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Advances in Head and Neck and Skin Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1288

Special Issue Editors


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Guest Editor
Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy
Interests: Head and Neck cancer and skin cancer

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Guest Editor
Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Interests: melanoma; dermatology; dermatoscopy; hidradenitis suppurativa; acne
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Guest Editor
Department of Oncology, University of Torino, 10125 Torino, Italy
Interests: radiation oncology; head and neck cancer; non melanoma skin cancer; stereotassic radiotherapy; oligometastases

Special Issue Information

Dear Colleagues,

Immunotherapy and a combination of old and new treatments have revolutionized the scenario of head and neck and skin cancers. The aging of populations justifies the growing number of patients who deserve a multidisciplinary approach. In head and neck cancer, despite chemoradiotherapy, about 50% of patients with locally advanced disease will recur in 5 years, and in recurrent metastatic disease, the prognosis, even if patients are treated with immunotherapy or chemo-immunotherapy is dismal, only 20% of responders benefit from these new treatments. Melanoma is the neoplasm that has paved the way for innovations in molecular biology and immunotherapy, and the field of study is always in turmoil to further increase the outcomes. Basal cell carcinoma (BCC) is the most frequent among nonmelanoma skin carcinomas. Hedgehog inhibitors have changed the scenario in BCC, and second-line treatment is now available for incompliant or progressive disease. In squamous cell carcinoma, an increasing number of elderly is now a candidate for immunotherapy with Cemiplimab. Interestingly, new combinations with anti-epidermal growth factor receptor antibodies and other tyrosine kinase inhibitors are ongoing, and promising results are awaited. Most nonmelanoma skin cancer affects the head and neck region.

Continuing education and a very compact multidisciplinary group are essential to ensure high levels of procedures and cures. Every physician should contribute with the last significant advance in their field.

The scope of this Special Issue is to collect recent advances in head and neck cancer and skin cancer treatments.

Dr. Nerina Denaro
Prof. Dr. Gianluca Nazzaro
Dr. Iorio Giuseppe Carlo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck cancer
  • melanoma
  • nonmelanoma skin cancer
  • immunotherapy
  • tumor microenvironment

Published Papers (1 paper)

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Review

14 pages, 530 KiB  
Review
A Multidisciplinary Approach to Patients with Psoriasis and a History of Malignancies or On-Treatment for Solid Tumors: A Narrative Literature Review
by Nerina Denaro, Gianluca Nazzaro, Giulia Murgia, Federica Scarfì, Carolina Cauchi, Carlo Giovanni Carrera, Angelo Cattaneo, Cinzia Solinas, Mario Scartozzi, Angelo Valerio Marzano, Ornella Garrone and Emanuela Passoni
Int. J. Mol. Sci. 2023, 24(24), 17540; https://doi.org/10.3390/ijms242417540 - 16 Dec 2023
Cited by 1 | Viewed by 996
Abstract
Psoriasis is a chronic immune-mediated disease that is linked to an increased risk of cancer. Although numerous studies have explored whether neoplasms are concurrent conditions or are induced by psoriasis, a definitive definition remains elusive. In this study, we conducted a comprehensive narrative [...] Read more.
Psoriasis is a chronic immune-mediated disease that is linked to an increased risk of cancer. Although numerous studies have explored whether neoplasms are concurrent conditions or are induced by psoriasis, a definitive definition remains elusive. In this study, we conducted a comprehensive narrative literature review to offer practical guidance to oncologists and dermatologists regarding the initiation and discontinuation of biologics for psoriasis. The findings indicate that a customized approach is recommended for each patient, and that a history of malignancies does not constitute an absolute contraindication for biologics. Growing evidence supports the treatment of selected patients, emphasizing a nuanced assessment of benefits and risks. There is a lack of data specifying a safe timeframe to initiate biologics following a neoplasm diagnosis due to influences from cancer-related and patient-specific characteristics impacting prognosis. Some patients may continue anti-psoriasis therapy during cancer treatments. Enhanced comprehension of the biological mechanisms in cancer progression and the immune microenvironment of psoriasis holds promise for refining therapeutic strategies. In conclusion, a personalized treatment approach necessitates collaboration between oncologists and dermatologists, considering factors such as cancer prognosis, psoriasis clinical manifestations, patient characteristics, and preferences when making treatment decisions. Full article
(This article belongs to the Special Issue Advances in Head and Neck and Skin Cancer)
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