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New Insights of DNA Methylation
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New Insights of DNA Methylation

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (20 March 2024) | Viewed by 3851

Special Issue Editors

Dr. Sara C. Zapico

E-Mail Website
Guest Editor
New Jersey Institute of Technology, Smithsonian National Museum of Natural History, Washington, DC 20013-7012, USA
Interests: molecular biology; genetics; epigenetics; forensic biology
Prof. Dr. Bruce Royston McCord

E-Mail Website
Guest Editor
Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA
Interests: DNA methylation; forensic biology; forensic genetics

Special Issue Information

Dear Colleagues,

DNA methylation is a heritable modification to DNA that does not change its sequence, but strongly affects gene expression. As a result, DNA methylation is implicated in key processes such as embryonic development, genomic imprinting, X chromosome inactivation, and aging. Additionally, it can provide useful biomarkers for cancer, neurodegenerative diseases, and environmental exposure. Based on research on DNA methylation in these areas, other fields, such as forensic sciences, have applied DNA methylation to develop investigative tools such as body fluid identification and age estimation.

This Special Issue will welcome original studies and reviews that focus on DNA methylation, ranging from basic research to its application to biomedical, forensic sciences, and other fields. The aim of this Special Issue is to assemble a collection of studies with the latest advances on DNA methylation, and promote interdisciplinary research among the scientific fields.

Dr. Sara C. Zapico
Prof. Dr. Bruce Royston McCord
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • DNA methylation
  • epigenetics
  • aging
  • cancer
  • neurodegenerative diseases
  • forensic sciences
  • epigenetic clocks

Published Papers (3 papers)

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Research

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11 pages, 825 KiB  
Article
Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis
by Seung Hwan Kim, So Yeon Yu, Jeong Hyeop Choo, Jihyun Kim, Kangmo Ahn and Seung Yong Hwang
Int. J. Mol. Sci. 2024, 25(3), 1579; https://doi.org/10.3390/ijms25031579 - 27 Jan 2024
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Abstract
Bisphenol is a chemical substance widely used in plastic products and food containers. In this study, we observed a relationship between DNA methylation and atopic dermatitis (AD) in the peripheral blood mononuclear cells (PBMCs) of pregnant women exposed to bisphenol A (BPA) and [...] Read more.
Bisphenol is a chemical substance widely used in plastic products and food containers. In this study, we observed a relationship between DNA methylation and atopic dermatitis (AD) in the peripheral blood mononuclear cells (PBMCs) of pregnant women exposed to bisphenol A (BPA) and its alternatives, bisphenol S (BPS) and bisphenol F (BPF). DNA methylation is an epigenetic mechanism that regulates gene expression, which can be altered by environmental factors, and affects the onset and progression of diseases. We found that genes belonging to the JAK-STAT and PI3K-AKT signaling pathways were hypomethylated in the blood of pregnant women exposed to bisphenols. These genes play important roles in skin barrier function and immune responses, and may influence AD. Therefore, we suggest that not only BPA, but also BPS and BPF, which are used as alternatives, can have a negative impact on AD through epigenetic mechanisms. Full article
(This article belongs to the Special Issue New Insights of DNA Methylation)
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19 pages, 4651 KiB  
Article
Evaluation of DNA Methylation Profiles of LINE-1, Alu and Ribosomal DNA Repeats in Human Cell Lines Exposed to Radiofrequency Radiation
by Francesco Ravaioli, Maria Giulia Bacalini, Cristina Giuliani, Camilla Pellegrini, Chiara D’Silva, Sara De Fanti, Chiara Pirazzini, Gianfranco Giorgi and Brunella Del Re
Int. J. Mol. Sci. 2023, 24(11), 9380; https://doi.org/10.3390/ijms24119380 - 27 May 2023
Cited by 2 | Viewed by 2123
Abstract
A large body of evidence indicates that environmental agents can induce alterations in DNA methylation (DNAm) profiles. Radiofrequency electromagnetic fields (RF-EMFs) are radiations emitted by everyday devices, which have been classified as “possibly carcinogenic”; however, their biological effects are unclear. As aberrant DNAm [...] Read more.
A large body of evidence indicates that environmental agents can induce alterations in DNA methylation (DNAm) profiles. Radiofrequency electromagnetic fields (RF-EMFs) are radiations emitted by everyday devices, which have been classified as “possibly carcinogenic”; however, their biological effects are unclear. As aberrant DNAm of genomic repetitive elements (REs) may promote genomic instability, here, we sought to determine whether exposure to RF-EMFs could affect DNAm of different classes of REs, such as long interspersed nuclear elements-1 (LINE-1), Alu short interspersed nuclear elements and ribosomal repeats. To this purpose, we analysed DNAm profiles of cervical cancer and neuroblastoma cell lines (HeLa, BE(2)C and SH-SY5Y) exposed to 900 MHz GSM-modulated RF-EMF through an Illumina-based targeted deep bisulfite sequencing approach. Our findings showed that radiofrequency exposure did not affect the DNAm of Alu elements in any of the cell lines analysed. Conversely, it influenced DNAm of LINE-1 and ribosomal repeats in terms of both average profiles and organisation of methylated and unmethylated CpG sites, in different ways in each of the three cell lines studied. Full article
(This article belongs to the Special Issue New Insights of DNA Methylation)
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Review

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32 pages, 1182 KiB  
Review
Uncovering Forensic Evidence: A Path to Age Estimation through DNA Methylation
by María Josefina Castagnola, Francisco Medina-Paz and Sara C. Zapico
Int. J. Mol. Sci. 2024, 25(9), 4917; https://doi.org/10.3390/ijms25094917 - 30 Apr 2024
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Abstract
Age estimation is a critical aspect of reconstructing a biological profile in forensic sciences. Diverse biochemical processes have been studied in their correlation with age, and the results have driven DNA methylation to the forefront as a promising biomarker. DNA methylation, an epigenetic [...] Read more.
Age estimation is a critical aspect of reconstructing a biological profile in forensic sciences. Diverse biochemical processes have been studied in their correlation with age, and the results have driven DNA methylation to the forefront as a promising biomarker. DNA methylation, an epigenetic modification, has been extensively studied in recent years for developing age estimation models in criminalistics and forensic anthropology. Epigenetic clocks, which analyze DNA sites undergoing hypermethylation or hypomethylation as individuals age, have paved the way for improved prediction models. A wide range of biomarkers and methods for DNA methylation analysis have been proposed, achieving different accuracies across samples and cell types. This review extensively explores literature from the past 5 years, showing scientific efforts toward the ultimate goal: applying age prediction models to assist in human identification. Full article
(This article belongs to the Special Issue New Insights of DNA Methylation)
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