Submit to JoF Review for JoF Propose a Special Issue

Journal Menu

Journal Browser

Special Issue "Diversity, Pathogenicity and Drug Resistance of Medically Important Fungi"

Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: closed (10 September 2023) | Viewed by 3584

Share This Special Issue

Special Issue Editor

Prof. Dr. Richard D. Cannon

E-Mail Website
Guest Editor

Sir John Walsh Research Institute, University of Otago Faculty of Dentistry, P.O. Box 56, Dunedin 9054, New Zealand
Interests: oral microbiology; antifungal drug resistance; antifungal drug discovery; oral adhesion; Candida albicans
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Many fungi are opportunistic pathogens that cause infections when host defences are impaired. There are an increasing number of ways in which people are becoming immunocompromised. Medical treatments for cancer, immunosuppression for organ transplantation, the deterioration of immune defences due to ageing and stress on the immune system from other microbial infections, including COVID-19, can all have an effect on fungal infections. Therefore, it is important to have up-to-date information on the diversity of fungi causing infections in humans. While the pathogenicity of certain fungi has been extensively studied, there is a need to understand the pathogenesis of emerging fungal infections. Understanding how fungi cause disease and interact with host defences can inform the development of new drugs and novel treatment or prophylaxis as well as strategies. With the limited antifungal armamentarium currently available, understanding trends in the prevalence and nature of antifungal drug resistance is paramount. This Special Issue will collate important reports and reviews on the diversity of fungi currently causing fungal infections in humans, their pathogenicity, drug susceptibility and mechanisms of drug resistance.

Prof. Dr. Richard D. Cannon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

emerging fungal diseases
fungal diversity
fungal disease prevalence
pathogenesis
fungal drug resistance

Published Papers (4 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

Jump to: Review

Open AccessArticle

Trends in the Epidemiological and Clinical Profile of Paracoccidioidomycosis in the Endemic Area of Rio de Janeiro, Brazil

Eduardo Mastrangelo Marinho Falcão

Dayvison Francis Saraiva Freitas

Ziadir Francisco Coutinho

Leonardo Pereira Quintella

Mauro de Medeiros Muniz

Rodrigo Almeida-Paes

Rosely Maria Zancopé-Oliveira

Priscila Marques de Macedo

and

Antonio Carlos Francesconi do Valle

J. Fungi 2023, 9(9), 946; https://doi.org/10.3390/jof9090946 - 20 Sep 2023

Viewed by 298

Abstract

Paracoccidioidomycosis (PCM) is a neglected endemic mycosis in Latin America. Most cases occur in Brazil. It is classified as PCM infection and PCM disease and is subdivided into chronic (adult type) or acute (juvenile type) disease, with the latter being less frequent and more severe. In 2016, we reported an increase in the numbers of patients diagnosed with acute PCM after a highway’s construction. We conducted a study at INI-Fiocruz, a reference center for infectious diseases, including endemic mycoses, in Rio de Janeiro, Brazil, aiming to deepen the analysis of this new clinical and epidemiological profile of PCM. The authors developed a retrospective study including 170 patients diagnosed with PCM between 2010 and 2019. There was an increase in the number of atypical and severe forms, starting in 2014. In subsequent years, we detected a higher incidence of adverse outcomes with patients requiring more hospitalizations and an increased mortality rate. We estimate that PCM has become more severe throughout the Rio de Janeiro state, affecting a greater number of young individuals and leading to a greater number of and longer hospitalizations. Surveillance measures and close monitoring of future notification data in the state, with emphasis on children, adolescents, and young adults are necessary for a better understanding of the perpetuation of this public health challenge. Full article

(This article belongs to the Special Issue Diversity, Pathogenicity and Drug Resistance of Medically Important Fungi)

