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The Role of Non-coding RNAs Involved in Cardiovascular Diseases and Cellular Communication

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (29 September 2023) | Viewed by 9615

Special Issue Editors

Dr. José Luis García-Giménez

E-Mail Website
Guest Editor
1. Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia, Valencia, Spain
2. FIHCUV-INCLIVA, 46010 Valencia, Spain
3. Rare Diseases Biomedical Research Networking Centre (CIBERER), The Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain
4. EpiDisease, S.L., 46980 Valencia, Spain
Interests: rare diseases; epigenetics; molecular biomarkers; DNA methylation; microRNA; histones; mass spectrometry and next generation sequencing
Special Issues, Collections and Topics in MDPI journals
Dr. Montserrat Climent Salarich

E-Mail Website
Guest Editor
Humanitas Clinical and Research Center—IRCCS, Via Manzoni 56, 20089 Rozzano, MI, Italy
Interests: endothelial cells; smooth muscle cells; vascular diseases; vascular remodeling; atherosclerosis; non-coding RNAs

Special Issue Information

Dear Colleagues,

We are pleased to communicate the opening for submission to the Special Issue “The role of non-coding RNAs in cardiovascular diseases and cellular communication” in the International Journal of Molecular Sciences.

Non-coding RNAs (ncRNAs) are well recognized as key regulators of different biological processes controlling several pathological conditions, including cardiovascular diseases. Among small ncRNAs, microRNAs (miRNAs) are capable of regulating many targets, having a direct implication in a wide range of pathways. Long ncRNAs can in turn regulate miRNAs expression. In recent years, ncRNAs have been shown to act at both the intracellular level, directly or indirectly regulating gene expression within the same cell, and extracellular level, being secreted or transported in different ways to other cells. Thus, they are considered important communication molecules. All these features make ncRNAs great candidates as biomarkers and potential therapeutic tools.

We are delighted to encourage contribution to the Special Issue by submitting original research articles or reviews which will add new knowledge to the field.

Dr. José Luis García-Giménez
Dr. Montserrat Climent Salarich
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ncRNAs
  • long non-coding RNAs
  • miRNAs
  • cardiovascular diseases
  • cellular communication
  • exososomes
  • multivescicular bodies

Published Papers (6 papers)

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Research

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21 pages, 2171 KiB  
Article
A Meta-Analysis Approach to Gene Regulatory Network Inference Identifies Key Regulators of Cardiovascular Diseases
by Gerardo Pepe, Romina Appierdo, Gabriele Ausiello, Manuela Helmer-Citterich and Pier Federico Gherardini
Int. J. Mol. Sci. 2024, 25(8), 4224; https://doi.org/10.3390/ijms25084224 - 11 Apr 2024
Viewed by 531
Abstract
Cardiovascular diseases (CVDs) represent a major concern for global health, whose mechanistic understanding is complicated by a complex interplay between genetic predisposition and environmental factors. Specifically, heart failure (HF), encompassing dilated cardiomyopathy (DC), ischemic cardiomyopathy (ICM), and hypertrophic cardiomyopathy (HCM), is a topic [...] Read more.
Cardiovascular diseases (CVDs) represent a major concern for global health, whose mechanistic understanding is complicated by a complex interplay between genetic predisposition and environmental factors. Specifically, heart failure (HF), encompassing dilated cardiomyopathy (DC), ischemic cardiomyopathy (ICM), and hypertrophic cardiomyopathy (HCM), is a topic of substantial interest in basic and clinical research. Here, we used a Partial Correlation Coefficient-based algorithm (PCC) within the context of a meta-analysis framework to construct a Gene Regulatory Network (GRN) that identifies key regulators whose activity is perturbed in Heart Failure. By integrating data from multiple independent studies, our approach unveiled crucial regulatory associations between transcription factors (TFs) and structural genes, emphasizing their pivotal roles in regulating metabolic pathways, such as fatty acid metabolism, oxidative stress response, epithelial-to-mesenchymal transition, and coagulation. In addition to known associations, our analysis also identified novel regulators, including the identification of TFs FPM315 and OVOL2, which are implicated in dilated cardiomyopathies, and TEAD1 and TEAD2 in both dilated and ischemic cardiomyopathies. Moreover, we uncovered alterations in adipogenesis and oxidative phosphorylation pathways in hypertrophic cardiomyopathy and discovered a role for IL2 STAT5 signaling in heart failure. Our findings underscore the importance of TF activity in the initiation and progression of cardiac disease, highlighting their potential as pharmacological targets. Full article
(This article belongs to the Special Issue The Role of Non-coding RNAs Involved in Cardiovascular Diseases and Cellular Communication)
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17 pages, 5960 KiB  
Article
Elevated Levels of Circulating lncRNAs LIPCAR and MALAT1 Predict an Unfavorable Outcome in Acute Coronary Syndrome Patients
by Teodora Barbalata, Loredan S. Niculescu, Camelia S. Stancu, Florence Pinet and Anca V. Sima
Int. J. Mol. Sci. 2023, 24(15), 12076; https://doi.org/10.3390/ijms241512076 - 28 Jul 2023
Cited by 1 | Viewed by 933
Abstract
Coronary artery disease (CAD) is a leading cause of mortality worldwide. In this study, we aimed to assess the potential of plasma long non-coding RNAs (lncRNAs) LIPCAR and MALAT1 and microRNAs (miRNAs) miR-142-3p and miR-155-5p to discriminate unstable CAD patients from stable ones. [...] Read more.
Coronary artery disease (CAD) is a leading cause of mortality worldwide. In this study, we aimed to assess the potential of plasma long non-coding RNAs (lncRNAs) LIPCAR and MALAT1 and microRNAs (miRNAs) miR-142-3p and miR-155-5p to discriminate unstable CAD patients from stable ones. 23 stable angina (SA), 21 unstable angina (UA), and 50 ST-segment elevation myocardial infarction (STEMI) patients were enrolled; their plasma was collected. ncRNA plasma levels were evaluated using RT-qPCR. All measured ncRNA levels were significantly increased in UA patients’ plasma compared to SA patients’ plasma and in STEMI-with major adverse cardiovascular event (MACE) patients’ plasma vs. STEMI-without MACE patients’ plasma. ROC analysis showed that increased levels of LIPCAR and MALAT1 were associated with UA, and the prognostic model improved with the addition of miR-155-5p levels. The assessed lncRNAs discriminated between hyperglycemic (HG) and normoglycemic (NG) UA patients, and they were associated with MACE incidence in STEMI patients; this prediction was improved by the addition of miR-142-3p levels to the ROC multivariate model. We propose LIPCAR and MALAT1 as effective diagnostic markers for vulnerable CAD, their association with HG in UA patients, and as robust predictors for unfavorable evolution of STEMI patients. Full article
(This article belongs to the Special Issue The Role of Non-coding RNAs Involved in Cardiovascular Diseases and Cellular Communication)
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Review

