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Life
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Vitamin D in Autoimmune and Infectious Diseases
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Vitamin D in Autoimmune and Infectious Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2189

Special Issue Editors

Dr. Panagiotis Athanassiou

E-Mail Website
Guest Editor
Department of Rheumatology, St. Paul’s Hospital, Thessaloniki, Greece
Interests: rheumatoid arthritis; tumour necrosis factor; fatty acids; treatment
Special Issues, Collections and Topics in MDPI journals
Dr. Ifigenia Kostoglou-Athanassiou

E-Mail Website
Guest Editor
Asclepeion Hospital, Athens, Greece
Interests: rheumatoid arthritis; diabetes mellitus; oncology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Yehuda Shoenfeld

E-Mail Website
Guest Editor
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Reichman University, Herzelya 4610101, Israel
Interests: autoimmune diseases; clinical immunology; systemic lupus erythematosus; rheumatology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Vitamin D is a hormone with multiple actions and potent immunomodulatory properties, as it may enhance the innate immune response and may modulate the adaptive immune response. Vitamin D deficiency has been observed in various autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease, and systemic sclerosis. Vitamin D may be a useful addition in the therapeutic management of multiple sclerosis as it may modulate the autoimmune process involved in the pathogenesis of the disease. Vitamin D administration may also be useful in the management of systemic lupus erythematosus. Vitamin D may enhance the innate immune response and may be helpful in the fight against infectious diseases. Vitamin D deficiency has been related to the severity of SARS-CoV-2 infection, and its administration may be a useful addition in the armamentarium against this disease.

In this Special Issue, all articles related to vitamin D, its immunomodulatory properties, and its relationship with autoimmune and infectious diseases are welcome.

Dr. Panagiotis Athanassiou
Dr. Ifigenia Kostoglou-Athanassiou
Prof. Dr. Yehuda Shoenfeld
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vitamin D
  • autoimmunity
  • rheumatoid arthritis
  • systemic lupus erythematosus
  • systemic sclerosis
  • infectious agents
  • COVID-19
  • SARS-CoV-2

Published Papers (2 papers)

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Research

12 pages, 460 KiB  
Article
Retrospective Analysis of Vitamin D Deficiency in an Adult Population of Arad County, Western Romania (2019–2022)
by Daniela Teodora Marti, Alexandru Nesiu, Cornel Balta, Tudor Rares Olariu, Alin Gabriel Mihu, Anca Hermenean and Daniela Adriana Oatis
Life 2024, 14(2), 274; https://doi.org/10.3390/life14020274 - 18 Feb 2024
Viewed by 945
Abstract
Vitamin D, a steroid hormone synthesized primarily in the skin upon exposure to ultraviolet light, is widely deficient across global populations. This study aimed to fill the data gap in Western Romania by measuring 25-hydroxy-vitamin D levels in a cohort of 7141 from [...] Read more.
Vitamin D, a steroid hormone synthesized primarily in the skin upon exposure to ultraviolet light, is widely deficient across global populations. This study aimed to fill the data gap in Western Romania by measuring 25-hydroxy-vitamin D levels in a cohort of 7141 from Arad County. It was observed that women, younger adults (18–29 years), and older adults (70–79 years) had notably lower vitamin D levels compared to the average population. Additionally, there was a rise in vitamin D levels over the four-year span of 2018–2022, coinciding with the COVID-19 pandemic. Our research provides fresh data on those most susceptible to vitamin D deficiency and lays the groundwork for educational campaigns on vitamin D supplementation benefits. Full article
(This article belongs to the Special Issue Vitamin D in Autoimmune and Infectious Diseases)
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15 pages, 1709 KiB  
Article
Vitamin D Levels as a Marker of Severe SARS-CoV-2 Infection
by Lambros Athanassiou, Ifigenia Kostoglou-Athanassiou, Sofia Nikolakopoulou, Alexandra Konstantinou, Olga Mascha, Evangelos Siarkos, Charilaos Samaras, Panagiotis Athanassiou and Yehuda Shoenfeld
Life 2024, 14(2), 210; https://doi.org/10.3390/life14020210 - 31 Jan 2024
Viewed by 956
Abstract
The SARS-CoV-2 virus may cause severe infection, which is associated with diverse clinical manifestations. Vitamin D has immunomodulating properties and may enhance the body’s defense system against invading pathogenic organisms. The aim was to assess 25(OH)D3 levels in patients hospitalized for severe [...] Read more.
The SARS-CoV-2 virus may cause severe infection, which is associated with diverse clinical manifestations. Vitamin D has immunomodulating properties and may enhance the body’s defense system against invading pathogenic organisms. The aim was to assess 25(OH)D3 levels in patients hospitalized for severe infection from the SARS-CoV-2 virus and explore the relationship between 25(OH)D3 and outcomes. In a group of 88 patients hospitalized for severe infection from the SARS-CoV-2 virus and a control group matched for age and sex, the levels of 25(OH)D3 were analyzed. Levels of 25(OH)D3 were 17.36 ± 8.80 ng/mL (mean ± SD) compared with 24.34 ± 10.34 ng/mL in patients with severe SARS-CoV-2 infection and the control group, respectively, p < 0.001 (Student’s t-test). 25(OH)D3 levels were significantly related to outcomes, i.e., survival as opposed to non-survival, as more patients with 25(OH)D3 deficiency (0–10 ng/mL) and insufficiency (10–20 ng/mL) had a fatal outcome as compared with those with vitamin D sufficiency (p < 0.001, chi-square test, p < 0.001, Fisher’s exact test). Levels of 25(OH)D3 were inversely related to C-reactive protein (CRP), ferritin, d-dimer, and fibrinogen levels (p < 0.001, linear regression analysis, beta coefficient of variation, −0.176, −0.160, −0.178, and −0.158, respectively). Vitamin D deficiency observed in severe SARS-CoV-2 infection was related to disease outcomes. Full article
(This article belongs to the Special Issue Vitamin D in Autoimmune and Infectious Diseases)
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