Cancer Cell Metastasis: In Vitro and In Vivo Approaches
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".
Deadline for manuscript submissions: closed (15 October 2022) | Viewed by 2414
Special Issue Editor
Interests: cancer cell metastasis; in vitro models; adhesion; extracellular matrix; actin cytoskeleton; invasion
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In most cases, cancer-related mortality is attributed to the effects and complications of cancer cell metastasis and not the primary tumor itself. Metastasis is a complex process during which cells initially dissociate from the original tumor, then migrate and invade through the extracellular matrix and surrounding tissues. Subsequently, they disseminate through the circulation to distant sites in the body, where they form metastatic tumors. Although extensive research has been conducted in this field, several questions remain unanswered. Taking advantage of new developments in cell culture systems and models, as well as animal models, efforts have been undertaken to mimic the metastatic process in vitro and in vivo in order to improve its study, understand it and, ultimately, reverse it. This Special Issue aims to present these advances in cancer cell metastasis-related research involving both in vitro and in vivo approaches and models, providing a more thorough understanding of cancer cell metastasis and cellular and molecular events and mechanisms defining it. The studies may involve culture models and assays developed in two or three dimensions (3D) in any type of cancer cell lines, animal models, xenografts, and any related molecular signaling pathways that regulate cancer metastasis, cell adhesion, migration, invasion and proliferation.
Dr. Vasiliki Gkretsi
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer cell metastasis
- tumor spheroids
- 3D culture models
- in vitro experimentation
- actin cytoskeleton
- cell invasion
- extracellular matrix
- cell adhesion
- animal cancer models
- in vivo
- xenograft models
