ijms-logo

Journal Browser

Journal Browser

Molecular Research on Epigenetic Modifications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 5271

Special Issue Editors


E-Mail Website
Guest Editor
1. Department of Neuroscience and Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, 80131 Naples, Italy
2. CEINGE Biotecnologie Avanzate, 80145 Naples, Italy
Interests: epigenetics; HDAC; HDAC inhibitors; human mesenchymal stem cells (hMSC); amniocytes and bone regeneration

E-Mail Website
Guest Editor
1. Department of Neuroscience and Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, 80131 Naples, Italy
2. CEINGE Biotecnologie Avanzate, 80145 Naples, Italy
Interests: DNA methylation; brain tumors; stem cells

E-Mail Website
Guest Editor
1. Department of Neuroscience and Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, 80131 Naples, Italy
2. CEINGE Biotecnologie Avanzate, 80145 Naples, Italy
Interests: DNA methylation; brain tumors; cell cycle
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Epigenetics generally refers to heritable changes in gene expression and in the organization of chromatin that are not caused by alterations in the DNA sequence. The complexity of the mammalian genome is regulated by heritable epigenetic mechanisms, which are the basis of cell differentiation, development and homeostasis. These mechanisms help to determine cell fate and phenotype and must be stably maintained during cell division to preserve their identity, as well as to react to intrinsic signals during development or those originating from external environmental factors. Aberrations in epigenetic modifications are essential protagonists in the genesis and progression of various diseases, including cancer, assuming a predominant role in the understanding and treatment of these diseases.

These aberrations can lead to inappropriate expression or activation of transcription factors associated with oncogenesis and/or inactivation or inability to express tumor suppressor genes. The molecular basis of epigenetics is very complex and the discovery of new molecular targets for new and more powerful drugs has led to the search for small modulating molecules that can revert an increasing number of diseases.

Led by Dr. Marco Miceli and assisted by our co-Guest editors, Dr. Mariella Cuomo and Dr. Rosa Della Monica, this Special Issue of IJMS, “Molecular Research on Epigenetic Modifications”, welcomes researchers to contribute to the scientific advancement of this promising new discipline.

Dr. Marco Miceli
Dr. Mariella Cuomo
Dr. Rosa Della Monica
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epigenetic modifications
  • chromatin remodeling
  • transcription factors
  • RNA modification
  • histones
  • methylation
  • diseases
  • epigenetic drugs development

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Review

26 pages, 2707 KiB  
Review
Basic Pathogenic Mechanisms and Epigenetic Players Promoted by Extracellular Vesicles in Vascular Damage
by Concetta Schiano, Carolina Balbi, Filomena de Nigris and Claudio Napoli
Int. J. Mol. Sci. 2023, 24(8), 7509; https://doi.org/10.3390/ijms24087509 - 19 Apr 2023
Cited by 3 | Viewed by 1565
Abstract
Both progression from the early pathogenic events to clinically manifest cardiovascular diseases (CVD) and cancer impact the integrity of the vascular system. Pathological vascular modifications are affected by interplay between endothelial cells and their microenvironment. Soluble factors, extracellular matrix molecules and extracellular vesicles [...] Read more.
Both progression from the early pathogenic events to clinically manifest cardiovascular diseases (CVD) and cancer impact the integrity of the vascular system. Pathological vascular modifications are affected by interplay between endothelial cells and their microenvironment. Soluble factors, extracellular matrix molecules and extracellular vesicles (EVs) are emerging determinants of this network that trigger specific signals in target cells. EVs have gained attention as package of molecules with epigenetic reversible activity causing functional vascular changes, but their mechanisms are not well understood. Valuable insights have been provided by recent clinical studies, including the investigation of EVs as potential biomarkers of these diseases. In this paper, we review the role and the mechanism of exosomal epigenetic molecules during the vascular remodeling in coronary heart disease as well as in cancer-associated neoangiogenesis. Full article
(This article belongs to the Special Issue Molecular Research on Epigenetic Modifications)
Show Figures

Figure 1

15 pages, 1644 KiB  
Review
Methyl Donor Micronutrients: A Potential Dietary Epigenetic Target in Systemic Lupus Erythematosus Patients
by Karen Pesqueda-Cendejas, Bertha Campos-López, Paulina E. Mora-García, José M. Moreno-Ortiz and Ulises De la Cruz-Mosso
Int. J. Mol. Sci. 2023, 24(4), 3171; https://doi.org/10.3390/ijms24043171 - 6 Feb 2023
Cited by 2 | Viewed by 2836
Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by an aberrant immune response and persistent inflammation. Its pathogenesis remains unknown; however, a complex interaction between environmental, genetic, and epigenetic factors has been suggested to cause disease onset. Several studies have demonstrated [...] Read more.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by an aberrant immune response and persistent inflammation. Its pathogenesis remains unknown; however, a complex interaction between environmental, genetic, and epigenetic factors has been suggested to cause disease onset. Several studies have demonstrated that epigenetic alterations, such as DNA hypomethylation, miRNA overexpression, and altered histone acetylation, may contribute to SLE onset and the disease’s clinical manifestations. Epigenetic changes, especially methylation patterns, are modifiable and susceptible to environmental factors such as diet. It is well known that methyl donor nutrients, such as folate, methionine, choline, and some B vitamins, play a relevant role in DNA methylation by participating as methyl donors or coenzymes in one-carbon metabolism. Based on this knowledge, this critical literature review aimed to integrate the evidence in animal models and humans regarding the role of nutrients in epigenetic homeostasis and their impact on immune system regulation to suggest a potential epigenetic diet that could serve as adjuvant therapy in SLE. Full article
(This article belongs to the Special Issue Molecular Research on Epigenetic Modifications)
Show Figures

Figure 1

Back to TopTop