Special Issue "Marine Natural Products and Signaling Pathways"

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 29 February 2024 | Viewed by 228

Special Issue Editors

Dr. Haifeng Wang
E-Mail Website
Guest Editor
Key Laboratory of Structure-Based Drug Design & Discovery of Education, College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
Interests: marine natural products; antitumor; sponge; fungi; signaling pathway
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Interests: fungal secondary metabolites; marine natural products; drug discovery; genome mining; biosynthesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Marine natural products, as the bioactive products of secondary metabolites, including enzymes, lipids, and heteropolysaccharides, have played a crucial role in the discovery of novel lead compounds. The characteristics of abundant water, high salinity, high pressure, low temperature, flow, and complexity in the marine environment make the structural configurations of marine natural products more diverse, unique, and novel. Marine natural products possess unique regulatory mechanisms for combating different diseases, including apoptosis, autophagy, the Hippo signaling pathway, Jak STAT and the mTOR signaling pathway.

This Special Issue mainly focuses on the relationship between various natural products derived from marine sources and disease-related signaling pathways. It encourages the contribution of studies addressing new pathways for known components, or the study of pathways for the disocvery of novel molecules. Research articles and reviews that combine the above conditions are welcome for submission.

Dr. Haifeng Wang
Dr. Ling Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • marine natural products
  • signaling pathways
  • active molecules
  • novel molecular skeleton
  • regulation mechanism
  • omics

Published Papers (1 paper)

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43 pages, 7157 KiB  
Deep-Sea Sponges and Corals off the Western Coast of Florida—Intracellular Mechanisms of Action of Bioactive Compounds and Technological Advances Supporting the Drug Discovery Pipeline
Mar. Drugs 2023, 21(12), 615; https://doi.org/10.3390/md21120615 - 28 Nov 2023
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The majority of natural products utilized to treat a diverse array of human conditions and diseases are derived from terrestrial sources. In recent years, marine ecosystems have proven to be a valuable resource of diverse natural products that are generated to defend and [...] Read more.
The majority of natural products utilized to treat a diverse array of human conditions and diseases are derived from terrestrial sources. In recent years, marine ecosystems have proven to be a valuable resource of diverse natural products that are generated to defend and support their growth. Such marine sources offer a large opportunity for the identification of novel compounds that may guide the future development of new drugs and therapies. Using the National Oceanic and Atmospheric Administration (NOAA) portal, we explore deep-sea coral and sponge species inhabiting a segment of the U.S. Exclusive Economic Zone, specifically off the western coast of Florida. This area spans ~100,000 km2, containing coral and sponge species at sea depths up to 3000 m. Utilizing PubMed, we uncovered current knowledge on and gaps across a subset of these sessile organisms with regards to their natural products and mechanisms of altering cytoskeleton, protein trafficking, and signaling pathways. Since the exploitation of such marine organisms could disrupt the marine ecosystem leading to supply issues that would limit the quantities of bioactive compounds, we surveyed methods and technological advances that are necessary for sustaining the drug discovery pipeline including in vitro aquaculture systems and preserving our natural ecological community in the future. Collectively, our efforts establish the foundation for supporting future research on the identification of marine-based natural products and their mechanism of action to develop novel drugs and therapies for improving treatment regimens of human conditions and diseases. Full article
(This article belongs to the Special Issue Marine Natural Products and Signaling Pathways)
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