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Advances in Bioactive Compounds from Marine Fungi
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Advances in Bioactive Compounds from Marine Fungi

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungi in Agriculture and Biotechnology".

Deadline for manuscript submissions: 1 May 2024 | Viewed by 1699

Special Issue Editors

Dr. Chun-Lan Xie

E-Mail Website
Guest Editor
Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, Xiamen 361102, China
Interests: sea-derived fungus; metabolism; bioactive compounds
Prof. Dr. Xian-Wen Yang

E-Mail Website
Guest Editor
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China
Interests: marine drugs; deep-sea-derived microorganisms; fungi; secondary metabolites; bioactive compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Marine fungi are a promising source of biologically active and structurally diverse secondary metabolites and have provided drug leads for the treatment of numerous diseases. However, the potential of marine natural products (MNPs) as effective drugs for osteoporosis treatment is an understudied area. Additionally, very few osteoblast differentiation promotors have been isolated from natural sources. Therefore, the identification of bioactive small molecules that target osteoblasts represents a new direction in the search for antiosteoporosis candidate drugs. This Special Issue will collect manuscripts that highlight the antiosteoporosis activities or mechanism of new secondary metabolites from deep-sea-derived marine fungi. Original research articles, reviews, and communications are welcome.

Dr. Chun-Lan Xie
Prof. Dr. Xian-Wen Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine fungus
  • structural identification
  • bioactive natural product
  • bone formation
  • osteoporosis
  • molecular mechanisms

Published Papers (1 paper)

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Research

13 pages, 2442 KiB  
Article
Antibacterial Polyketides Isolated from the Marine-Derived Fungus Fusarium solani 8388
by Cankai Lin, Rongchun Huang, Juntao Liu, Hong Li, Liping Zhu, Xin Huang, Bo Ding, Lan Liu, Hongbo Huang and Yiwen Tao
J. Fungi 2023, 9(9), 875; https://doi.org/10.3390/jof9090875 - 24 Aug 2023
Viewed by 1313
Abstract
Seven new polyketides named fusarisolins F-K (1–6) and fusarin I (7) were isolated from the marine-derived fungus Fusarium solani 8388, together with the known anhydrojavanicin (8), 5-deoxybostry coidin (9), and scytalol A (10 [...] Read more.
Seven new polyketides named fusarisolins F-K (1–6) and fusarin I (7) were isolated from the marine-derived fungus Fusarium solani 8388, together with the known anhydrojavanicin (8), 5-deoxybostry coidin (9), and scytalol A (10). Their structures were established by comprehensive spectroscopic data analyses, and by comparison of the 1H and 13C NMR data with those reported in literature. Fusarisolin F (1) contained both a dichlorobenzene group and an ethylene oxide unit, which was rare in nature. In the bioassays, fusarisolin I (4), fusarisolin J (5), and 5-deoxybostry coidin (9) exhibited obvious antibacterial activities against methicillin-resistant Staphylococcus aureus n315 with MIC values of 3, 3, and 6 μg/mL, respectively. Fusarisolin H (3) and fusarisolin J (5) showed inhibitory effects against methicillin-resistant Staphylococcus aureus NCTC 10442 with the same MIC value of 6 μg/mL. With the exception of 5, all other compounds did not show or showed weak cytotoxicities against HeLa, A549, and KB cells; while fusarisolin J (5) demonstrated moderate cytotoxicities against the three human cancer cell lines with CC50 values between 9.21 and 14.02 μM. Full article
(This article belongs to the Special Issue Advances in Bioactive Compounds from Marine Fungi)
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