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Special Issue "Bioactive Compounds from the Deep-Sea-Derived Microorganisms 2nd Edition"

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Dear Colleagues,

Given the success of Volume I of this Special Issue, we are pleased to announce the launch of Volume II.

The first volume is available here: Bioactive Compounds from the Deep-Sea-Derived Microorganisms.

It is well-known that microorganisms are a source of a vast array of natural products. Unlike their terrestrial counterparts, marine microorganisms—especially those derived from the deep sea—live in extreme conditions (high pressure, high salinity, low oxygen, low/no light, etc.). Therefore, they can produce unique chemical structures with a broad spectrum of biological activities.

Volume II entitled "Bioactive Compounds from the Deep-Sea-Derived Microorganisms II" will continue to collect manuscripts that highlight the biological activities of the new secondary metabolites from deep-sea-derived microorganisms. Original research articles, reviews, and communications of the current knowledge in the field are welcome.

Prof. Dr. Xian-Wen Yang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

marine natural products
deep-sea
bioactivity
microorganisms
fungi
actinomycetes
compounds
secondary metabolites
OSMAC

Published Papers (2 papers)

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Research

14 pages, 2038 KiB

Open AccessArticle

Marine-Fungi-Derived Gliotoxin Promotes Autophagy to Suppress Mycobacteria tuberculosis Infection in Macrophage

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Mar. Drugs 2023, 21(12), 616; https://doi.org/10.3390/md21120616 - 28 Nov 2023

Viewed by 356

Abstract

The Mycobacterium tuberculosis (MTB) infection causes tuberculosis (TB) and has been a long-standing public-health threat. It is urgent that we discover novel antitubercular agents to manage the increased incidence of multidrug-resistant (MDR) or extensively drug-resistant (XDR) strains of MTB and tackle the adverse effects of the first- and second-line antitubercular drugs. We previously found that gliotoxin (1), 12, 13-dihydroxy-fumitremorgin C (2), and helvolic acid (3) from the cultures of a deep-sea-derived fungus, Aspergillus sp. SCSIO Ind09F01, showed direct anti-TB effects. As macrophages represent the first line of the host defense system against a mycobacteria infection, here we showed that the gliotoxin exerted potent anti-tuberculosis effects in human THP-1-derived macrophages and mouse-macrophage-leukemia cell line RAW 264.7, using CFU assay and laser confocal scanning microscope analysis. Mechanistically, gliotoxin apparently increased the ratio of LC3-II/LC3-I and Atg5 expression, but did not influence macrophage polarization, IL-1β, TNF-a, IL-10 production upon MTB infection, or ROS generation. Further study revealed that 3-MA could suppress gliotoxin-promoted autophagy and restore gliotoxin-inhibited MTB infection, indicating that gliotoxin-inhibited MTB infection can be treated through autophagy in macrophages. Therefore, we propose that marine fungi-derived gliotoxin holds the promise for the development of novel drugs for TB therapy. Full article

(This article belongs to the Special Issue Bioactive Compounds from the Deep-Sea-Derived Microorganisms 2nd Edition)

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14 pages, 8772 KiB

Open AccessArticle

Citriquinolinones A and B: Rare Isoquinolinone-Embedded Citrinin Analogues and Related Metabolites from the Deep-Sea-Derived Aspergillus versicolor 170217

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Mar. Drugs 2023, 21(10), 504; https://doi.org/10.3390/md21100504 - 23 Sep 2023

Cited by 1 | Viewed by 808

Abstract

A systematic chemical investigation of the deep-sea-derived fungus Aspergillus versicolor 170217 resulted in the isolation of six new (1–6) and 45 known (7–51) compounds. The structures of the new compounds were established on the basis of exhaustive analysis of their spectroscopic data and theoretical–statistical approaches including GIAO-NMR, TDDFT-ECD/ORD calculations, DP4+ probability analysis, and biogenetic consideration. Citriquinolinones A (1) and B (2) feature a unique isoquinolinone-embedded citrinin scaffold, representing the first exemplars of a citrinin–isoquinolinone hybrid. Dicitrinones K–L (3–4) are two new dimeric citrinin analogues with a rare CH-CH₃ bridge. Biologically, frangula-emodin (32) and diorcinol (17) displayed remarkable anti-food allergic activity with IC₅₀ values of 7.9 ± 3.0 μM and 13.4 ± 1.2 μM, respectively, while diorcinol (17) and penicitrinol A (20) exhibited weak inhibitory activity against Vibrio parahemolyticus, with MIC values ranging from 128 to 256 μM. Full article

(This article belongs to the Special Issue Bioactive Compounds from the Deep-Sea-Derived Microorganisms 2nd Edition)

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