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The Gift of Marine Fungi: Abundant Secondary Metabolites
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The Gift of Marine Fungi: Abundant Secondary Metabolites

A special issue of Journal of Fungi (ISSN 2309-608X).

Deadline for manuscript submissions: 31 October 2024 | Viewed by 2193

Special Issue Editors

Prof. Dr. Ling Liu

E-Mail Website
Guest Editor
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Interests: fungal secondary metabolites; marine natural products; drug discovery; genome mining; biosynthesis
Special Issues, Collections and Topics in MDPI journals
Dr. Mancheng Tang

E-Mail Website
Guest Editor
State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
Interests: biosynthesis; natural products; marine fungi; genome mining; biocatalyst; synthetic biology

Special Issue Information

Dear Colleagues,

Fungi are well-known for their ability to synthesize secondary metabolites with novel scaffolds and diverse bioactivities. Marine-derived fungi, living under extreme environmental conditions such as high salinity, intensely high pressure, absence of sunlight, and deficiency of nutrients, could evolve a more specific metabolic mechanism to produce unique secondary metabolites. Discoveries of new natural products from marine fungi have increased dramatically over the last few decades. Marine-derived fungi have been proven to be a prolific source of biologically active and structurally diverse natural products. This research topic invites submissions of any contributions on bioactive natural products from marine fungi, ranging from the isolation and structure elucidation of new natural products guided by OSMAC strategy or genome mining to biosynthetic pathways of marine fungal natural products.

As Guest Editors for this Special Issue, we invite you to submit your research results on marine fungi as a source of bioactive secondary metabolites.

Dr. Ling Liu
Dr. Mancheng Tang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • marine fungi
  • bioactivity
  • structure elucidation
  • natural products
  • new strategies
  • biosynthetic gene clusters

Published Papers (1 paper)

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Research

13 pages, 2782 KiB  
Article
Development of Marker Recycling Systems for Sequential Genetic Manipulation in Marine-Derived Fungi Spiromastix sp. SCSIO F190 and Aspergillus sp. SCSIO SX7S7
by Yingying Chen, Jiafan Yang, Cunlei Cai, Junjie Shi, Yongxiang Song, Junying Ma and Jianhua Ju
J. Fungi 2023, 9(3), 302; https://doi.org/10.3390/jof9030302 - 26 Feb 2023
Cited by 1 | Viewed by 1677
Abstract
Marine-derived fungi are emerging as prolific workhorses of structurally novel natural products (NPs) with diverse bioactivities. However, the limitation of available selection markers hampers the exploration of cryptic NPs. Recyclable markers are therefore valuable assets in genetic engineering programs for awaking silent SM [...] Read more.
Marine-derived fungi are emerging as prolific workhorses of structurally novel natural products (NPs) with diverse bioactivities. However, the limitation of available selection markers hampers the exploration of cryptic NPs. Recyclable markers are therefore valuable assets in genetic engineering programs for awaking silent SM clusters. Here, both pyrG and amdS-based recyclable marker cassettes were established and successfully applied in marine-derived fungi Aspergillus sp. SCSIO SX7S7 and Spiromastix sp. SCSIO F190, respectively. Using pyrG recyclable marker, a markerless 7S7-∆depH strain with a simplified HPLC background was built by inactivating a polyketide synthase (PKS) gene depH and looping out the pyrG recyclable marker after depH deletion. Meanwhile, an amdS recyclable marker system was also developed to help strains that are difficult to use pyrG marker. By employing the amdS marker, a backbone gene spm11 responsible for one major product of Spiromastix sp. SCSIO F190 was inactivated, and the amdS marker was excised after using, generating a relatively clean F190-∆spm11 strain for further activation of novel NPs. The collection of two different recycle markers will guarantee flexible application in marine-derived fungi with different genetic backgrounds, enabling the exploitation of novel structures in various fungi species with different genome mining strategies. Full article
(This article belongs to the Special Issue The Gift of Marine Fungi: Abundant Secondary Metabolites)
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