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Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, titled "Stress Response Research: Yeast as Models".

Saccharomyces cerevisiae yeast was among the first living beings to be domesticated, and it is used as a "cell factory" for the production of biological drugs such as insulin and other valuable molecules. It has also been used as a model to elucidate the molecular mechanisms underlying biological processes, such as the cell cycle, DNA replication, the regulation of gene expression, aging, and regulated cell death, which are crucial processes in cell stress response and the maintenance of cellular homeostasis. The elucidation of these processes is essential for understanding the molecular mechanisms underlying human disease and for biotechnological applications. This Special Issue aims to collect emerging concepts in the field of cell stress response, using yeast as a model system. The topics of interest for this Special Issue include the following: molecular pathways of cell stress response, signal transduction and protein trafficking, aging, and regulated cell death, as well as organelle biogenesis, function, and communication.

Dr. Cristina Mazzoni
Dr. Sergio Giannattasio
Guest Editors

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Keywords

yeast
stress response
genetic disease
age-related disease
cell factory

Published Papers (1 paper)

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Research

11 pages, 1220 KiB

Open AccessArticle

Unraveling the Anti-Aging Properties of Phycocyanin from the Cyanobacterium Spirulina (Arthrospira platensis)

by Mariachiara Nova, Stefania Citterio, Enzo Martegani and Sonia Colombo

Int. J. Mol. Sci. 2024, 25(8), 4215; https://doi.org/10.3390/ijms25084215 - 11 Apr 2024

Viewed by 359

Abstract

In recent years, marine natural products have become one of the most important resources of novel lead compounds for critical diseases associated with age. Spirulina, a dietary supplement made from blue-green algae (cyanobacteria: scientific name Arthrospira platensis), is particularly rich in phycocyanin, a phycobiliprotein, which accounts for up to 20% of this cyanobacterium’s dry weight and is considered responsible for its anti-cancer, anti-inflammatory and antioxidant activities. Although the anti-aging activity of phycocyanin has been investigated, how exactly this compound works against aging remains elusive. The aim of our research is to use the yeast Saccharomyces cerevisiae as a model organism to investigate the anti-aging properties of phycocyanin from A. platensis. Our results show that phycocyanin has a powerful anti-aging effect, greatly extending the chronological life span of yeast cells in a dose-dependent way, as the effect was also pronounced when cells were grown in SD medium under calorie restriction conditions (0.2% glucose). Both ROS and accumulation of dead cells were followed by staining chronologically aged cells with dihydrorhodamine 123 (DHR123) and propidium iodide (PI). Interestingly, we found that most of the aged phycocyanin-treated cells, which were unable to form colonies, were actually ROS+/PI–. Finally, we show that the moment in which phycocyanin is added to the culture does not substantially influence its effectiveness in counteracting chronological aging. Full article

(This article belongs to the Special Issue Stress Response Research: Yeast as Models 2.0)

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