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COVID-19 Pandemic: Therapeutic Strategies and Vaccines 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (25 April 2024) | Viewed by 1959

Special Issue Editor

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, “COVID-19 Pandemic: Therapeutic Strategies and Vaccines”. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly pathogenic and transmissible virus. The amount of knowledge gathered so far on the subject is impressive. It is now clear that adequately strong immunity is the best weapon against COVID-19. The various SARS-CoV-2 variants have contributed to the extent of infection and spread of the virus, and may play a role in the immune response either acquired or induced by vaccination. In addition, host genetics and gene expression regulation have been shown to be key in the response to the infection.

Various antiviral drugs and immune-modulating methods have been evaluated. So far, no particular therapeutic option has not been approved among the variety of treatments that have been studied for COVID-19, including oxygen therapy, corticosteroids, antiviral agents, targeted therapy, and vaccines, all of which have diverse effects and outcomes in each patient. According to the findings of in vitro and in vivo studies, some novel approaches, such as gene editing, cell-based therapy, and immunotherapy, may have significant potential in the treatment of COVID-19.

We welcome submissions of cutting-edge primary research, reviews, and commentaries, with a focus on different strategies for treatment and prevention against COVID-19.

Dr. Mariarosaria Boccellino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • COVID-19
  • vaccines
  • virus

Published Papers (1 paper)

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Review

42 pages, 2137 KiB  
Review
An Update on SARS-CoV-2 Clinical Trial Results—What We Can Learn for the Next Pandemic
by Benediktus Yohan Arman, Juliane Brun, Michelle L. Hill, Nicole Zitzmann and Annette von Delft
Int. J. Mol. Sci. 2024, 25(1), 354; https://doi.org/10.3390/ijms25010354 - 26 Dec 2023
Viewed by 1565
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has claimed over 7 million lives worldwide, providing a stark reminder of the importance of pandemic preparedness. Due to the lack of approved antiviral drugs effective against coronaviruses at the start of the pandemic, the world largely [...] Read more.
The coronavirus disease 2019 (COVID-19) pandemic has claimed over 7 million lives worldwide, providing a stark reminder of the importance of pandemic preparedness. Due to the lack of approved antiviral drugs effective against coronaviruses at the start of the pandemic, the world largely relied on repurposed efforts. Here, we summarise results from randomised controlled trials to date, as well as selected in vitro data of directly acting antivirals, host-targeting antivirals, and immunomodulatory drugs. Overall, repurposing efforts evaluating directly acting antivirals targeting other viral families were largely unsuccessful, whereas several immunomodulatory drugs led to clinical improvement in hospitalised patients with severe disease. In addition, accelerated drug discovery efforts during the pandemic progressed to multiple novel directly acting antivirals with clinical efficacy, including small molecule inhibitors and monoclonal antibodies. We argue that large-scale investment is required to prepare for future pandemics; both to develop an arsenal of broad-spectrum antivirals beyond coronaviruses and build worldwide clinical trial networks that can be rapidly utilised. Full article
(This article belongs to the Special Issue COVID-19 Pandemic: Therapeutic Strategies and Vaccines 2.0)
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