Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.8
5.6
Journals
IJMS
Special Issues
Protein Biosynthesis and Drug Design & Delivery Processes
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Protein Biosynthesis and Drug Design & Delivery Processes

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 December 2022) | Viewed by 8140

Special Issue Editor

Prof. Dr. Mahesh Narayan

E-Mail Website
Guest Editor
Department of Chemistry and Biochemistry, University of Texas at El Paso (UTEP), El Paso, TX 79968, USA
Interests: protein folding; docking; halogen bonding; reactive oxygen species; neurodegenerative disorders; drug-discovery; chemical education
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

From the initial, epoch-making work of Bruce Merrifield and solid-phase peptide synthesis, the era of protein biosynthesis, along with drug-delivery and processes, has come a long way. Having mastered methods to introduce unnatural amino acids, and moieties of interest into protein chains, we are now firmly in the era of biologicals. Matching these efforts and surpassing them will enable us to make inroads into drug-design and delivery processes. While in silico computational approaches remain the mainstay of the drug development pipeline, novel delivery systems embrace nanotechnology to enhance delivery efficacy and specificity.

In this Special Issue, we cover advances in protein biosynthesis, drug-design, and delivery processes and remark on the future of these arenas.

Prof. Dr. Mahesh Narayan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • protein folding
  • small molecule drivers of therapy
  • computational chemistry
  • AI/ML
  • post-translational modifications
  • COVID
  • carbon nano materials

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

22 pages, 10294 KiB  
Article
Emergence of Nanoscale Drug Carriers through Supramolecular Self-Assembly of RNA with Calixarene
by Ruslan Kashapov, Yuliya Razuvayeva, Nadezda Kashapova, Albina Ziganshina, Vadim Salnikov, Anastasiia Sapunova, Alexandra Voloshina and Lucia Zakharova
Int. J. Mol. Sci. 2023, 24(9), 7911; https://doi.org/10.3390/ijms24097911 - 26 Apr 2023
Viewed by 1333
Abstract
Supramolecular self-assembly is a powerful tool for the development of polymolecular assemblies that can form the basis of useful nanomaterials. Given the increasing popularity of RNA therapy, the extension of this concept of self-assembly to RNA is limited. Herein, a simple method for [...] Read more.
Supramolecular self-assembly is a powerful tool for the development of polymolecular assemblies that can form the basis of useful nanomaterials. Given the increasing popularity of RNA therapy, the extension of this concept of self-assembly to RNA is limited. Herein, a simple method for the creation of nanosized particles through the supramolecular self-assembly of RNA with a three-dimensional macrocycle from the calixarene family was reported for the first time. This self-assembly into nanoparticles was realized using cooperative supramolecular interactions under mild conditions. The obtained nanoparticles are able to bind various hydrophobic (quercetin, oleic acid) and hydrophilic (doxorubicin) drugs, as a result of which their cytotoxic properties are enhanced. This work demonstrates that intermolecular interactions between flexible RNA and rigid calixarene is a promising route to bottom-up assembly of novel supramolecular soft matter, expanding the design possibilities of nanoscale drug carriers. Full article
(This article belongs to the Special Issue Protein Biosynthesis and Drug Design & Delivery Processes)
►▼ Show Figures

Graphical abstract

19 pages, 7012 KiB  
Article
Carboxyl Functionalization of N-MWCNTs with Stone–Wales Defects and Possibility of HIF-1α Wave-Diffusive Delivery
by Vladislav V. Shunaev, Nadezhda G. Bobenko, Petr M. Korusenko, Valeriy E. Egorushkin and Olga E. Glukhova
Int. J. Mol. Sci. 2023, 24(2), 1296; https://doi.org/10.3390/ijms24021296 - 09 Jan 2023
Cited by 1 | Viewed by 2261
Abstract
Nitrogen-doped multi-walled carbon nanotubes (N-MWCNTs) are widely used for drug delivery. One of the main challenges is to clarify their interaction with hypoxia-inducible factor 1 alpha (HIF-1α), the lack of which leads to oncological and cardiovascular diseases. In the presented study, N-MWCNTs were [...] Read more.
Nitrogen-doped multi-walled carbon nanotubes (N-MWCNTs) are widely used for drug delivery. One of the main challenges is to clarify their interaction with hypoxia-inducible factor 1 alpha (HIF-1α), the lack of which leads to oncological and cardiovascular diseases. In the presented study, N-MWCNTs were synthesized by catalytic chemical vapor deposition and irradiated with argon ions. Their chemical state, local structure, interfaces, Stone–Wales defects, and doping with nitrogen were analyzed by high resolution transmission electron microscopy (HRTEM), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and near-edge X-ray absorption fine structure (NEXAFS) spectroscopy. Using experimental data, supercells of functionalized N-MWCNTs with an oxygen content of 2.7, 4 and 6 at. % in carboxyl groups were built by quantum chemical methods. Our analysis by the self-consistent charge density functional tight-binding (SCC DFTB) method shows that a key role in the functionalization of CNTs with carboxyl groups belongs to Stone–Wales defects. The results of research in the decoration of CNTs with HIF-1α demonstrate the possibility of wave-diffusion drug delivery. The nature of hybridization and relaxation determines the mechanism of oxygen regulation with HIF-1α molecules, namely, by OH-(OH–C) and OH-(O=C) chemical bonds. The concentration dependence of drug release in the diffusion mode suggests that the best pattern for drug delivery is provided by the tube with a carboxylic oxygen content of 6 at. %. Full article
(This article belongs to the Special Issue Protein Biosynthesis and Drug Design & Delivery Processes)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

31 pages, 2302 KiB  
Review
Gelatin as It Is: History and Modernity
by Oleg V. Mikhailov
Int. J. Mol. Sci. 2023, 24(4), 3583; https://doi.org/10.3390/ijms24043583 - 10 Feb 2023
Cited by 16 | Viewed by 3877
Abstract
The data concerning the synthesis and physicochemical characteristics of one of the practically important proteins—gelatin, as well as the possibilities of its practical application, are systematized and discussed. When considering the latter, emphasis is placed on the use of gelatin in those areas [...] Read more.
The data concerning the synthesis and physicochemical characteristics of one of the practically important proteins—gelatin, as well as the possibilities of its practical application, are systematized and discussed. When considering the latter, emphasis is placed on the use of gelatin in those areas of science and technology that are associated with the specifics of the spatial/molecular structure of this high-molecular compound, namely, as a binder for the silver halide photographic process, immobilized matrix systems with a nano-level organization of an immobilized substance, matrices for creating pharmaceutical/dosage forms and protein-based nanosystems. It was concluded that the use of this protein is promising in the future. Full article
(This article belongs to the Special Issue Protein Biosynthesis and Drug Design & Delivery Processes)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop