Molecular Research on Epigenetic Modifications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 5051
Special Issue Editors
2. CEINGE Biotecnologie Avanzate, 80145 Naples, Italy
Interests: epigenetics; HDAC; HDAC inhibitors; human mesenchymal stem cells (hMSC); amniocytes and bone regeneration
2. CEINGE Biotecnologie Avanzate, 80145 Naples, Italy
Interests: DNA methylation; brain tumors; stem cells
2. CEINGE Biotecnologie Avanzate, 80145 Naples, Italy
Interests: DNA methylation; brain tumors; cell cycle
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Epigenetics generally refers to heritable changes in gene expression and in the organization of chromatin that are not caused by alterations in the DNA sequence. The complexity of the mammalian genome is regulated by heritable epigenetic mechanisms, which are the basis of cell differentiation, development and homeostasis. These mechanisms help to determine cell fate and phenotype and must be stably maintained during cell division to preserve their identity, as well as to react to intrinsic signals during development or those originating from external environmental factors. Aberrations in epigenetic modifications are essential protagonists in the genesis and progression of various diseases, including cancer, assuming a predominant role in the understanding and treatment of these diseases.
These aberrations can lead to inappropriate expression or activation of transcription factors associated with oncogenesis and/or inactivation or inability to express tumor suppressor genes. The molecular basis of epigenetics is very complex and the discovery of new molecular targets for new and more powerful drugs has led to the search for small modulating molecules that can revert an increasing number of diseases.
Led by Dr. Marco Miceli and assisted by our co-Guest editors, Dr. Mariella Cuomo and Dr. Rosa Della Monica, this Special Issue of IJMS, “Molecular Research on Epigenetic Modifications”, welcomes researchers to contribute to the scientific advancement of this promising new discipline.
Dr. Marco Miceli
Dr. Mariella Cuomo
Dr. Rosa Della Monica
Guest Editors
Manuscript Submission Information
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Keywords
- epigenetic modifications
- chromatin remodeling
- transcription factors
- RNA modification
- histones
- methylation
- diseases
- epigenetic drugs development
