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Life
Special Issues
Pathological Diagnosis of Gynecological and Fetal Diseases
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Pathological Diagnosis of Gynecological and Fetal Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1212

Special Issue Editors

Dr. Valerio Gaetano Vellone

E-Mail Website
Guest Editor
Department of Integrated Surgical and Diagnostic Sciences, University of Genoa Anatomic Pathology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy
Interests: gynecological; placental; fetal; pediatric pathology
Special Issues, Collections and Topics in MDPI journals
Dr. Michele Paudice

E-Mail Website
Guest Editor
Department of Integrated Surgical and Diagnostic Sciences, University of Genoa Anatomic Pathology University Unit, IRCCS Ospedale Policlinico San Martina, Genoa, Italy
Interests: gynecological; placental; fetal pathology

Special Issue Information

Dear Colleagues,

We warmly welcome researchers, pathologists, and medical professionals to contribute to a Special Issue of Life on gynecological and fetal pathology. The purpose of this Special Issue is to provide a platform for disseminating the latest research, advances, and knowledge in the field of gynecological and fetal pathology. We welcome the submission of original research articles and reviews examining various aspects of gynecological and fetal pathologies, including diagnostic challenges, prognostic markers, new technologies, and therapeutic interventions.

Gynecological and fetal pathologies include a wide range of diseases that have a significant impact on the health and well-being of women and fetuses. The purpose of this Special Issue is to highlight the latest advances in the understanding, diagnosis, and treatment of gynecological and fetal diseases and to promote collaboration and knowledge sharing among professionals in the field. We welcome contributions on the following topics:

Gynecological malignancies:

Advances in the diagnosis, classification, and molecular profiling of gynecologic cancers such as cervical, endometrial, ovarian, vulval, and vaginal cancers. Research investigating new prognostic markers, therapeutic targets, and individualized treatment strategies is particularly encouraged.

Pathology of the placenta:

Research focused on the histological evaluation of the placenta, its role in pregnancy complications, and its association with adverse fetal outcomes. Research into placental abnormalities such as placental insufficiency, placental abruption, and gestational trophoblastic disease to contribute to a better understanding of maternal and fetal health.

Fetal and neonatal pathologies:

Studies on histopathological examination of fetal and neonatal tissues to identify birth defects, genetic disorders, and perinatal infections. Research that explores the molecular basis of fetal disease and the correlation between histological findings and clinical outcomes is highly encouraged.

Diagnostic challenges and new technologies:

Articles on diagnostic challenges in gynecological and fetal pathology, including the interpretation of complex histopathological patterns, immunohistochemical and molecular studies, and integration of imaging techniques. Research into innovative technologies such as digital pathology, artificial intelligence, and next-generation sequencing is of great interest.

We invite researchers from various fields, including pathology, obstetrics and gynecology, oncology, genetics, and maternal and child medicine, to contribute valuable research to this Special Issue. Together, we can advance the understanding and treatment of gynecological and fetal diseases, ultimately improving the health of women and fetuses.

Dr. Valerio Gaetano Vellone
Dr. Michele Paudice
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gynecologic pathology
  • placental pathology
  • fetal pathology
  • ovarian cancer
  • endometrial cancer
  • cervical cancer
  • vulvar cancer
  • molecular pathology

Published Papers (1 paper)

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Research

11 pages, 575 KiB  
Article
How Old Is Too Old? Outcomes of Prolapse Native-Tissue Repair through Uterosacral Suspension in Octogenarians
by Marta Barba, Alice Cola, Desirèe De Vicari, Clarissa Costa, Silvia Volontè and Matteo Frigerio
Life 2024, 14(4), 433; https://doi.org/10.3390/life14040433 - 24 Mar 2024
Viewed by 616
Abstract
Introduction: Medical advancements are expected to lead to a substantial increase in the population of women aged 80 and older by 2050. Consequently, a significant number of individuals undergoing corrective prolapse surgery will fall into the elderly-patient category. The research indicates a notable [...] Read more.
Introduction: Medical advancements are expected to lead to a substantial increase in the population of women aged 80 and older by 2050. Consequently, a significant number of individuals undergoing corrective prolapse surgery will fall into the elderly-patient category. The research indicates a notable rise in complications associated with prolapse surgery in patients older than 80, irrespective of frailty and other risk factors. Despite these challenges, the vaginal approach has been identified as the safest surgical method for pelvic organ prolapse (POP) repair in the elderly population. For this reason, we aimed to investigate the efficacy, complication rate, and functional outcomes associated with vaginal hysterectomy and an apical suspension/high uterosacral ligaments suspension as a primary technique for prolapse repair, both within a cohort of elderly patients. Methods: We retrospectively analyzed patients who underwent transvaginal hysterectomy plus an apical suspension procedure for stage ≥ II and symptomatic genital prolapse between January 2006 and December 2013. Anatomical and functional outcomes were evaluated. The Patient Global Impression of Improvement (PGI-I) score was used to evaluate subjective satisfaction after surgery. Results: Sixty-five patients were included in the analysis. The median age was 81.3 years. All individuals exhibited an anterior compartment prolapse stage II or higher, and the majority also a central prolapse stage II or higher. Notably, all participants reported symptoms of vaginal bulging. Over half of the population (58.6%) complained of incomplete bladder emptying. The intervention for all participants involved a vaginal hysterectomy with an apical suspension. Sixty-three patients (96.9%) and forty-four patients (67.6%) underwent a simultaneous anterior or posterior repair, respectively. Long-term complications (>30 days from surgery) were observed during follow-up, with a median duration of 23 ± 20 months. Seven (10.7%) anatomical recurrences were recorded, five (7.69%) concerning the anterior compartment, one (1.5%) the central, and three (4.6%) the posterior. Nevertheless, none of them necessitated further surgical intervention due to symptoms. Significant anatomical improvements for the anterior, central, and posterior compartments were noticed, compared to preoperative assessment (p < 0.001 for Aa and Ba, p < 0.001 for Ap and Bp, and p < 0.001 for C). PGI-I values established that 100% of patients were satisfied (PGI-I ≥ 2), with a median score of 1.12. Consequently, objective and subjective cure rates were 89.5% and 100%, respectively. Conclusion: Vaginal hysterectomy combined with apical suspension, particularly high uterosacral ligaments suspension, is a safe and effective primary surgical approach, even in elderly patients. Full article
(This article belongs to the Special Issue Pathological Diagnosis of Gynecological and Fetal Diseases)
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