among patients with chronic diseases who plan a pregnancy, due to the fear of transmission. The aim of this Special Issue is to better understand the complex situations that may arise during pregnancy in patients with chronic illnesses, to establish the most prevalent adverse pregnancy events and the transmissibility of certain diseases. We are delighted to invite you to submit your papers covering your clinical experience, as well as the current knowledge and recommendations in this domain.

Dr. Anca Emanuela Mușetescu
Dr. Anca Pantea Stoian
Dr. Anca Bobircă
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

pregnancy in chronic diseases
pregnancy outcome
children follow- up
familial aggregation

Published Papers (3 papers)

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13 pages, 307 KiB

Open AccessArticle

Outcomes of Prospectively Followed Pregnancies in Rheumatoid Arthritis: A Multicenter Study from Romania

Anca Bobircă

Anca Angela Simionescu

Anca Emanuela Mușetescu

and

Life 2023, 13(2), 359; https://doi.org/10.3390/life13020359 - 28 Jan 2023

Cited by 1 | Viewed by 968

Abstract

Women with rheumatoid arthritis (RA) may carry an increased risk of adverse pregnancy outcomes (APO). The aims of this study were to compare pregnancy outcomes in RA patients as compared to the general obstetric population (GOP) and to identify a risk profile in RA. A case-control study was conducted on 82 prospectively followed pregnancies in RA and 299 pregnancies from the GOP. The mean age at conception was 31.50 ± 4.5 years, with a mean disease duration of 8.96 ± 6.3 years. The frequency of APO in RA patients was 41.5%, 18.3% experienced spontaneous abortions, 11.0% underwent preterm deliveries, 7.3% had small for gestational age infants, 4.9% experienced intrauterine growth restriction, 1.2% experienced stillbirth, and 1.2% suffered from eclampsia. The risk of APO was correlated with a maternal age higher than 35 years (p = 0.028, OR = 5.59). The rate of planned pregnancies was 76.8%, and the subfertility rate was 4.9%. Disease activity improved every trimester, and approximately 20% experienced an improvement in the second trimester. Planned pregnancies and corticosteroids use (≤10 mg daily) were protective factors for APO in RA pregnancies (p < 0.001, OR = 0.12, p = 0.016, OR = 0.19, respectively). There was no significant association between APO and disease activity or DMARDs used before and during pregnancy. Regarding the comparison between the RA group and the controls, RA mothers were significantly older (p = 0.001), had shorter pregnancies (p < 0.001), and had neonates with a lower birth weight (p < 0.001). Full article

(This article belongs to the Special Issue The Materno-Fetal Outcome of Pregnancies in Chronic Diseases)

10 pages, 955 KiB

Open AccessArticle

Does a Single Exposure to General Anesthesia Have a Cumulative Effect on the Developing Brain after Mild Perinatal Asphyxia?

Irina-Mihaela Matache

and

Life 2022, 12(10), 1568; https://doi.org/10.3390/life12101568 - 09 Oct 2022

Cited by 1 | Viewed by 1288

Abstract

Background: General anesthesia (GA) in pediatric patients represents a clinical routine. Factors such as increased birth age and maternal chronic conditions cause more infants to experience hypoxic-ischemic encephalopathy, an additional risk for anesthesia. Aim: This study evaluates the effect of one sevoflurane-induced GA episode on the immature brain previously exposed to perinatal asphyxia (PA). Methods: Postnatal day 6 (PND6) Wistar rats were exposed to a 90-min episode of normoxia/PA and at PND15 to a 120-min episode of normoxia/GA. Four groups were analyzed: Control (C), PA, GA, and PA-GA. Post-exposures, fifteen pups/group were sacrificed and the hippocampi were isolated to assess S-100B and IL-1B protein levels, using ELISA. At maturity, the behavior was assessed by: forced swimming test (FST), and novel object recognition test. Results: Hippocampal S-100B level was increased in PA, GA, and PA-GA groups, while IL-1B was increased in PA, but decreased in PA-GA. The immobility time was increased in PA and PA-GA, in FST. Conclusions: Both PA and GA contribute to glial activation, however with no cumulative effect. Moreover, PA reduces the rats’ mobility, irrespective of GA exposure, while memory evaluated by the novel object recognition test was not influenced. Full article

(This article belongs to the Special Issue The Materno-Fetal Outcome of Pregnancies in Chronic Diseases)

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Open AccessReview

Pregnancy in Patients with Inflammatory Bowel Diseases—A Literature Review

Raluca Roxana Grigorescu

Ioana Alexandra Husar-Sburlan

and

Madalina Marieta Florescu

Life 2023, 13(2), 475; https://doi.org/10.3390/life13020475 - 09 Feb 2023

Cited by 1 | Viewed by 2384

Abstract

In recent years, we have faced an increasing incidence of inflammatory bowel disease (IBD), especially among young people, affecting them during their reproductive years. The paucity of data and reduced knowledge regarding the evolution of the disease during pregnancy and the adverse effects of the therapy on the mother and infant increase voluntary childlessness in this group of patients. Depending on the type of IBD, severity and surgical or medical management, this can negatively affect the pregnancy. C-sections and the risk of low-birth-weight babies are higher in women with IBD, independent of active/inactive disease, while preterm birth, stillbirth and miscarriage are associated with disease activity. In the last period, medicinal therapy has evolved, and new molecules have been developed for better control of the lesions, but the effect on pregnancy and breastfeeding is still controversial. We conducted this review by studying the literature and recent research in order to have a better image of the practical management of IBD during pregnancy. Full article

(This article belongs to the Special Issue The Materno-Fetal Outcome of Pregnancies in Chronic Diseases)

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