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Health Properties of Plant Bioactive Compounds: Immune, Antioxidant and Metabolic Effects 2.0

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 3276

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Dr. Antonio Carrillo-Vico

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Guest Editor

1. Institute of Biomedicine of Seville (IBiS), University of Seville, CSIC, 41013 Sevilla, Spain
2. Department of Medical Biochemistry and Molecular Biology, University of Seville, 41013 Sevilla, Spain
Interests: bioactive compounds; immunomodulation; oxidative stress; melatonin; multiple sclerosis
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Dr. Ivan Cruz-Chamorro

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Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, Universidad de Sevilla, 41009 Seville, Spain
Interests: functional foods; protein hydrolysate; antioxidant; immunomodulation; natural extracts; biopeptides; lupine; hemp
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last two decades, plant bioactive compounds have been reported to confer beneficial health effects, such as antioxidant, anti-inflammatory, anti-cancer, anti-hypertensive, hypoglycemic, lipid-lowering, and metabolic effects, among others.

All these effects were described from in vitro and in vivo studies in which different plant-derived compounds, including proteins, protein hydrolysates, specific peptides, polyphenols, oils, juices, flowers, seeds, etc., were used.

Currently, there is a big increase in modern society lifestyle-related diseases, which are characterized by the loss of control of the antioxidant and immune systems, as well as metabolic processes. Thus, plant bioactive compounds that are capable of modifying or controlling these factors could be suitable candidates to develop plant-based functional food in health promotion.

It is also noteworthy the increasing attention to the environmental impact of the modern animal agriculture. Thus, the identification bioactive compounds from natural vegetable sources is an interesting strategy not only for replacing animal proteins with plant proteins, which is a central issue for health, but also for reducing the environmental impact of animal agriculture.

Therefore, this Special Issue of International Journal of Molecular Sciences, entitled “Health Properties of Plant Bioactive Compounds: Immune, Antioxidant and Metabolic Effects 2.0”, welcomes the submission of original articles or reviews that can improve the knowledge about the beneficial health effects of vegetable compounds, such as immunomodulation, antioxidant, and metabolic regulation.

Dr. Antonio Carrillo-Vico
Dr. Ivan Cruz-Chamorro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

oxidative stress
inflammation
metabolism
plant bioactive compounds
functional food
nutraceuticals
natural extracts
human health
nutrition
metabolic syndrome
chronic diseases
cardiovascular diseases
cancer

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16 pages, 3492 KiB

Open AccessArticle

Tiliroside Combined with Anti-MUC1 Monoclonal Antibody as Promising Anti-Cancer Strategy in AGS Cancer Cells

by Iwona Radziejewska, Katarzyna Supruniuk, Katarzyna Jakimiuk, Michał Tomczyk, Anna Bielawska and Anna Galicka

Int. J. Mol. Sci. 2023, 24(17), 13036; https://doi.org/10.3390/ijms241713036 - 22 Aug 2023

Cited by 1 | Viewed by 1154

Abstract

Specific changes in mucin-type O-glycosylation are common for many cancers, including gastric ones. The most typical alterations include incomplete synthesis of glycan structures, enhanced expression of truncated O-glycans (Tn, T antigens and their sialylated forms), and overexpression of fucosylation. Such altered glycans influence many cellular activities promoting cancer development. Tiliroside is a glycosidic dietary flavonoid with pharmacological properties, including anti-cancer. In this study, we aim to assess the effect of the combined action of anti-MUC1 and tiliroside on some cancer-related factors in AGS gastric cancer cells. Cancer cells were treated with 40, 80, and 160 µM tiliroside, 5 µg/mL anti-MUC1, and flavonoid together with mAb. Real-Time PCR, ELISA, and Western blotting were applied to examine MUC1 expression, specific, tumor-associated antigens, enzymes taking part in their formation, Gal-3, Akt, and NF-κB. MUC1 expression was significantly reduced by mAb action. The combined action of anti-MUC1 and tiliroside was more effective in comparison with monotherapy in the case of C1GalT1, ST3GalT1, FUT4, Gal-3, NF-κB, Akt mRNAs, and Tn antigen, as well as sialyl T antigen expression. The results of our study indicate that applied combined therapy may be a promising anti-gastric cancer strategy. Full article

(This article belongs to the Special Issue Health Properties of Plant Bioactive Compounds: Immune, Antioxidant and Metabolic Effects 2.0)

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20 pages, 4255 KiB

Open AccessArticle

Molecular Characterization of Prunus lusitanica L. Fruit Extracts and Their Health-Promoting Potential in Inflammation, Diabetes, and Neurodegenerative Diseases

by Ana Abraão, Carlos Martins-Gomes, Raúl Domínguez-Perles, Ana Barros and Amélia M. Silva

Int. J. Mol. Sci. 2023, 24(10), 8830; https://doi.org/10.3390/ijms24108830 - 16 May 2023

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Abstract

Prunus lusitanica L. is a shrub belonging to the genus Prunus L. (Rosaceae family) that produces small fruits with none known application. Thus, the aim of this study was to determine the phenolic profile and some health-promoting activities of hydroethanolic (HE) extracts obtained from P. lusitanica fruits, harvested from three different locations. Qualitative and quantitative analysis of extracts was performed using HPLC/DAD-ESI-MS and antioxidant activity was assessed by in vitro methods. Antiproliferative/cytotoxic activity was determined on Caco-2, HepG2, and RAW 264.7 cells, anti-inflammatory activity was assessed using lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, and the antidiabetic, antiaging, and neurobiological action of extracts was determined in vitro by assessing their inhibitory effect against the activity of α-amylase, α-glucosidase, elastase, tyrosinase, and acetylcholinesterase (AChE). Results showed that P. lusitanica fruit HE extracts from the three different locations showed identical phytochemical profile and bioactivities, although small differences were observed regarding the quantities of some compounds. Extracts of P. lusitanica fruits contain high levels in total phenolic compounds, namely, hydroxycinnamic acids, as well as flavan-3-ols and anthocyanins, primarily cyanidin-3-(6-trans-p-coumaroyl)glucoside. P. lusitanica fruit extracts have a low cytotoxic/antiproliferative effect, with the lowest IC₅₀ value obtained in HepG2 cells (352.6 ± 10.0 μg/mL, at 48 h exposure), but high anti-inflammatory activity (50–60% NO release inhibition, at 100 μg/mL extract) and neuroprotective potential (35–39% AChE inhibition, at 1 mg/mL), and moderate antiaging (9–15% tyrosinase inhibition, at 1 mg/mL) and antidiabetic (9–15% α-glucosidase inhibition, at 1 mg/mL) effects. The bioactive molecules present in the fruits of P. lusitanica deserve to be further explored for the development of new drugs of interest to the pharmaceutical and cosmetic industry. Full article

(This article belongs to the Special Issue Health Properties of Plant Bioactive Compounds: Immune, Antioxidant and Metabolic Effects 2.0)

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