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17 pages, 1996 KiB  
Review
Advances in Intercellular Communication Mediated by Exosomal ncRNAs in Cardiovascular Disease
by Xiaoyan Zhang, Shengjie Sun, Gang Ren, Wujun Liu and Hong Chen
Int. J. Mol. Sci. 2023, 24(22), 16197; https://doi.org/10.3390/ijms242216197 - 11 Nov 2023
Cited by 1 | Viewed by 1390
Abstract
Cardiovascular diseases are a leading cause of worldwide mortality, and exosomes have recently gained attention as key mediators of intercellular communication in these diseases. Exosomes are double-layered lipid vesicles that can carry biomolecules such as miRNAs, lncRNAs, and circRNAs, and the content of [...] Read more.
Cardiovascular diseases are a leading cause of worldwide mortality, and exosomes have recently gained attention as key mediators of intercellular communication in these diseases. Exosomes are double-layered lipid vesicles that can carry biomolecules such as miRNAs, lncRNAs, and circRNAs, and the content of exosomes is dependent on the cell they originated from. They can be involved in the pathophysiological processes of cardiovascular diseases and hold potential as diagnostic and monitoring tools. Exosomes mediate intercellular communication, stimulate or inhibit the activity of target cells, and affect myocardial hypertrophy, injury and infarction, ventricular remodeling, angiogenesis, and atherosclerosis. Exosomes can be released from various types of cells, including endothelial cells, smooth muscle cells, cardiomyocytes, fibroblasts, platelets, adipocytes, immune cells, and stem cells. In this review, we highlight the communication between different cell-derived exosomes and cardiovascular cells, with a focus on the roles of RNAs. This provides new insights for further exploring targeted therapies in the clinical management of cardiovascular diseases. Full article
(This article belongs to the Special Issue The Role of Non-coding RNAs Involved in Cardiovascular Diseases and Cellular Communication)
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22 pages, 3880 KiB  
Review
The Role of Long Non-Coding RNAs in Cardiovascular Diseases
by Linh T. T. Le and Chan X. T. Nhu
Int. J. Mol. Sci. 2023, 24(18), 13805; https://doi.org/10.3390/ijms241813805 - 7 Sep 2023
Cited by 4 | Viewed by 1264
Abstract
Long non-coding RNAs (lncRNAs) are non-coding RNA molecules longer than 200 nucleotides that regulate gene expression at the transcriptional, post-transcriptional, and translational levels. Abnormal expression of lncRNAs has been identified in many human diseases. Future improvements in diagnostic, prognostic, and therapeutic techniques will [...] Read more.
Long non-coding RNAs (lncRNAs) are non-coding RNA molecules longer than 200 nucleotides that regulate gene expression at the transcriptional, post-transcriptional, and translational levels. Abnormal expression of lncRNAs has been identified in many human diseases. Future improvements in diagnostic, prognostic, and therapeutic techniques will be facilitated by a deeper understanding of disease etiology. Cardiovascular diseases (CVDs) are the main cause of death globally. Cardiac development involves lncRNAs, and their abnormalities are linked to many CVDs. This review examines the relationship and function of lncRNA in a variety of CVDs, including atherosclerosis, myocardial infarction, myocardial hypertrophy, and heart failure. Therein, the potential utilization of lncRNAs in clinical diagnostic, prognostic, and therapeutic applications will also be discussed. Full article
(This article belongs to the Special Issue The Role of Non-coding RNAs Involved in Cardiovascular Diseases and Cellular Communication)
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19 pages, 1410 KiB  
Review
The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation
by Irene Cánovas-Cervera, Elena Nacher-Sendra, Rebeca Osca-Verdegal, Enric Dolz-Andrés, Jesús Beltrán-García, María Rodríguez-Gimillo, Carolina Ferrando-Sánchez, Nieves Carbonell and José Luis García-Giménez
Int. J. Mol. Sci. 2023, 24(3), 2582; https://doi.org/10.3390/ijms24032582 - 30 Jan 2023
