Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.8
5.6
Journals
IJMS
Special Issues
Cellular and Molecular Mechanisms Involved in Prostate Cancer Cell Migration...
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Cellular and Molecular Mechanisms Involved in Prostate Cancer Cell Migration and Invasion

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 4456

Special Issue Editors

Prof. Dr. Chunhong Yan

E-Mail Website
Guest Editor
Georgia Cancer Center, Augusta University, Augusta, GA, USA
Interests: prostate cancer; androgen receptor; cell signaling; cellular stress response; drug development; transcriptional regulation
Prof. Dr. Shafiq Khan

E-Mail
Guest Editor
Department of Biological Sciences, Clark Atlanta University, Atlanta, GA 30314, USA
Interests: prostate cancer; cell proliferation; cell migration; metastasis; cell signaling; growth factors; androgens

Special Issue Information

Dear Colleagues,

The process of metastasis starts with the dissemination of cancer cells from the primary tumor and ends with the formation of detectable macrometastases at distant sites. Metastasis of epithelial cancer cells is a multi-stage process involving epithelial to mesenchymal transition (EMT), degradation of extracellular matrix, cell migration and invasion of the neighboring tissues, intravasation into blood or lymph vessels, transportation and extravasation, mesenchymal to epithelial transition (MET), and growth of metastatic tumors at distant locations.

This issue will accept research papers and review articles focusing on the molecular mechanisms involved in the regulation of EMT, breakdown of extracellular matrix, cell migration, cell invasion and metastasis in prostate cancer cells.

Prof. Dr. Chunhong Yan
Prof. Dr. Shafiq Khan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prostate cancer cells
  • EMT
  • extracellular matrix degradation
  • cell migration and invasion
  • metastasis

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

32 pages, 5491 KiB  
Article
Age- and Stage-Dependent Prostate Cancer Aggressiveness Associated with Differential Notch Signaling
by Magdalena Julita Orzechowska, Dorota Anusewicz and Andrzej K. Bednarek
Int. J. Mol. Sci. 2023, 24(1), 164; https://doi.org/10.3390/ijms24010164 - 22 Dec 2022
Cited by 2 | Viewed by 1719
Abstract
Prostate cancer (PC) remains a worldwide challenge, as does the question of how to distinguish its indolent from its aggressive form to reconcile proper management of the disease with age-related life expectations. This study aimed to differentiate the Notch-driven course of PC regarding [...] Read more.
Prostate cancer (PC) remains a worldwide challenge, as does the question of how to distinguish its indolent from its aggressive form to reconcile proper management of the disease with age-related life expectations. This study aimed to differentiate the Notch-driven course of PC regarding patients’ ages and stage of their disease. We analyzed 397 PC samples split into age subgroups of ≦55, 60–70, and >70 years old, as well as early vs. late stage. The clinical association of Notch signaling was evaluated by DFS and UpSet analyses. The clustering of downstream effectors was performed with ExpressCluster. Finally, for the most relevant findings, functional networks were constructed with MCODE and stringApp. The results have been validated with an independent cohort. We identified specific patterns of Notch expression associated with unfavorable outcomes, which were reflected by entering into a hybrid epithelial/mesenchymal state and thus reaching tumor plasticity with its all consequences. We characterized the molecular determinants of the age-related clinical behavior of prostate tumors that stem from different invasive properties depending on the route of the EMT program. Of the utmost relevance is the discovery of age- and stage-specific combinations of the Notch molecules predicting unfavorable outcomes and constituting a new prognostic and therapeutic approach for PCs. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms Involved in Prostate Cancer Cell Migration and Invasion)
►▼ Show Figures

Figure 1

22 pages, 9173 KiB  
Article
A Novel L-Phenylalanine Dipeptide Inhibits the Growth and Metastasis of Prostate Cancer Cells via Targeting DUSP1 and TNFSF9
by Lanlan Li, Mingfei Yang, Jia Yu, Sha Cheng, Mashaal Ahmad, Caihong Wu, Xinwei Wan, Bixue Xu, Yaacov Ben-David and Heng Luo
Int. J. Mol. Sci. 2022, 23(18), 10916; https://doi.org/10.3390/ijms231810916 - 18 Sep 2022
Cited by 4 | Viewed by 2290
Abstract
Prostate cancer (PCa) is a common malignant cancer of the urinary system. Drug therapy, chemotherapy, and radical prostatectomy are the primary treatment methods, but drug resistance and postoperative recurrence often occur. Therefore, seeking novel anti-tumor compounds with high efficiency and low toxicity from [...] Read more.
Prostate cancer (PCa) is a common malignant cancer of the urinary system. Drug therapy, chemotherapy, and radical prostatectomy are the primary treatment methods, but drug resistance and postoperative recurrence often occur. Therefore, seeking novel anti-tumor compounds with high efficiency and low toxicity from natural products can produce a new tumor treatment method. Matijin-Su [N-(N-benzoyl-L-phenylalanyl)-O-acetyl-L-phenylalanol, MTS] is a phenylalanine dipeptide monomer compound that is isolated from the Chinese ethnic medicine Matijin (Dichondra repens Forst.). Its derivatives exhibit various pharmacological activities, especially anti-tumor. Among them, the novel MTS derivative HXL131 has a significant inhibitory effect against prostate tumor growth and metastasis. This study is designed to investigate the effects of HXL131 on the growth and metastasis of human PCa cell lines PC3 and its molecular mechanism through in vitro experiments combined with proteomics, molecular docking, and gene silencing. The in vitro results showed that HXL131 concentration dependently inhibited PC3 cell proliferation, induced apoptosis, arrested cell cycle at the G2/M phase, and inhibited cell migration capacity. A proteomic analysis and a Western blot showed that HXL131 up-regulated the expression of proliferation, apoptosis, cell cycle, and migration-related proteins CYR61, TIMP1, SOD2, IL6, SERPINE2, DUSP1, TNFSF9, OSMR, TNFRSF10D, and TNFRSF12A. Molecular docking, a cellular thermal shift assay (CETSA), and gene silencing showed that HXL131 had a strong binding affinity with DUSP1 and TNFSF9, which are important target genes for inhibiting the growth and metastasis of PC3 cells. This study demonstrates that HXL131 exhibited excellent anti-prostate cancer activity and inhibited the growth and metastasis of prostate cancer cells by regulating the expression of DUSP1 and TNFSF9. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms Involved in Prostate Cancer Cell Migration and Invasion)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop