Recent Advances in Antidepressants and Mood-Stabilizing Drugs
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 15505
Special Issue Editor
Interests: cell culture; molecular biology; noncoding RNA; genetics; extracellular vesicles; allergy; pulmonology; psychiatry; adipokines; stress response
Special Issue Information
Dear Colleagues,
The Special Issue follows the publication of the first edition on "Molecular Mechanisms of Mood Stabilizers”, which presented seven high-quality papers. I would like to welcome you to this new Special Issue, “Recent Advances in Antidepressants and Mood-Stabilizing Drugs”, of the International Journal of Molecular Sciences, which focuses on the mechanisms of actions of antidepressants and mood-stabilizing drugs.
Mood disorders are common chronic psychiatric conditions with a high socioeconomic burden, affecting mainly young adults and often present in recurrent episodes of depression or mania. The term ‘mood stabilizers’ encompasses a heterogeneous class of drugs, including anticonvulsants, antipsychotics, and lithium, that are used to treat these psychiatric conditions. However, their efficacy differs significantly depending on age at onset, disease duration, gender, and comorbidities. The available treatment is effective in about 60% of chronically treated patients, while the remaining 40% require a switch to another drug or a combination of several normotymic agents. Despite several decades of clinical use and numerous molecular studies conducted to elucidate the molecular mechanism of mood stabilizers, their exact mechanisms have yet to be fully identified. The discovery of molecular pathways influenced by mood stabilizers could improve treatment response prediction, as well as the identification of novel therapeutic targets for mood disorders.
This Special Issue welcomes original papers or review articles on molecular aspects of mood stabilizer action, with a particular focus on delineating the changes in gene expression regulation (including epigenome, noncoding RNAs, transcriptome, and proteome), using in vitro studies, animal models, and clinical studies. Works investigating the role of comorbidities on molecular action of mood stabilizers are also encouraged. Pure clinical studies will not be considered.
Prof. Dr. Aleksandra Szczepankiewicz
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mood stabilizers
- antidepressants
- molecular action
- affective disorders
- comorbid diseases
- epigenetics
- noncoding RNA
- transcriptome
- proteome
- animal models
- in vitro models
- clinical studies
