Prostate Cancer: 3rd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 30 October 2024 | Viewed by 1580

Special Issue Editors


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Guest Editor
1. Department of Zootechnics, School of Sciences and Technology, University of Évora, Évora, Portugal
2. Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Vila Real, Portugal
Interests: veterinary medicine; experimental animal models; anti-inflammatory drugs; physical exercise; tumor angiogenesis; lymphangiogenesis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5001-801 Vila Real, Portugall
2. Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), 5001-801 Vila Real, Portugal
Interests: animal models of human diseases; translational research on breast, liver, prostate, urinary bladder, and colorectal cancers; pharmacology; therapeutics; in vitro studies; in vivo studies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are grateful to the researchers who contributed to the first and second volume of this issue:

Prostate Cancer: https://www.mdpi.com/journal/life/special_issues/pros_can

Prostate Cancer: 2nd Edition: https://www.mdpi.com/journal/life/special_issues/Z5E9V92OYG

We are pleased to announce the upcoming publication of of our Special Issue, entitled “Prostate Cancer: 3rd Edition".

The prostate is the largest accessory gland of the male reproductive tract. Together with seminal vesicles and bulbourethral glands, the prostate is responsible for the production of an alkaline fluid that forms part of the seminal fluid. The prostates of men over 40 years of age are commonly affected by several pathologies, such as benign prostate hyperplasia and cancer.

Prostate cancer is one of the most frequently occurring cancers among the male population worldwide. According to the World Health Organization (WHO), the year 2020 saw prostate cancer affect approximately 1.41 million men and be responsible for the deaths of 375,304 of them. Prostate cancer development is associated with several risk factors including older age, African ancestry, a family history of the disease, an increased body mass index, and obesity. The risk of prostate cancer development may be reduced through the consumption of a healthy diet full of fruits and vegetables, physical exercise, and maintenance of a healthy weight.

Despite several approaches being available for prostate cancer treatment, the number of prostate cancer deaths is continuously increasing, which emphasizes the need to search for new methods for precocious diagnosis and more effective treatment. Animal models including rodents have greatly contributed to the study of biopathology and the prevention and treatment of prostate cancer.

This Special Issue, entitled “Prostate Cancer: 3rd Edition”, aims to publish original research works and reviews concerning the diagnosis, treatment, and prognosis of prostate cancer, highlighting new advances in this field.

Dr. Ana Faustino
Dr. Paula A. Oliveira
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • incidence
  • mortality
  • diagnosis
  • histopathology
  • imaging
  • treatment
  • prognosis
  • case report
  • animals
  • humans
  • modelling

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Published Papers (1 paper)

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Review

18 pages, 8612 KiB  
Review
The Cavernous Nerve Injury Rat Model: A Pictorial Essay on Post-Radical Prostatectomy Erectile Dysfunction Research
by Silviu Constantin Latcu, Dorin Novacescu, Victor-Bogdan Buciu, Cristina-Stefania Dumitru, Raluca Amalia Ceausu, Marius Raica, Talida Georgiana Cut, Razvan Ilina, Daniel Claudiu Malita, Cristi Tarta and Alin Adrian Cumpanas
Life 2023, 13(12), 2337; https://doi.org/10.3390/life13122337 - 13 Dec 2023
Cited by 1 | Viewed by 1197
Abstract
Understanding and addressing post-radical prostatectomy (RP) erectile dysfunction (ED) is of paramount importance for clinicians. Cavernous nerve (CN) injury rat model studies have provided consistently promising experimental data regarding regaining erectile function (EF) after nerve damage-induced ED. However, these findings have failed to [...] Read more.
Understanding and addressing post-radical prostatectomy (RP) erectile dysfunction (ED) is of paramount importance for clinicians. Cavernous nerve (CN) injury rat model studies have provided consistently promising experimental data regarding regaining erectile function (EF) after nerve damage-induced ED. However, these findings have failed to translate efficiently into clinical practice, with post-RP ED therapeutic management remaining cumbersome and enigmatic. This disparity highlights the need for further standardization and optimization of the elaborate surgical preparation protocols and multifaceted reporting parameters involved in reliable CN injury rat model experimentation. Even so, despite its technical complexity, this animal model remains instrumental in exploring the functional implications of RP, i.e., surgical lesions of the neurovascular bundles (NVBs). Herein, besides cavernous nerve (CN) dissection, injury, and electrostimulation, multiple pressure measurements, i.e., mean arterial pressure (MAP) and intra-cavernosal pressure (ICP), must also be achieved. A transverse cervical incision allows for carotid artery cannulation and MAP measurements. Conversely, ICP measurements entail circumcising the penis, exposing the ischiocavernous muscle, and inserting a needle into the corporal body. Finally, using an abdominal incision, the prostate is revealed, and the major pelvic ganglia (MPG) and CNs are dissected bilaterally. Specific surgical techniques are used to induce CN injuries. Herein, we provide a narrative and illustrative overview regarding these complex experimental procedures and their particular requirements, reflecting on current evidence and future research perspectives. Full article
(This article belongs to the Special Issue Prostate Cancer: 3rd Edition)
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