Cited by 2 | Viewed by 1987
Abstract
Disseminated Intravascular Coagulation (DIC) is a type of tissue and organ dysregulation in sepsis, due mainly to the effect of the inflammation on the coagulation system. Unfortunately, the underlying molecular mechanisms that lead to this disorder are not fully understood. Moreover, current biomarkers [...] Read more.
Disseminated Intravascular Coagulation (DIC) is a type of tissue and organ dysregulation in sepsis, due mainly to the effect of the inflammation on the coagulation system. Unfortunately, the underlying molecular mechanisms that lead to this disorder are not fully understood. Moreover, current biomarkers for DIC, including biological and clinical parameters, generally provide a poor diagnosis and prognosis. In recent years, non-coding RNAs have been studied as promising and robust biomarkers for a variety of diseases. Thus, their potential in the diagnosis and prognosis of DIC should be further studied. Specifically, the relationship between the coagulation cascade and non-coding RNAs should be established. In this review, microRNAs, long non-coding RNAs, and circular RNAs are studied in relation to DIC. Specifically, the axis between these non-coding RNAs and the corresponding affected pathway has been identified, including inflammation, alteration of the coagulation cascade, and endothelial damage. The main affected pathway identified is PI3K/AKT/mTOR axis, where several ncRNAs participate in its regulation, including miR-122-5p which is sponged by circ_0005963, ciRS-122, and circPTN, and miR-19a-3p which is modulated by circ_0000096 and circ_0063425. Additionally, both miR-223 and miR-24 were found to affect the PI3K/AKT pathway and were regulated by lncGAS5 and lncKCNQ1OT1, respectively. Thus, this work provides a useful pipeline of inter-connected ncRNAs that future research on their impact on DIC can further explore. Full article
(This article belongs to the Special Issue The Role of Non-coding RNAs Involved in Cardiovascular Diseases and Cellular Communication)
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17 pages, 1504 KiB  
Review
Non-Coding RNAs in Cell-to-Cell Communication: Exploiting Physiological Mechanisms as Therapeutic Targets in Cardiovascular Pathologies
by Javier Laura Francés, Elettra Musolino, Roberto Papait and Christina Pagiatakis
Int. J. Mol. Sci. 2023, 24(3), 2205; https://doi.org/10.3390/ijms24032205 - 22 Jan 2023
Cited by 6 | Viewed by 2790
Abstract
Cardiovascular disease, the leading cause of death worldwide, has been characterized at the molecular level by alterations in gene expression that contribute to the etiology of the disease. Such alterations have been shown to play a critical role in the development of atherosclerosis, [...] Read more.
Cardiovascular disease, the leading cause of death worldwide, has been characterized at the molecular level by alterations in gene expression that contribute to the etiology of the disease. Such alterations have been shown to play a critical role in the development of atherosclerosis, cardiac remodeling, and age-related heart failure. Although much is now known about the cellular and molecular mechanisms in this context, the role of epigenetics in the onset of cardiovascular disease remains unclear. Epigenetics, a complex network of mechanisms that regulate gene expression independently of changes to the DNA sequence, has been highly implicated in the loss of homeostasis and the aberrant activation of a myriad of cellular pathways. More specifically, non-coding RNAs have been gaining much attention as epigenetic regulators of various pathologies. In this review, we will provide an overview of the ncRNAs involved in cell-to-cell communication in cardiovascular disease, namely atherosclerosis, cardiac remodeling, and cardiac ageing, and the potential use of epigenetic drugs as novel therapeutic targets. Full article
(This article belongs to the Special Issue The Role of Non-coding RNAs Involved in Cardiovascular Diseases and Cellular Communication)
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