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Life
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Olfactory and Gustatory Dysfunctions
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Olfactory and Gustatory Dysfunctions

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1760

Special Issue Editors

Dr. Maniaci Antonino

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Guest Editor
Faculty of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy
Interests: ENT; imaging; head and neck surgery; oral cancer; laryngeal cancer; pathology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jerome Rene Lechien

E-Mail Website
Guest Editor
1. Department of Anatomy and Experimental Oncology, Mons School of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium
2. Department of Otolaryngology-Head Neck Surgery, Elsan Polyclinic of Poitiers, Poitiers, France
Interests: otolaryngology; oral cancer oncology
Special Issues, Collections and Topics in MDPI journals
Dr. Luigi Angelo Vaira

E-Mail Website
Guest Editor
1. Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy
2. Biomedical Science Department, PhD School of Biomedical Science, University of Sassari, 07100 Sassari, Italy
Interests: oral and maxillofacial surgery; plastic surgery; otolaryngology
Special Issues, Collections and Topics in MDPI journals
Dr. Luigi La Via

E-Mail Website
Guest Editor
Department of Anesthesiology and Intensive Care, AOU “Policlinico-San Marco”, 95123 Catania, Italy
Interests: cardiac arrest; echocardiography; post-resuscitation care; oxygen; airways; simulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue provides an in-depth overview of disorders related to the sense of smell and taste, delving into the mechanisms and causes of these dysfunctions, including genetic predisposition, trauma, infections, and neurodegenerative diseases. It underscores the importance of precise clinical evaluation and diagnosis, highlighting assessment methods such as subjective reports, psychophysical tests, and neuroimaging techniques.

Various treatment approaches and rehabilitation strategies for olfactory and gustatory dysfunctions are discussed, ranging from pharmacological interventions for specific causes—like decongestants or corticosteroids for sinusitis and zinc supplementation for taste dysfunctions resulting from zinc deficiency—to smell training and taste modification techniques. The Special Issue highlights the potential of emerging technologies in treating these sensory impairments. Developments in olfactory implants that stimulate the olfactory nerve directly are discussed, as are virtual reality-based rehabilitation programs that simulate sensory experiences to aid recovery. The Special Issue concludes by outlining future research directions, emphasizing the need for interdisciplinary collaborations and the integration of advanced technologies for personalized treatments based on individual characteristics and genetic profiles. This Special Issue aims to bolster the diagnosis, management, and overall well-being of individuals affected by these sensory impairments by broadening our understanding of this field.

Dr. Maniaci Antonino
Prof. Dr. Jerome Rene Lechien
Dr. Luigi Angelo Vaira
Dr. Luigi La Via
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • olfactory and gustatory dysfunctions
  • clinical evaluation and diagnosis
  • treatment approaches and rehabilitation strategies
  • emerging technologies in treatment

Published Papers (2 papers)

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Editorial

Jump to: Research

4 pages, 475 KiB  
Editorial
Taste and Smell Disorders: A Critical Look at Olfactory and Gustatory Dysfunction
by Antonino Maniaci, Jérome R. Lechien, Luigi Angelo Vaira and Luigi La Via
Life 2024, 14(3), 301; https://doi.org/10.3390/life14030301 - 26 Feb 2024
Viewed by 741
Abstract
In an era where modern medicine has made remarkable advances in managing diseases in the head and neck region, we present this Special Issue to provide a spotlight on the new research advances on olfactory and gustatory disorders [...] Full article
(This article belongs to the Special Issue Olfactory and Gustatory Dysfunctions)
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Research

Jump to: Editorial

12 pages, 613 KiB  
Article
The Bittersweet Symphony of COVID-19: Associations between TAS1Rs and TAS2R38 Genetic Variations and COVID-19 Symptoms
by Aurora Santin, Beatrice Spedicati, Alessandro Pecori, Giuseppe Giovanni Nardone, Maria Pina Concas, Gioia Piatti, Anna Menini, Giancarlo Tirelli, Paolo Boscolo-Rizzo and Giorgia Girotto
Life 2024, 14(2), 219; https://doi.org/10.3390/life14020219 - 03 Feb 2024
Viewed by 794
Abstract
The innate immune system is crucial in fighting SARS-CoV-2 infection, which is responsible for coronavirus disease 2019 (COVID-19). Therefore, deepening our understanding of the underlying immune response mechanisms is fundamental for the development of novel therapeutic strategies. The role of extra-oral bitter (TAS2Rs) [...] Read more.
The innate immune system is crucial in fighting SARS-CoV-2 infection, which is responsible for coronavirus disease 2019 (COVID-19). Therefore, deepening our understanding of the underlying immune response mechanisms is fundamental for the development of novel therapeutic strategies. The role of extra-oral bitter (TAS2Rs) and sweet (TAS1Rs) taste receptors in immune response regulation has yet to be fully understood. However, a few studies have investigated the association between taste receptor genes and COVID-19 symptom severity, with controversial results. Therefore, this study aims to deepen the relationship between COVID-19 symptom presence/severity and TAS1R and TAS2R38 (TAS2Rs member) genetic variations in a cohort of 196 COVID-19 patients. Statistical analyses detected significant associations between rs307355 of the TAS1R3 gene and the following COVID-19-related symptoms: chest pain and shortness of breath. Specifically, homozygous C/C patients are exposed to an increased risk of manifesting severe forms of chest pain (OR 8.11, 95% CI 2.26–51.99) and shortness of breath (OR 4.83, 95% CI 1.71–17.32) in comparison with T/C carriers. Finally, no significant associations between the TAS2R38 haplotype and the presence/severity of COVID-19 symptoms were detected. This study, taking advantage of a clinically and genetically characterised cohort of COVID-19 patients, revealed TAS1R3 gene involvement in determining COVID-19 symptom severity independently of TAS2R38 activity, thus providing novel insights into the role of TAS1Rs in regulating the immune response to viral infections. Full article
(This article belongs to the Special Issue Olfactory and Gustatory Dysfunctions)
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