Molecular Research on Eryptosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 2747
Special Issue Editors
Interests: biochemistry and methodologies; Sicilian foods; bioactive compounds; phytochemicals; bioactivity; cell cultures; chemoprevention; oxidative stress; apoptosis; eryptosis
Special Issues, Collections and Topics in MDPI journals
Interests: nutraceuticals; bioactivity of natural products; betalain pigments; biochemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Eryptosis is defined as programmed cell death of red blood cells (RBCs). Similarly to apoptosis in nucleated cells, eryptosis is characterized by cell shrinkage, membrane blebbing and loss of membrane phospholipid asymmetry with phosphatidylserine exposure at the erythrocyte surface.
Eryptosis is a physiological process that allows senescent or damaged RBCs to be recognized and removed by macrophages preventing hemolysis and subsequent release of hemoglobin and pro-inflammatory cytosolic material into the bloodstream. It is triggered by several stressors such as hyperosmolarity, energy depletion, hyperthermia, oxidative stress and a wide variety of xenobiotics and endogenous compounds.
Excessive eryptosis is associated with several clinical conditions including atherosclerosis, atherothrombosis, iron deficiency, thalassemia, hemolytic uremic syndrome, myelodysplastic syndrome, cardiac and renal failure, Wilson’s disease, obesity, diabetes, chronic inflammatory diseases, malignancies, mycoplasma infection and malaria. In fact, since eryptotic RBCs can adhere to endothelial cells and thrombocytes compromising vascular microcirculation, it contributes to the complications associated with cardiometabolic and inflammatory diseases.
Investigating the effects of endogenous, natural or synthetic molecules in reducing erythrocyte death could provide novel insights into their possible use as protective agents in a variety of systemic diseases.
This special issue aims to collect original research articles and reviews that describe the molecular pathways of programmed erythrocyte death in the context of disease-related conditions.
Dr. Alessandro Attanzio
Prof. Dr. Luisa Tesoriere
Guest Editors
Manuscript Submission Information
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Keywords
- Eryptosis
- Red blood cell
- Senescence
- Metabolic syndrome
- Lifestyle
- Antioxidants
