Mitochondrial Research: Yeast and Human Cells as Models 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (25 November 2023) | Viewed by 7791
Special Issue Editors
Interests: yeast; mitochondria; cell death; cancer; drug discovery
Special Issues, Collections and Topics in MDPI journals
Interests: cancer metabolism; mitochondria; cell signalling
Interests: mitochondrial proteome in aging; muscle unloading; cancer; mitochondrial biogenesis; mitochondrial antioxidant proteins; mitochondrial DNA-binding proteins; mitochondrial dynamics; metabolomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the continuation of our previous Special Issue "Mitochondrial Research: Yeast and Human Cells as Models".
It has been over twenty years since cytochrome c release from mitochondria was revealed as a key step in the initiation of apoptotic cell death, and since then, mitochondrial research has experienced a tremendous boost. Researchers have amassed a growing wealth of knowledge that recognizes the central role of these organelles in the maintenance of eukaryotic cell homeostasis. This role is not restricted to the generation of intermediary metabolites and ATP production through the tricarboxylic acid cycle and oxidative phosphorylation. Not only can mitochondria synthesize fundamental molecules, such as heme and iron–sulfur clusters, but they are also major sites of amino acid, nucleotide, and fatty acid metabolism, and can receive, integrate, and relay intracellular signals.
Mitochondrial biogenesis and functions are under tight nuclear control through the so-called anterograde regulation of gene expression. This involves signaling pathways that coordinate gene transcription to tune finely metabolic requirements with nutritional and environmental cues. On the other hand, environmental changes trigger intracellular stress responses, which may disturb mitochondrial structure and/or function. To maintain cell homeostasis, damaged mitochondria relay signals through retrograde, instead of to anterograde, communication pathways that drive specific nuclear gene-transcription patterns in response to stress. Recent advances, made primarily in budding yeast, have provided novel insights into the existence of distinct microdomains between intracellular organelles, known as membrane contact sites, that coordinate diverse activities, including mitochondrial dynamics and cell-stress signaling pathways. Finally, it is becoming increasingly clear that mitochondrial and cytosolic proteostasis are intimately related.
In view of this, and following the discovery of pathogenic mitochondrial DNA defects in the 1980s, mitochondrial dysfunction is now recognized as a common factor underlying many pathological conditions. Many of these advancements would not have been possible without the model organism Saccharomyces cerevisiae and human cell lines. This Special Issue will present and discuss achievements and perspectives in the research on the multiple pathways of crosstalk between mitochondria and other cell organelles and components in the form of research or review articles. At the cutting edge of cell biology research, the results of these studies will lay the foundations for the elucidation of mitochondrial physiology at a systems biology level.
Prof. Dr. Sergio Giannattasio
Dr. Maša Ždralević
Dr. Clara Musicco
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- mitochondria
- OXPHOS
- mtDNA
- energy metabolism
- ROS
- interorganelle communication
- proteostasis
- mitochondrial dynamics
- contact sites
- yeast
- human cell lines
