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New Biomaterials for Diagnostic and Therapeutic Strategies of Pathogenic Biofilms
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New Biomaterials for Diagnostic and Therapeutic Strategies of Pathogenic Biofilms

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 3473

Special Issue Editor

Dr. Mary Anne Melo

E-Mail Website
Guest Editor
Department of General Dentistry, University of Maryland School of Dentistry, 650 W. Baltimore St., Baltimore, MD 21201, USA
Interests: oral biofilm; dental materials; dental caries; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to demonstrate the current scenarios around new biomaterials for diagnostic and therapeutic strategies of pathogenic biofilms through original research and timely reviews on this subject.

Biofilm formation is a major concern in various sectors and causes severe public health, medicine, and industry problems. Biofilms account for up to 80% of the total number of bacteria-related infections, including endocarditis, cystic fibrosis, secondary caries, periodontitis, osteomyelitis, non-healing chronic wounds, meningitis, kidney infections, and prosthesis and implantable device-related infections.

Current research also indicates that entire microbial communities can be associated with the disease. The idea that the lack of a beneficial organism in a biofilm may be just as significant as the presence of a pathogen in the contribution to disease has led to the development of a hypothesis linking certain conditions to a shift in membership of the local microbiota, known as the “microbial shift” hypothesis. Microbial shift, more commonly known as dysbiosis, refers to the concept that some diseases are due to a decrease in the number of beneficial symbionts and an increase in pathogens.

This Special Issue calls for recent studies from various biological science and bioengineering fields composed of investigations on biomaterials and techniques to control biofilms, susceptibility to bacterial colonization, mechanisms, and clinical perspectives, among others, that envision promising solutions for bacterial-related infections.

We invite manuscripts that focus on a wide range of issues and concerns regarding “New Biomaterials for Diagnostic and Therapeutic Strategies of Pathogenic Biofilms”, including, but not limited to:

  • Antibiofilm-containing dental/medical devices;
  • Infection-resisting biomaterials;
  • Clinical perspectives of device-associated infection;
  • Microbial shift driven by therapeutic strategies;
  • Bacterial response to dental/medical materials surface;
  • Nanotechnology applied to biofilm control.

We very much look forward to your valuable contribution.

Dr. Mary Anne Melo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental Materials
  • biofilm
  • infections
  • nanotechnology
  • bacteria

Published Papers (2 papers)

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Research

19 pages, 6947 KiB  
Article
Novel Dental Low-Shrinkage-Stress Composite with Antibacterial Dimethylaminododecyl Methacrylate Monomer
by Abdullah Alhussein, Rashed Alsahafi, Xiaohong Wang, Heba Mitwalli, Hanan Filemban, Gary D. Hack, Thomas W. Oates, Jirun Sun, Michael D. Weir and Hockin H. K. Xu
J. Funct. Biomater. 2023, 14(7), 335; https://doi.org/10.3390/jfb14070335 - 25 Jun 2023
Cited by 3 | Viewed by 1243
Abstract
Objectives: Current dental resins exhibit polymerization shrinkage causing microleakage, which has the potential to cause recurrent caries. Our objectives were to create and characterize low-shrinkage-stress (LSS) composites with dimethylaminododecyl methacrylate (DMADDM) as an antibacterial agent to combat recurrent caries. Methods: Triethylene glycol divinylbenzyl [...] Read more.
Objectives: Current dental resins exhibit polymerization shrinkage causing microleakage, which has the potential to cause recurrent caries. Our objectives were to create and characterize low-shrinkage-stress (LSS) composites with dimethylaminododecyl methacrylate (DMADDM) as an antibacterial agent to combat recurrent caries. Methods: Triethylene glycol divinylbenzyl ether and urethane dimethacrylate were used to reduce shrinkage stress. DMADDM was incorporated at different mass fractions (0%, 1.5%, 3%, and 5%). Flexural strength, elastic modulus, degree of conversion, polymerization stress, and antimicrobial activity were assessed. Results: The composite with 5% DMADDM demonstrated higher flexural strength than the commercial group (p < 0.05). The addition of DMADDM in BisGMA-TEGDMA resin and LSS resin achieved clinically acceptable degrees of conversion. However, LSS composites exhibited much lower polymerization shrinkage stress than BisGMA-TEGDMA composite groups (p < 0.05). The addition of 3% and 5% DMADDM showed a 6-log reduction in Streptococcus mutans (S. mutans) biofilm CFUs compared to commercial control (p < 0.001). Biofilm biomass and lactic acid were also substantially decreased via DMADDM (p < 0.05). Conclusions: The novel LSS dental composite containing 3% DMADDM demonstrated potent antibacterial action against S. mutans biofilms and much lower polymerization shrinkage-stress, while maintaining excellent mechanical characteristics. The new composite is promising for dental applications to prevent secondary caries and increase restoration longevity. Full article
(This article belongs to the Special Issue New Biomaterials for Diagnostic and Therapeutic Strategies of Pathogenic Biofilms)
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14 pages, 4579 KiB  
Article
Benzyldimethyldodecyl Ammonium Chloride Doped Dental Adhesive: Impact on Core’s Properties, Biosafety, and Antibacterial/Bonding Performance after Aging
by Lamia Sami Mokeem, Abdulrahman A. Balhaddad, Isadora Martini Garcia, Fabrício Mezzomo Collares and Mary Anne S. Melo
J. Funct. Biomater. 2022, 13(4), 190; https://doi.org/10.3390/jfb13040190 - 17 Oct 2022
Cited by 5 | Viewed by 1706
Abstract
Current dental adhesives lack antibacterial properties. This study aimed to explore the effect of incorporating benzyldimethyldodecyl ammonium chloride (BDMDAC) on the degree of conversion, contact angle, ultimate tensile strength (UTS), microtensile bond strength (µTBS), cytotoxicity, antibacterial and bonding performance after artificial aging. A [...] Read more.
Current dental adhesives lack antibacterial properties. This study aimed to explore the effect of incorporating benzyldimethyldodecyl ammonium chloride (BDMDAC) on the degree of conversion, contact angle, ultimate tensile strength (UTS), microtensile bond strength (µTBS), cytotoxicity, antibacterial and bonding performance after artificial aging. A dental adhesive was doped with BDMDAC in the concentration range of 1–5 wt.%. For antibacterial assays, the BDMDAC compound was subject to planktonic cells of Streptococcus mutans. Then, after incorporation into the dental adhesive, an S. mutans biofilm model was used to grow 48 h-mature biofilms. The biofilms grown over the formulated materials were assessed by colony-forming unit (CFU) counting assay and fluorescence microscopy staining. In addition, the cytotoxicity was evaluated. Samples were subjected to 10,000 thermal cycles for aging and evaluated by UTS, µTBS, and CFU. Incorporating BDMDAC did not increase the cytotoxicity or change the physical properties when the mass fraction of the BDMDAC was 1–5 wt.%. The UTS of BDMDAC-doped adhesives was not impaired immediately or over time. A significant bacterial reduction was obtained for the mass fraction of the BDMDAC greater than 3 wt.%. However, the BDMDAC-doped adhesives did not offer an antibacterial effect after artificial aging. The overall results indicate that the BDMDAC strategy has the potential to control of microbial growth of cariogenic planktonic cells and biofilms. However, other new technological approaches are needed to overcome the deleterious effect of BDMDAC release over time such as those based on the principle of drug delivery systems whereby the BDMDAC is transported on microparticles or core shells, providing tangible benefits to oral health over time. Full article
(This article belongs to the Special Issue New Biomaterials for Diagnostic and Therapeutic Strategies of Pathogenic Biofilms)
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