Kidney Transplantation: What’s Hot and What’s New
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 1085
Special Issue Editors
2. MD in the General, Emergency and Transplant Surgery Department, ASST dei Sette Laghi, via Guicciardini 9, 21100, Varese, Italy
Interests: kidney transplantation; robotic surgery; surgical oncology; immunology
Special Issues, Collections and Topics in MDPI journals
Interests: kidney transplantation; living donor nephrectomy; kidney-paired donation; incompatible living donor kidney transplantation; pancreas transplantation
Special Issue Information
Dear Colleagues,
The development of chronic kidney disease (CKD) and its progression to the terminal stage remains a significant cause of reduction in quality of life and premature mortality. CKD is an invalidating disease, and the standards of medical care involve aggressive monitoring for signs of disease progression and early referral to specialists for renal replacement therapy such as dialysis and kidney transplant. The number of kidney transplants performed has increased in many countries and their outcome has improved substantially in recent years, and tireless efforts have been made to reduce the waiting time for a kidney transplant and minimize the rate of graft loss, improving patient survival.
To increase the number of available kidneys and perform more transplantations, several strategies have been developed:
- Living donation promotion;
- Kidney exchange programs (KEP);
- Desensitization and AB0-incompatible protocols;
- The expansion of the donor's pool using extended criteria donors (ECDs), non-beating heart donors (NHBDs).
Moreover, nowadays, a deeper understanding of primary non-function (PNF) and delayed graft function (DGF) pathophysiology has been reached. These have led to improvements in the treatment of DGF, the prevention of PNF and the development of novel tools for a more objective, specific, and accurate assessment of the graft quality, such as pulsatile perfusion and graft regeneration and to shed light on regenerative medicine, which could play a pivotal role in the next future.
Finally, to optimize the results of kidney transplantation, significant enhancements have been introduced in immunosuppression through the use of more specific immunosuppressive strategies tailored both to graft and recipient features.
This Special Issue’s purpose is to explore the advances in kidney transplantation, focusing on interesting perspectives from both a clinical perspective and for the scientific community.
Dr. Giuseppe Ietto
Dr. Caterina Di Bella
Guest Editors
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Keywords
- kidney transplantation
- immunosuppression
- graft quality
- machine perfusion (MP)
- living donor kidney transplantation
