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Molecular Advances in Platelets

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 2477

Special Issue Editor


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Guest Editor
Hematology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain
Interests: wAIHA; immune thrombocytopenia; ITP; multiple myeloma; chemotherapy; acute myeloid leukaemia; leukaemia
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Special Issue Information

Dear Colleagues,

Immune thrombocytopenia (ITP) is an autoimmune disorder characterised by low platelet counts (<100 × 109/L), whose diagnosis is based on first discarding other conditions that could be associated with thrombocytopenia.

In recent years, new discoveries have been made regarding ITP diagnosis and treatment. Thus, although ITP is still recognized on the basis of an exclusion diagnosis, new lab tools such as those proposed by molecular biology studies have acquired increasing importance. Furthermore, new drugs such as thrombopoietin (TPO) analogues and spleen tyrosine kinase (Syk) inhibitors have been developed and extensively used in recent years.

Given the growing interest in ITP and the molecular basis of this disease, the International Journal of Molecular Sciences is launching this Special Issue.

We encourage you and your co-workers to submit articles reporting on ITP. Reviews or original articles dealing with different aspects of molecular biology and ITP: usefulness of molecular techniques for diagnosis, genetic susceptibility to develop ITP, refractoriness to treatment with current drugs used for this disease, usefulness of molecular biology as predictors of response or as markers of interruption of TPO-RAs are just some of the possible targets of this Special Issue.

In addition, we warmly invite you to submit articles reporting on less frequent types of ITP, e.g., ITP secondary to autoimmune or infectious diseases and lymphoproliferative disorders, drug-induced ITP, etc., and their potential molecular insights.

We look forward to receiving your contributions and realizing an interest in completing this Special Issue!

Dr. Tomas Jose Gonzalez-Lopez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • platelets
  • immune thrombocytopenia, diagnosis, treatment
  • thrombopoietin
  • thrombopoietin receptor agonists
  • immunosuppression
  • eltrombopag
  • romiplostim
  • rituximab

Published Papers (1 paper)

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Review

20 pages, 1511 KiB  
Review
Current Understanding of Immune Thrombocytopenia: A Review of Pathogenesis and Treatment Options
by Alina Mititelu, Minodora-Cezarina Onisâi, Adrian Roșca and Ana Maria Vlădăreanu
Int. J. Mol. Sci. 2024, 25(4), 2163; https://doi.org/10.3390/ijms25042163 - 10 Feb 2024
Viewed by 1981
Abstract
The management of immune thrombocytopenia (ITP) and the prediction of patient response to therapy still represent a significant and constant challenge in hematology. ITP is a heterogeneous disease with an unpredictable evolution. Although the pathogenesis of ITP is currently better known and its [...] Read more.
The management of immune thrombocytopenia (ITP) and the prediction of patient response to therapy still represent a significant and constant challenge in hematology. ITP is a heterogeneous disease with an unpredictable evolution. Although the pathogenesis of ITP is currently better known and its etiology has been extensively studied, up to 75% of adult patients with ITP may develop chronicity, which represents a significant burden on patients’ quality of life. A major risk of ITP is bleeding, but knowledge on the exact relationship between the degree of thrombocytopenia and bleeding symptoms, especially at a lower platelet count, is lacking. The actual management of ITP is based on immune suppression (corticosteroids and intravenous immunoglobulins), or the use of thrombopoietin receptor agonists (TPO-RAs), rituximab, or spleen tyrosine kinase (Syk) inhibitors. A better understanding of the underlying pathology has facilitated the development of a number of new targeted therapies (Bruton’s tyrosine kinase inhibitors, neonatal Fc receptors, strategies targeting B and plasma cells, strategies targeting T cells, complement inhibitors, and newer TPO-RAs for improving megakaryopoiesis), which seem to be highly effective and well tolerated and result in a significant improvement in patients’ quality of life. The disadvantage is that there is a lack of knowledge of the predictive factors of response to treatments, which would help in the development of an optimized treatment algorithm for selected patients. Full article
(This article belongs to the Special Issue Molecular Advances in Platelets)
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