The Microbiota-Gut-Brain Axis in Relation to Non-communicable Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 5788
Special Issue Editors
Interests: food science and technology; phytochemistry; bioactive compounds; health-promoters, functional ingredients; natural foods; healthy foods; energy metabolism (obesity and diabetes); human nutrition; wellbeing
Special Issues, Collections and Topics in MDPI journals
Interests: metabolism; obesity; diabetes; non-alcoholic fatty liver disease; nutrition; microbiota; metabolomics; epigenetics
Special Issues, Collections and Topics in MDPI journals
2. Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain
Interests: immunology; inflammation; macrophages; cell biology; in vitro models for drug development; cirrhosis; endometriosis; diabetes; insulin resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent decades, microbiome research has evolved rapidly, and, nowadays, it not only represents a hot topic in basic, preclinical, and clinical research, but also for food science and nutrition, as well as for the pharmaceutical research, with implications for all the related industry of these areas.
The discovery of the gut–brain axis as the crucial connection between gut microbiota and the nervous system, and the growing body of evidence on the connections between gut microbiota and nervous system physiology and pathology is increasing awareness around bidirectional communication along the microbiota–gut–brain axis (MGBA) mediated by biologically active molecules and metabolites.
The appearance of intestinal dysbiosis leads to changes in the bidirectional relationship of the MGBA. It can also impact the brain, as well as the aging and the deterioration of the nervous system, driving towards pathological conditions such as Alzheimer’s disease and stroke.
Comparatively, the MGBA can be influenced by nutrients and bioactive molecules, inducing the secretion of specific hormones, which can then lead to changes in the energy metabolism and expenditure. The design of drugs, functional foods, and ingredients based on bioactive molecules exploiting the involved mechanisms may offer interesting alternatives for the treatment of non-communicable and high-prevalence diseases, such as obesity, type 2 diabetes, and other metabolic syndromes and co-morbidities.
This Special Issue aims to gain novel and applicable knowledge on all these aspects, with contributions from the different areas involved.
Dr. Diego A. Moreno
Dr. Bruno Ramos-Molina
Dr. Antonio J. Ruiz-Alcaraz
Guest Editors
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Keywords
- gut–brain axis
- gut microbiota
- behavior
- bioactive molecules
- cognitive health
- diabetes
- in vitro models
- in vivo models
- hormones
- intestine
- obesity
- probiotics
- prebiotics
- synbiotics