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Special Issue "Clinical Utility of Optical Coherence Tomography in Ophthalmology"

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A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 25 August 2023 | Viewed by 1982

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Dr. José Ignacio Fernández-Vigo

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Guest Editor

1. Department of Ophthalmology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria (IdISSC), Madrid, Spain
2. Department of Ophthalmology, Centro Internacional de Oftalmología Avanzada, Madrid, Spain
Interests: optical coherence tomography; OCT; retinal diseases; vitreoretinal surgery; macular degeneration; glaucoma; retinal imaging; ophthalmology

Special Issue Information

Dear Colleagues,

The continuous development of optical coherence tomography (OCT) in the ophthalmology field has revolutionized its clinical practice. In the beginning, it was developed for ophthalmology with the aim of evaluating the posterior segment, mainly the macula and the optic nerve. Shortly after, it was employed for the assessment of the anterior segment, expanding its usefulness and resulting in focused study of the cornea, anterior chamber, and iridocorneal angle. Through OCT, it is now possible to examine structures that were previously difficult to assess, such as the choroid, vitreous, lens, extraocular muscles, or ciliary muscle.

Recently, intraoperative OCT, en face OCT, and wide-field OCT have been developed, offering new insights into surgical maneuvers and a variety of diseases. Moreover, analysis of the changes after surgery in different ophthalmological subspecialties, including retina, cornea, or glaucoma, has become more accurate with the progress in OCT.

This Special Issue aims to present selected original research papers and review articles that discuss the current state-of-the-art, address existing knowledge gaps, and present the clinical utility of such advances in OCT, focusing on their clinical impacts on the management of different ophthalmological diseases.

Dr. José Ignacio Fernández-Vigo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

optical coherence tomography
ophthalmology
intraoperative OCT
En face OCT
wide-field OCT
retinal diseases
glaucoma
cornea
strabismus
cataract

Published Papers (3 papers)

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Research

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Open AccessArticle

Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System

José Ignacio Fernández-Vigo

Bárbara Burgos-Blasco

Lucía De-Pablo-Gómez-de-Liaño

Inés Sánchez-Guillén

Virginia Albitre-Barca

Susana Fernández-Aragón

José Ángel Fernández-Vigo

and

Ana Macarro-Merino

J. Clin. Med. 2023, 12(6), 2351; https://doi.org/10.3390/jcm12062351 - 17 Mar 2023

Cited by 2 | Viewed by 537

Abstract

Purpose: To propose a classification of the glistening in intraocular lenses (IOL) using swept-source optical coherence tomography (SS-OCT) by means of a simple, objective and reproducible method that allows the quantification of the presence and severity of glistening. Methods: A cross-sectional study on a sample of 150 eyes of 150 patients who underwent cataract surgery in at least 600 days before the exam and attended a routine examination. Each subject was examined by SS-OCT after pupil dilation, identifying the presence of glistening or hyperreflective foci (HRF) in the central area of the IOL. The degree of glistening was classified into four categories: 0: ≤5 HRF; 1: 6 to 15 HRF; 2: 16 to 30 HRF; and 3: >30 HRF. The intra and interobserver reproducibility (intraclass correlation coefficient, ICC) in the quantification and classification of the glistening were calculated. The correlation between the horizontal and vertical scan of the IOL was also assessed. Results: Glistening was present in the IOL in 42.7% of the patients. The mean number of HRF or glistening microvacuoles was 10.4 ± 26.2 (range 0 to 239). In total, 63.3% of the IOLs had a grade 0, 20% grade a 1, 6.7% grade a 2 and 10% a grade 3. The intraobserver and interobserver reproducibility were very high, both for the absolute quantification of the glistening (ICC ≥ 0.994) and for the severity scale (ICC ≥ 0.967). There was an excellent correlation in the quantification of the IOL glistening between the horizontal and vertical scans (R ≥ 0.834; p < 0.001). Conclusions: The use of SS-OCT makes it possible to identify, quantify and classify IOL glistening in a simple, objective and reproducible way. This technique could provide relevant information for the study of the glistening on IOLs. Full article

(This article belongs to the Special Issue Clinical Utility of Optical Coherence Tomography in Ophthalmology)

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Open AccessArticle

Intervortex Venous Anastomosis in the Macula in Central Serous Chorioretinopathy Imaged by En Face Optical Coherence Tomography

José Ignacio Fernández-Vigo

Daniela Rego-Lorca

Francisco Javier Moreno-Morillo

Bárbara Burgos-Blasco

Alicia Valverde-Megías

Carmen Méndez-Hernández

Lorenzo López-Guajardo

and

Juan Donate-López

J. Clin. Med. 2023, 12(6), 2088; https://doi.org/10.3390/jcm12062088 - 07 Mar 2023

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Abstract

Purpose: To assess the presence of macular intervortex venous anastomosis in central serous chorioretinopathy (CSCR) patients using en face optical coherence tomography (EF-OCT). Methods: A cross-sectional study where EF-OCT 6 × 6 and 12 × 12 mm macular scans of patients with unilateral chronic CSCR were evaluated for anastomosis between vortex vein systems in the central macula. The presence of prominent anastomoses was defined as a connection with a diameter ≥150 µm between the inferotemporal and superotemporal vortex vein systems which crossed the temporal raphe. Three groups were studied: CSCR eyes (with an active disease with the presence of neurosensorial detachment; n = 135), fellow unaffected eyes (n = 135), and healthy eyes as controls (n = 110). Asymmetries, abrupt termination, sausaging, bulbosities and corkscrew appearance were also assessed. Results: In 79.2% of the CSCR eyes there were prominent anastomoses in the central macula between the inferotemporal and superotemporal vortex vein systems, being more frequent than in fellow eyes and controls (51.8% and 58.2% respectively). The number of anastomotic connections was higher in the affected eye group (2.9 ± 1.8) than in the unaffected fellow eye group (2.1 ± 1.7) and the controls (1.5 ± 1.6) (p < 0.001). Asymmetry, abrupt terminations and the corkscrew appearance of the choroidal vessels were more frequent in the affected eyes, although no differences in sausaging or bulbosities were observed. Conclusions: Intervortex venous anastomoses in the macula were common in CSCR, being more frequently observed in affected eyes than in fellow unaffected eyes and healthy controls. This anatomical variation could have important implications concerning the pathogenesis and classification of the disease. Full article

(This article belongs to the Special Issue Clinical Utility of Optical Coherence Tomography in Ophthalmology)

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Review

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Open AccessReview

Update on the Utility of Optical Coherence Tomography in the Analysis of the Optic Nerve Head in Highly Myopic Eyes with and without Glaucoma

Bachar Kudsieh

José Ignacio Fernández-Vigo

Ignacio Flores-Moreno

Jorge Ruiz-Medrano

Maria Garcia-Zamora

Muhsen Samaan

and

Jose Maria Ruiz-Moreno

J. Clin. Med. 2023, 12(7), 2592; https://doi.org/10.3390/jcm12072592 - 29 Mar 2023

Viewed by 692

Abstract

Glaucoma diagnosis in highly myopic subjects by optic nerve head (ONH) imaging is challenging as it is difficult to distinguish structural defects related to glaucoma from myopia-related defects in these subjects. Optical coherence tomography (OCT) has evolved to become a routine examination at present, providing key information in the assessment of glaucoma based on the study of the ONH. However, the correct segmentation and interpretation of the ONH data employing OCT is still a challenge in highly myopic patients. High-resolution OCT images can help qualitatively and quantitatively describe the structural characteristics and anatomical changes in highly myopic subjects with and without glaucoma. The ONH and peripapillary area can be analyzed to measure the myopic atrophic-related zone, the existence of intrachoroidal cavitation, staphyloma, and ONH pits by OCT. Similarly, the lamina cribosa observed in the OCT images may reveal anatomical changes that justify visual defects. Several quantitative parameters of the ONH obtained from OCT images were proposed to predict the progression of visual defects in glaucoma subjects. Additionally, OCT images help identify factors that may negatively influence the measurement of the retinal nerve fiber layer (RNFL) and provide better analysis using new parameters, such as Bruch’s Membrane Opening-Minimum Rim Width, which serves as an alternative to RNFL measurements in highly myopic subjects due to its superior diagnostic ability. Full article

(This article belongs to the Special Issue Clinical Utility of Optical Coherence Tomography in Ophthalmology)

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Special Issue "Clinical Utility of Optical Coherence Tomography in Ophthalmology"

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