Special Issue "Synaptic Vulnerability: From Biological to Therapeutic Point of View"
Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 5252
Interests: LRRK2; Parkinson’s disease; autophagy; synapse; alpha-synuclein
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The synapse plays a critical role in all phases of neuronal life. Neurotransmission, synaptic plasticity, and neuron development are crucial for synaptic maintenance and vesicle turnover, contributing to synapse organization, the mobilization of synaptic vesicles, and neurotransmitter release.
Events underlying synapse formation, plasticity, and neurotransmission are thus essential and synaptic plasticity changes, neurotransmission disruption, synaptic protein alterations, receptor dysregulation as well as mitochondrial alterations may increase synaptic vulnerability, inhibiting the proper turnover and clustering of synaptic vesicles and ultimately leading to neuronal death. Neurons are particularly vulnerable to internal and external factors, which may cause injury followed by neurodegeneration. Different insults may increase synaptic vulnerability, disrupting homeostatic equilibrium and resulting in the progression of the pathology.
This Special Issue aims to cover the biological aspects of the synapse, from neuronal development to mature synapse. Descriptions of molecular mechanisms are welcome to underline synaptic physiological homeostasis as well as the disruption of synaptic machinery and the onset of neurodegenerative disorders.
Manuscripts describing recent developments of treatments for delaying or preventing neuronal injury are essential to understanding the novel therapeutic approaches underpinning the molecular events of synaptic injury and vulnerability and delaying the onset or progression of neuronal loss.
Dr. Mattia Volta
Dr. Gaia Faustini
Manuscript Submission Information
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- synaptic vesicles
- vesicle turnover
- neurotransmitter release
- mitochondrial deficit
- synaptic homeostasis
- cognitive deficit
- Parkinson’s disease
- Alzheimer’s disease