► Show Figures

Figure 1

Open AccessArticle

Fast and Accurate Identification of Candida auris by High Resolution Mass Spectrometry

and

J. Fungi 2023, 9(2), 267; https://doi.org/10.3390/jof9020267 - 16 Feb 2023

Viewed by 1411

Abstract

The emerging pathogen Candida auris has been associated with nosocomial outbreaks on six continents. Genetic analysis indicates simultaneous and independent emergence of separate clades of the species in different geographical locations. Both invasive infection and colonization have been observed, warranting attention due to variable antifungal resistance profiles and hospital transmission. MALDI-TOF based identification methods have become routine in hospitals and research institutes. However, identification of the newly emerging lineages of C. auris yet remains a diagnostic challenge. In this study an innovative liquid chromatography (LC)—high resolution Orbitrap^TM mass spectrometry method was used for identification of C. auris from axenic microbial cultures. A set of 102 strains from all five clades and different body locations were investigated. The results revealed correct identification of all C. auris strains within the sample cohort, with an identification accuracy of 99.6% from plate culture, in a time-efficient manner. Furthermore, application of the applied mass spectrometry technology provided the species identification down to clade level, thus potentially providing the possibility for epidemiological surveillance to track pathogen spread. Identification beyond species level is required specially to differentiate between nosocomial transmission and repeated introduction to a hospital. Full article

(This article belongs to the Special Issue Diversity, Pathogenicity and Drug Resistance of Medically Important Fungi)

► Show Figures

Figure 1

Open AccessArticle

What Is Hiding in the Israeli Mediterranean Seawater and Beach Sand

and

J. Fungi 2022, 8(9), 950; https://doi.org/10.3390/jof8090950 - 10 Sep 2022

Viewed by 1132

Abstract

Objective: In the present study, we aimed to investigate the presence of fungi that may affect human health in sand and water on Israeli Mediterranean Sea coast beaches. Methods: The study included screening of the sand and water of six urban beaches from north to south on the Israeli Mediterranean coast. Sand samples were extracted with water, and the water wash was cultured and quantitated. Water samples were quantitated as well. MALDI-TOF MS analysis and ITS sequencing identified the fungi. Results: The study considered several parameters: 1. Presence of fecal-contamination-related fungi; 2. Presence of dermal-infection-related fungi. 3. Presence of allergy-related fungi; 4. Presence of fungi posing risk for immunocompromised individuals. The screen revealed that about 80% of the isolates were molds and about 20% yeasts. The mold species included opportunistic pathogens and potential allergens: Aspergillus fumigatus and other Aspergillus species, Fusarium, Penicillium, and Mucorales species. Yeast isolates included Candida—including the human commensals Candida albicans and Candida tropicalis—Cryptococcus, and Rhodotorula species. Conclusions: The results suggest that beaches should be monitored for fungi for safer use, better management, and the benefit of public health. Full article

(This article belongs to the Special Issue Diversity, Pathogenicity and Drug Resistance of Medically Important Fungi)

► Show Figures

Figure 1

Review

Jump to: Research

Open AccessReview

Oral Manifestations of Mucormycosis: A Systematic Review

Alejandro Mora-Martínez

Laura Murcia

and

Francisco Javier Rodríguez-Lozano

J. Fungi 2023, 9(9), 935; https://doi.org/10.3390/jof9090935 - 16 Sep 2023

Viewed by 241

Abstract

Mucormycosis is a rare, opportunistic, and emerging fungal infection that can rapidly develop into a severe, highly fatal clinical picture. In most cases, it is caused by fungi of the order Mucorales, which are usually avirulent but become pathogenic when the host’s immune system is compromised. This systematic review was conducted according to PRISMA guidelines. The databases searched included PubMed, Scopus, and Web of Science. We chose articles that analyzed the oral manifestations of patients with mucormycosis, were published between 2018 and 2023, and met our search terms. The risk of bias in the articles was assessed using the CARE guideline for case reports and STROBE for a cross-sectional study. After the selection process, 20 articles were included in this review, all containing information about the different oral manifestations presented by people with mucormycosis. The most common oral manifestations are mainly bone exposures and oral ulcers, halitosis, pus discharge, gingival thickening, and periodontitis. However, despite the importance of recognizing these oral manifestations in the early stages of mucormycotic infection, providing early treatment, and reducing the high mortality rate of the infection, more studies are needed. Full article

(This article belongs to the Special Issue Diversity, Pathogenicity and Drug Resistance of Medically Important Fungi)

► Show Figures

Journal Menu

Journal Browser

Special Issue "Diversity, Pathogenicity and Drug Resistance of Medically Important Fungi"

Share This Special Issue

Special Issue Editor

Special Issue Information

Keywords

Published Papers (4 papers)

Research

Review

Further Information

Guidelines

MDPI Initiatives

Follow MDPI